David B. Sauer

Colin Kleanthous' fundraiser for Motor Neurone Disease Association Help Colin Kleanthous raise money to support Motor Neurone Disease Association

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)

Faculty and academic positions – University of Copenhagen

Looking for a Post doc position in Structural Biology? We are hiring!
See post here:
jobbank.dk/job/2850337/...

The task is to continue our endeavor in solving cryo-EM structures of the human dopamine transporter. See: doi.org/10.1038/s415...
Thanks to the Novo Nordisk Foundation for funding.

Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5 Functional and mechanistic analysis of all single–amino acid variants in the human citrate transporter SLC13A5.

Wow! Deep Mutational Scan of NaCT!!

www.science.org/doi/10.1126/...

Valuable to biochem. understand NaCT folding & function, and clinical VUS in SLC13A5-Epilepsy

Beautiful study and Herculean effort by Wen-An Wang and REsolution colleagues in @supertifurgalab.bsky.social at @cemm.oeaw.ac.at

Closing soon!

Please apply if you are interested in targeting membrane proteins with new therapeutics!

Unacceptable! 😡😡
Review deadline of 2 weeks, then cancel at 4 days as "time restrictions are too tight"

"Paper [achieved] the required review" == editor knew this was waste of time

I will always support colleagues by reviewing papers, but my view of your journal has changed.

Hello Carolina,
Happy to chat! Just email me and we can arrange a time!

Best wishes,
David

Ugh. Account on Twitter is hacked.

Still annoying, even if I'm not active there much these days.

Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving the landscape of Gi activation and how its modulated by different ligands!
www.biorxiv.org/content/10.1...

Photo of a Sauer Membrane Protein group party, why space for a new hire

Join our group in the Centre for Medicines Discovery at Oxford Univ. @cmd.ox.ac.uk @ox.ac.uk !!!!

Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.

Please RT!

my.corehr.com/pls/uoxrecru...

Ain't this place a geographical oddity, 2 weeks from everywhere! (GIF from the movie O Brother, Where Art Thou?)

University bureaucracy (probably universal)

The 3rd NYC Integrative Structural Biology Symposium (#NYCISB25) will be Oct 9-10, 2025.

Register today:
nyc-isb25.eventbrite.com

This event will be focused on integrative structural biological techniques and limited to 100 attendees.

Cover of the May 2025 issue of Cell Reports

@annaliiiiiiii.bsky.social got the cover of @cp-cellreports.bsky.social for her human muscle-type nAChR structure

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation.

Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation.

cryotud.github.io/locscale/

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

CCP-EM Spring Symposium 2025 - YouTube The 11th annual CCP-EM Spring Symposium was held from the 23-25th April 2025 at the East Midlands Conference Centre, University of Nottingham as a hybrid in-...

2025 Spring Symposium lectures are now up on our YouTube channel: www.youtube.com/playlist?lis...

Today is SLC13A5 Epilepsy International Awareness Day, I'm reminded in an email this morning from Kim Nye, founder of TESS Research Foundation.
Read more here: www.tessresearch.org/awareness/ and …

Cover photo of Nature Structural and Molecular Biology with cinnamon rolls

Hungry thanks to cinnamon rolls on the March issue of Nature Structural & Molecular Biology...

Think I'll have a snack while reading about NaDC3 (@danengw.bsky.social), yeast CerS complex (@arnemoeller.bsky.social & @flofroehlich.bsky.social), and human CerS6 by our own @tomaspascoa.bsky.social

CCeMMP Seminar alert⏰ We welcome Professor Juan Du, Department of Molecular Biosciences, Northwestern University, Illinois, USA!
“The importance of Physiological Temperature in Biomedical & Biophysical Research”
More details and register:
ccemmp.org/events/ccemm...

And thank you @lane-b.bsky.social for hosting!

Fantastic visit to @astonaime.bsky.social today. Amazing work is happening here for membrane protein study and the development of purification technologies!

Thank you @naomilpollock.bsky.social for the invite, and everyone at AIME for the fascinating conversations!!

Trying to do a bit of good in a recently stressful and chaotic world…

Dear al,
check out our latest paper with @uhammes.bsky.social .
A great collaborative effort by Lukas and Lam!!

A pleasure presenting our work at @cmd.ox.ac.uk using CryoEM to study Solute Carriers!

Thank you @drlornamalone.bsky.social and @walshdls.bsky.social for the invitation, and the fascinating conversations with @ccpem.bsky.social colleagues

Keynote at BCI user meeting (eBIC and B24) at Diamond Light Source

First keynote of the day #bcium2025 from David Sauer @davidbsauer.bsky.social @diamondlightsource.bsky.social @ccpem.bsky.social @instruct-eric.bsky.social

View from the stage #bci-ccpem2025 @ccpem.bsky.social just about to start!

Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states Mutations in the muscle-type AChR are associated with a rare neuromuscular disorder known as congenital myasthenic syndrome (CMS). Li et al. report the cryo-EM structures of human adult muscle-type AC...

And it's published in Cell Reports!

www.cell.com/cell-reports...

Mandatory online security training... with the video quality of a 1990s game cutscene.

Nostalgia has me wanting a pack of Redvines and a dark room for hours of GDI vs NOD battles!

Collaborating to study the transport and inhibition of the immunoregulatory sphingosine-1-phosphate exporter SPNS2 Probing the sphingosine-1-phosphate exporter SPNS2 through an international collaboration of academia and industry, with results reporting a novel high-throughput screening assay, small-molecule targe...

Fun little write-up of the SPNS2 collaboration :)

Also, my first exercise with Blender and Molecular Nodes. Wow, does it make pretty pictures! Thanks for the YouTube tutorials @bradyajohnston.bsky.social.

go.nature.com/41XuE25

Text overlaying a grid of cryo-EM images of heterogeneous samples. Text: Cryo-EM Summer Workshop, June 1-5, 2025.

*Deadline extended*
Applications for this year's #CryoEM Data Processing Workshop are due March 27!
Don't miss this chance to learn about various approaches to deal with conformational/compositional heterogeneity.
myumi.ch/lsi-cryo-2025
@jbquerido.bsky.social
@shyamalm.bsky.social

Congrats! Columbia's science will be all the better for your leadership!