David W. Sanders!

This is a positive development, given the possibility of a pocket rescission as early as August 15.

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social.
How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.

Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...

The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...

Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins The kinase RIPK3 suppresses pathologic neuroinflammation in mouse models of flavivirus infection.

Excited to announce that our collaboration with @briandaniels.bsky.social has been published today! So happy for everyone involved, but especially me and Marissa 😆. Check it out if you're interested in #neuroinflammation and the #BBB www.science.org/doi/10.1126/...

oligomeric amyloid beta, you say? please tell me more! 🍿

Eighteen million years of diverse enamel proteomes from the East African Rift - Nature The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteom...

You may die, but sialophosphoproteins will live forever. www.nature.com/articles/s41...

so does this mean that I dont need to bother with IACUC approval anymore? sweet.

I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.

Hi! And...no.

Love that “graphical abstract”. Look forward to reading, as this is a critical topic that remains confusing to many that are condensate-curious. Good luck with peer review!

If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...

will allen is a fantastic ESI: glad to see this out!

This is an awesome story. Congrats Jun and Daniel!

Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy Enforced mitophagy enables efficient mitochondrial depletion in pluripotent stem cells and embryos, allowing the creation of human-ape fusion PSCs with defined mitochondrial origins, which reveal crit...

Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the @peterlylab.bsky.social What began as pure curiosity led to a tool for modulating mitochondrial abundance in vitro and in vivo. A new direction for the Wu lab begins! www.cell.com/cell/fulltex...

So a cross-link / dimerization domain is a killswitch now?

You can do this in the cover letter. But from my conversations with others (and my own experience), an algorithm decides (eg wrote in cover letter “please don’t assign me to x” and my r01 was sent to x). If you want to game the system, use this: public.csr.nih.gov/ForApplicant...

I always submit my best papers to the Journal of Crustacean Biology. they are usually desk-rejected then re-routed to Journal of Cell Biology. I never complain. JCB is JCB.

It’s a tough time for science so it feels odd to mention positives, but the Wert lab has had some amazing positive funding news come through and we are seeking talented and motivated postdocs! Please share! labs.utsouthwestern.edu/wert-lab

Nonrandom interchromatin trafficking through dynamic multiphase speckle connections Nuclear speckles (NS) enhance the expression of NS-associated genes, possibly by elevating local levels of factors involved in multiple steps of gene expression. While dozens of large NS are distribut...

www.biorxiv.org/content/10.1... from Andrew Belmont lab

This has a number of interesting observations regarding oncogenic fusion proteins in nuclear envelope and nuclear body organization. While I’ve largely moved on from phase separation, I like this. Congrats, Josh!

This work is very cool—amazing college thesis work!

So far, no organelle we've seen comes close to the replication organelles from langatvirus infections: www.biorxiv.org/content/10.1...

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. www.cell.com/cell/fulltex....

Really cool work Ben. Great to see this out!

so sick of my favorite journal, CHEST, rejecting my PERFECT lumbar puncture manuscripts! about time Johnny law cracks down on their ABSOLUTELY UNFAIR "peer" review!

Could blocking ‘jumping genes’ help fight disease and aging? The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

www.science.org/content/arti...

Yay, Regina!

Ha!

Congrats on being invited to prom!