John Newman, MD, PhD

Today is a special day! It's our second BARI symposium at the de Young Museum in the beautiful Golden Gate Park.

Outstanding work, Emily! I'm so excited to see this cool story out! What a great example of "that's odd" being the most important words in science.

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...

Come visit the Buck booth at North Bay Science Discovery Day at the Sonoma County Fairgrounds today! We’re in The Hall of Flowers. Booth 24. We’ve got some really cool experiments to check out! @northbayscience

"I'm not here because I want to live forever... but I hope you can help me live better." - Goals of care elicited in geriatric medicine clinic from a real 87 year-old women, and one of the best mission statements I've heard for #geroscience - and #geriatrics!

One key theme will be about biological mechanisms of aging as common drivers of chronic disease both in the brain and in the rest of the body, simultaneously. What are the gaps and opportunities to bring this #geroscience concept into clinical practice?

INTERSECTION OF MULTIPLE CHRONIC CONDITIONS (MCCS) AND ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE RELATED DEMENTIAS (AD/ADRD) Intersection of Multiple Chronic Conditions (MCCs) and Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) (2025)

We're kicking off an NIA-AGS symposium on the intersection of Alzheimer's disease and multiple chronic conditions - exactly the sort of interdisciplinary, un-siloed, patient-centered science that National Institute on Aging does so uniquely well! www.americangeriatrics.org/r13conference

YouTube video by Vivalon Learn How to Be Your Own Geriatrician - The Buck Institute for Research on Aging at Vivalon

Learn how to be your own geriatrician! Buck was thrilled to partner with Vivalon this week providing valuable info to older adults on how to best advocate for themselves in a medical system that often lets them down. Kudos to Dr. John Newman! www.youtube.com/watch?v=-6A-... @geriscidoc.bsky.social

Cuts to the VA research have been hard. I've lost colleagues, including one studying Veteran homelessness. But losing VA research hurts us all.
1/6
(I'm expressing my own views and not necessarily those of the VA or the US government.)

Well done, Jade and @serogersmd.bsky.social! What a fantastic NIH-funded MSTAR project.

📢 Save the date! The 2025 California Academic Geriatrics Institutions (CAGI) Conference is happening May 30 at UC Irvine. Join geriatrics professionals from across CA to connect & collaborate. Coordinated with support from Drs. Todd James (@Geri_IPE) & @susanschneiderucsf.bsky.social! #CAGI2025

YouTube video by Buck Institute for Research on Aging Eric Verdin, MD, President of the Buck Institute in hearing of the Senate Special Committee on Aging

Our CEO, Eric Verdin answered questions about the administration’s proposed budget cuts to the NIH at a hearing before the Senate Special Committee on Aging this afternoon. Hear his exchange with Angela Alsobrook D-MD here: youtu.be/XrhHldez1AI

Just two more days to apply to UCSF MSTAR! Applications due Friday Feb 14. A unique opportunity for medical students to immerse themselves in aging research!

Calling all medical students - aging research needs you! Apply now for UCSF 2025 MSTAR summer research program. Learn from all-star mentors how to solve the most meaningful and complex problems facing society. Apps open now, due Feb 14. #Geriatrics #Aging geriatrics.ucsf.edu/education/me...

Lots more details on the UCSF MSTAR website, including instructions and tips to write a strong application. We're looking for students passionate about aging research and care of older adults. Join MSTAR!

MSTAR includes summer research support, lecture series, meet-the-profs discussions, a symposium for you, and clinical shadowing in geriatric medicine. You can even co-mentor a high school student. And you will submit your data to present at the national #AGS meeting!

MSTAR projects span the entire aging research field, basic science to clinical research, quantitative to qualitative. Over 70 volunteer faculty mentors, including geriatricians, geroscientists, dermatologists, intensivists, & many other subspecialists who focus on older adults.

Calling all medical students - aging research needs you! Apply now for UCSF 2025 MSTAR summer research program. Learn from all-star mentors how to solve the most meaningful and complex problems facing society. Apps open now, due Feb 14. #Geriatrics #Aging geriatrics.ucsf.edu/education/me...

I strongly support the NIH Diversity Supplement Program. Addressing the severe lack of diversity among biomedical researchers improves the quality of research. It's not a level playing field. This program helps restore equity through mentored training. Rescinding this program is a big mistake

What other departments or divisions are doing faculty sessions on teaching how to get on BlueSky? @ucsfgeriatrics.bsky.social is! Thanks @lwaltermd.bsky.social for setting this up! #geriatrics #gerisky

Buck Institute and Phenome Health Awarded up to $52M from ARPA-H Award Aims to Transform Healthcare with Personalized Analytics

Thrilled to announce up to $52M award from ARPA_H for groundbreaking PATH program: Personalized Analytics for Transforming Health. Along with our strategic partner Phenome Health our aim is to predict and prevent diseases to increase individual #healthspan. www.buckinstitute.org/news/buck-in...

OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇
www.nature.com/articles/s41...
#GeroSky

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...

Ketone bodies: more than energy, they are powerful signaling metabolites that clean up damaged proteins Ketone esters help clear misfolded proteins in mouse models of aging and Alzheimer’s disease   Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular pro...

#Ketone bodies are not just about energy. Study in @cellpress.bsky.social shows metabolites are powerful signaling molecules that help clean up damaged proteins. New biology for aging and neurodegenerative disease @geriscidoc.bsky.social @sidmadhavan.bsky.social www.buckinstitute.org/news/ketone-...

We are all going to Alaska!! #AGE2025 as organized by the indomitable Ben Miller at OMRF @benjaminfmiller.bsky.social @americanaging.bsky.social @am-omrf.bsky.social

One generous gift from Dr. Jim Johnson started a snowball rolling, out of which grew the Buck Clinical Research Core. From one gift for one small study grew millions in funding for a half dozen or more geroscience clinical studies, and still growing. You can have an enormous impact! Thank you!

Thank you Buck Donors! This is "Thank you Buck Donors!" by The Buck Institute on Vimeo, the home for high quality videos and the people who love them.

During this season of giving, we want to express our thanks to our donors. We’ve created a special video featuring scientists from across the Buck, sharing how your contributions have helped make a big difference in our research. We are incredibly grateful for you!
vimeo.com/1009324677/d...

It's delirium! Not dementia.

Feel free to widely share the one-page flyer and web page linked below, created by the American Delirium Society. Post the flyer in resident work rooms. Build delirium awareness!

americandeliriumsociety.org/wp-content/u...
americandeliriumsociety.org/delirium-awa...

A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.