Charlotte Capitanchik

an internet explorer window against the windows xp background with a geocities.com address in the bar "/Kingofkings". The page displayed is a broken image on a black background, and the sentence: "My name is Ozymandias, King of Kings; Look upon my Works, ye Mighty, and despair!"

If I had to do a second PhD it would for sure be this one! So exciting!

So cool they discovered the cause of autism on basically day they guessed they would. I’m also glad they are withholding this information for a few days to prep for a WrestleMania-style announcement. This is how science works.

Like & share our new promo vid for Flow.bio! Capturing just a little bit of that bioinformatics trauma 🫠 www.youtube.com/watch?v=MR-R...

Tylenol and Autism Earlier this year, HHS secretary RFK Jr. predicted that, "By September, we will know what has caused the autism epidemic and we'll be able to eliminate those exposures." Scientists have been researc

Acetaminophen/paracetamol use in pregnancy doesn't cause autism, no matter what RFK says this week. This is not an unsettled question. Evidence summarized here: sciencebasedmedicine.org/tylenol-and-...

Only single cell sequencing of the all these post docs will reveal why

Congratulations to @bencekover.bsky.social for winning the best talk prize for schooling us all on best practises in mass scRNA-Seq data integration #Londonomics2025

Can’t thank our career mentors enough for the great discussions in our mentorship session @margaridamcm.bsky.social @kristinaulicna.bsky.social @gavinpaulkelly.bsky.social and Mara Tatari 💪#Londonomics2025

In the afternoon we had an excellent talk about AlphaMissense and AlphaGenome from @avsecz.bsky.social who generously allowed us to heckle him during the talk, answering all our questions!

In the morning we enjoyed 11 short talks from computational biology ECRs - I especially liked @saniyakhullar.bsky.social’s talk on incorporating prior PPI knowledge into gene regulatory network inference #londonomics2025

Had such a great time at #Londonomics2025 today - excellent talks and discussions - thank you to everyone who came along and shared their ideas with us.

Sounds like a wonderful position

RUN, DON'T WALK to sign up for the londonomics symposium! we gotta order the sandwiches soon, so grab your ticket while you can! come hear about AlphaGenome & other great omics work, get career advice and hang out with us, it'll be so great i promise register.oxfordabstracts.com/event/75604?...

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

Did GPT-5 make this graph?

Registration here ➡️ register.oxfordabstracts.com/event/75604?...

Excited for this! Please do come and present your work :D

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

This work is the result of a fantastic collaboration between my lab at the University of Michigan, Mitchell Guttman lab at Caltech, and Marko Jovanovic lab at Columbia University.
www.cell.com/cell/fulltex...
#Ribosomes #Science #CryoEM #RNA

😂

New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples.

Read more: genome.ucsc.edu/gold...

Generative AI’s crippling and widespread failure to induce robust models of the world LLM failures to reason, as documented in Apple’s Illusion of Thinking paper, are really only part of a much deeper problem

"It is not just that LLM’s fail to induce proper world models of chess. It’s that they never induce proper worlds of anything. Everything that they do is through mimicry, rather than abstracted cognition across proper world models."

garymarcus.substack.com/p/generative...

Totally agree!! "How to make the next PDB" This is exactly what we've attempted to do for functional genomics with flow.bio www.biorxiv.org/content/10.1...

@simranolak.bsky.social 🙌

The molecular landscape of cellular metal ion biology Aulakh et al. systematically investigated how metal ion availability impacts yeast biochemistry. Their metallomic, proteomic, and genetic screens reveal the widespread metal concentration dependence o...

incredible work by an incredible scientist (and friend)! very beautiful figures too www.cell.com/cell-systems...

"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants.

Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."

can't wait to try this out :D

Saturation genome editing of RNU4-2 reveals distinct dominant and recessive neurodevelopmental disorders Recently, de novo variants in an 18 nucleotide region in the centre of RNU4-2 were shown to cause ReNU syndrome, a syndromic neurodevelopmental disorder (NDD) that is predicted to affect tens of thous...

🚨I could not be more excited to share our new preprint on saturation genome editing of the small nuclear RNA (snRNA) RNU4-2:
www.medrxiv.org/content/10.1...

A super fun collaboration with incredible duo @gregfindlay.bsky.social @joachimdejonghe.bsky.social from @crick.ac.uk
🧬🖥️🩺

🧵1/12

We're so pleased that groups have been ordering our TDP-REG vectors from Addgene! Please be aware that splicing minigenes cannot easily be used with lentiviruses, because the lentiviral RNA can get spliced before viral packaging! Better to use piggybac or similar, AAV, or just transient transfection

We are so close to AGI

DART-Eval: A Comprehensive DNA Language Model Evaluation Benchmark on Regulatory DNA Recent advances in self-supervised models for natural language, vision, and protein sequences have inspired the development of large genomic DNA language models (DNALMs). These models aim to learn gen...

(1/10) Excited to announce our latest work! @arpita-s.bsky.social, @amanpatel100.bsky.social , and I will be presenting DART-Eval, a rigorous suite of evals for DNA Language Models on transcriptional regulatory DNA at #NeurIPS2024. Check it out! arxiv.org/abs/2412.05430