Emulate, Inc.

Using Organ-on-a-Chip Technology to Unlock Patient-Derived Precision Medicine Discover how Organ-Chip models using patient-derived samples are advancing personalized medicine — and read three case-studies showing real-world impact in bone-marrow toxicity, neurodegeneration (ALS...

🧪 What if we could predict a patient’s treatment response before they receive it? #OrganonChip technology offers a home away from home for patient-derived samples—revealing how cells truly respond to therapy.

Full story 👉 emulatebio.com/using-organ-...

#PersonalizedMedicine #PrecisionMedicine

A New Paradigm for Personalized Cancer Medicine: Predicting Patient-Specific Therapeutic Responses with Organ-on-a-Chip Technology Personalized medicine has long held the promise of tailoring treatments to the biology of each individual patient. Until now, however, the field has lacked a truly predictive human model. In […]

🔗 Register: emulatebio.com/event/a-new-...

#OrganonChip #CancerResearch #PrecisionOncology

🧪A breakthrough for personalized medicine:
Patient-derived Organ-Chips can now predict individual responses to cancer therapy — outperforming organoids.

Join Dr. Lorenzo Ferri & Dr. Donald Ingber on October 30th for a live webinar exploring this new paradigm in precision oncology. 👇

Regulators are calling for human-relevant data. 📊

Our CEO Jim Corbett shares how the new AVA™ Emulation System delivers scale + reproducibility for #OrganonChip studies to support FDA submissions and usher in a new era of drug discovery.

👉 Read more: emulatebio.com/insights-int...

Nominations for the 2026 #LushPrize open Sept 1!

In 2024, we won for our landmark Liver-Chip study, proving it can outperform animal tests for predicting DILI & advancing human-relevant science.

Who will lead the next leap forward? 🔗 lushprize.org

@lushprize.bsky.social

#OrganOnChip

A Regulatory Turning Point: A Recent Timeline of U.S. Actions to Reduce and Replace Animal Models in Preclinical Research Discover how FDA, NIH and Congress are fast tracking alternatives to animal testing—and how Organ on a Chip technology is reshaping drug development.

🧪In our latest #blog, we're talking about the key US policy moves that are positioning #OrganonChip and other New Approach Methodologies (NAMs) to become the default alternatives to animal testing in drug development.

emulatebio.com/alternatives...

#drugdiscovery #sciencepolicy #NAMs

Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip - Scientific Reports Scientific Reports - Hepatotoxicity evaluation of cannabidiol, cannabinol, cannabichromene and cannabigerol using a human quad culture liver chip

This study revealed that cannabinoids have distinct, dose-dependent hepatotoxicity profiles, highlighting the importance of human-relevant models for cannabinoid safety evaluation.

Read the full paper here: www.nature.com/articles/s41...

Takeaway #1: The Liver-Chip S1 demonstrated differential toxicity profiles of four cannabinoids that traditional animal models could not clearly distinguish.

Takeaway #2: The Liver-Chip S1 identified parenchymal cell-specific mechanisms of cannabinoid toxicity--effects that would have been missed by standard monoculture assays.

Takeaway #3: The Liver-Chip S1 revealed early inflammatory and functional markers of cannabinoid toxicity, offering insight into potential mechanisms and early warning signs.

Takeaway #4: The Liver-Chip S1 modeled dose- and compound-specific hepatotoxicity using clinically relevant exposures of cannabinoids.

🧪 We’re excited to share the results of a recent collaboration with @herbalifeglobal.bsky.social, now published in Science Reports!

Using Emulate’s #organonchip Quad-Culture Liver-Chip S1, this study explored the #hepatotoxicity potential of four common #cannabinoids — CBD, CBG, CBN, and CBC.

Some examples of the types of lists you can generate include:

🔬 Cancer models of the digestive system
🦠 Infectious disease applications in the lung
☣️ Toxicology studies of the liver
🧫 Microbiome research of the reproductive system

Download the digest today to start exploring!

This digest is also a handy tool for easily compiling a complete list of publications tailored to your organ model and application of interest. Simply set your filter criteria, and the digest will generate a curated list of reference publications for you!

Emulate Community Publications Digest: Summer 2025 Issue With over 120 publications across 30+ organ models, Emulate Organ-Chips are empowering researchers to make game-changing scientific breakthroughs! Download this digest to easily explore all publicatio...

🧪The newest edition of the Emulate Community Publications Digest is live! We're spotlighting all the recent research from our user community, from patient-matched cancer models to spinal cord chips for modeling sporadic ALS. Download your copy today!
emulatebio.com/resources/em...
#organonchip

New Approach Methodologies (NAMs): The Future of Toxicology and Safety Testing This blog explores the landscape of NAMs, explains how they can be used synergistically, and highlights the key factors driving their recent momentum.

New blog post alert! If you've heard about "NAMs" but aren't sure what the term means, we've got just the blog for you! Check out our latest post to learn what #NAMs are and how they're driving a new era of human-relevant drug discovery and development! emulatebio.com/new-approach...

Built-in incubation, automated imaging, and AI-ready data generation deliver in vivo fidelity at scale.

Meet AVA: emulatebio.com/ava

Emulate Launches AVA™ Emulation System to Accelerate Drug Development with First-of-its-Kind High-Throughput Organ-Chip Platform Built-in incubation, automated imaging, and AI-ready data generation deliver in vivo fidelity at scale Boston, MA – Emulate, Inc., the world leader in Organ-on-a-Chip technology, today announced the c...

ICYMI: This month, we heralded in the future of human-centric drug development with the launch of the AVA Emulation System, a first-of-its-kind high-throughput Organ-Chip platform. #organonchip
emulatebio.com/press/emulat...

Using Organ-on-a-Chip and iPSC Technology to Model Neurological Diseases Join us on Tuesday, May 27th at 11:30AM EDT (8:30AM PDT / 4:30PM  BST / 5:30PM CEST), where Dr. Clive Svendsen from Cedars-Sinai will discuss how Organ-on-a-Chip technology is enabling […]

🧠 We're only 5 days away from our next webinar! Join us on May 27 as Dr. Clive Svendsen from Cedars-Sinai presents his work using Organ-Chips and iPSCs to model multiple neurological diseases, including ALS, Parkinson’s disease, and FTD. Register now! emulatebio.com/event/using-...

Picture of Emulate's CEO Jim Corbett featuring a quote from the press release

🧪 A new era of drug development: Read our latest press release to learn why we believe the FDA's groundbreaking plan to reduce #animaltesting is a pivotal step forward for patients, researchers, and the entire healthcare ecosystem, and how #organonchip can help.

emulatebio.com/press/emulat...

📢NEW PRODUCT ANNOUNCEMENT 📢
You asked, we listened! Introducing 🥔🫁Organ-Chips 🧠🥔, the perfect lab snack to complement your #OrganOnChip experiments. Take a break from seeding Liver-Chips and feed on some Liver-Chips! Sign up for access today!
marketing.emulatebio.com/l/1080863/20...

Liver Toxicology White Paper: Setting a New Standard in Drug Safety Testing Discover how the Liver-Chip S1 is transforming drug development and toxicology prediction. This white paper highlights key findings from our 2022 Communications Medicine study, where the Liver-Chip ac...

So as we all raise a glass (or two!), let’s give a nod to the amazing work our livers do—and the innovative research fueling the next wave of healthcare breakthroughs. Check out our latest White Paper on liver #toxicology to learn more. Sláinte!

emulatebio.com/resources/li...

Cover photo of Emulate's liver toxicology white paper on a background featuring a fluorescence image of hepatocytes on an Organ-Chip.

Happy #StPatricksDay! While many will be “exercising” their livers today, here at Emulate, we’re celebrating by putting our Liver-Chip to work in the lab! Our #organonchip technology helps researchers better understand liver function and disease, paving the way for more effective treatments.

They also confirmed that MNP uptake involves both passive diffusion and active endocytosis pathways—suggesting that even “low-toxicity” levels of plastics can still get absorbed and potentially affect gut biology.

Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn’s disease human duodenum-chip models Micro and nanoplastics (MNPs) are widespread environmental and food web contaminants that are absorbed by the intestine and distributed systemically, …

🧪New study using a human Intestine-Chip found that #microplastics / #nanoplastics caused minimal toxicity in both healthy and #Crohn’s small intestinal tissue, but did impact genes linked to immune defense. #OrganOnChip
www.sciencedirect.com/science/arti...

Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology - Communications Medicine Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry...

Hi Jules, we'd love to be added! We are an Organ-Chip technology provider. Website: emulatebio.com. Here's a link to our seminal paper on how our Liver-Chip model outperforms animals and spheroids for DILI prediction: www.nature.com/articles/s43...

Frontiers | Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

🧪 Predicting which drugs will be toxic to the human liver remains a challenge, in part because 2D cell and animal models are not sensitive enough. This article discusses how complex in vitro models such as #Organ-Chips are changing the safety testing paradigm: www.frontiersin.org/journals/dru...

Celebrate the day in style by reading the publication here: pubs.rsc.org/en/content/a...

Happy #ValentinesDay and may your monocultures find a friend today!

Endothelial cells, cardiomyocytes in sync,
Predicting drug harm before hearts even blink.
Multi-lineage models to catch toxicity’s call,
Keeping hearts safe and healthy for all!

Roses are red, violets are blue,
Old heart models lack the punch they once knew.
But on an Organ-Chip— #hiPSC so refined—
Flow and stretch bring true maturity in kind.

In the spirit of 🩷 Valentine's Day 🩷 , we've written a little ode to #OrganChips, inspired by the recent Heart-Chip publication from Cedars-Sinai!

*Ahem*

This webinar will explore how the IBD Organ-Chips helped reveal critical insights into the pathogenesis of IBD, including the pivotal role of intestinal stroma and mechanical deformations in driving sex-specific disease progression!

Human Organ-Chips Reveal New Inflammatory Bowel Disease Drivers Join us on Monday, February 24th at 11AM EST (8AM PST / 4PM  GMT / 5PM CET), where Dr. Alican Ozkan from the Wyss Institute will discuss how he and […]

Join us for a live webinar on Monday, February 24th at 11AM EST to hear Dr. Alican Ozkan from the Wyss Institute share groundbreaking insights into modeling Inflammatory Bowel Disease (IBD) with Organ-on-a-Chip technology. Learn more: emulatebio.com/event/human-...

Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis - npj Women's Health npj Women's Health - Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis

An integrated Cervix + Vagina-Chip study shows cervicovaginal mucus plays a protective role against bacterial vaginosis (BV) by reducing inflammation and epithelial damage from dysbiotic microbes, opening new avenues of #research for women’s #reproductivehealth. 🧪

www.nature.com/articles/s44...