Kelsey H. Collins

Sporting mine in Sydney, Australia! Learn more about the #whitesneaker campaign and resources for #worldosteoporosisday below 👇🏻

Thrilled to be speaking at the McCaig International Research Conference on #Osteoarthritis, March 11–13, 2026 in Kananaskis, Alberta 🇨🇦
Trainee abstract submissions are open until Oct 31, 2025!
Learn more: mccaig.ucalgary.ca/event/intern...
#McCaig2026 #BoneAndJointHealth

Love seeing the #WhiteSneakers being packed for #ASBMR2025, keep them coming! Wear them at the meeting on Saturday 06 Sept to Take Steps to Improve Bone Health. Even if you can't join us in Seattle, post a pic with your favorite pair and join the MOVEment! @asbmr.bsky.social 🦴💪🚶‍♀️🚶

The @asbmr.bsky.social Annual Meeting is less than 2 weeks away, and we're all lacing up our #whitesneakers to get ready! Wanna join the MOVEment and Take Steps to Improve Bone Health? Be sure to pack your white sneakers for #ASBMR2025 in Seattle, wear them on 06 Sept, and stay tuned for more!

We are inviting original research studies that probe the interaction between Obesity and Osteoarthritis for
@oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss!

@jointsintheworld.bsky.social
@profdavidhunter.bsky.social
@larhumato.bsky.social
Shannon Mihalko
Henning Bliddal

Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice - Arthritis Research & Therapy Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the under...

Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....

Thanks, Ardem! Great work by Erica Ely, former PhD student in the Guilak Lab, which was a lot of fun. Stay tuned for her work on high-fat diet and arthritis!

Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....

Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk Objectives To reveal causal level osteoarthritis (OA) disease biology by targeting regulatory interactions at GDF5. Methods By investigating different GDF5 regulatory regions (R2, R3-5, R7-R9, R18...

1) Despite the chaos, I am very pleased to present the terrific research conducted by my post-doc @clarissacoveney.bsky.social. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

And fat mass differences!

It is a joy to congratulate @jessicagwagner.bsky.social, Movement Science PhD Student in UCSF PT, on a fantastic qualifying exam this morning - first one in the lab! Way to go, Jess 👏

Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....

Starting in 15 min! Thanks @jointsintheworld.bsky.social and CCOMP for the opportunity to share our work @farsh-g.bsky.social

New to ORS? Join our New Member Orientation on May 21 at 12 PM CST via Zoom! Learn about member benefits, networking, and hear how ORS has impacted careers. Bring your questions!
🔗 Register now: bit.ly/3XzipIA

Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!

www.science.org/doi/full/10....

@kelseyhcollins.bsky.social and I are kicking off the USASP Annual Scientific Meeting with a trip to the iconic Bean! Excited to be in Chicago, present my work this afternoon at poster B28, and join the Pain & Aging SIG tonight! 🎉

@usasp.bsky.social

Thank you!

Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ

Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!

Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity This randomized clinical trial assesses the effect of metformin on knee pain among patients with symptomatic knee osteoarthritis and overweight or obesity.

Yet another study showing beneficial effects of metformin for pain - this time in OA pain. Effects on pain are modest, but better than placebo. Effects on WOMAC scores are more impressive. Also no sex differences observed. jamanetwork.com/journals/jam...

Congratulations to @grainofscience.bsky.social on the 2025 OARSI Rising Star Award! Well deserved 👏

If you're around Palo Alto tomorrow, come hear how we gave menisci discarded from the food industry a second life to repair tracheas and eardrums @bioe-stanford.bsky.social @pennmedicine.bsky.social @pennengineering.bsky.social @upenn.edu #ENT

Obesity has a distinct impact on the progression of OA. We showed significant loss of protective synovial lining macrophages in the synovium 3 days after joint injury, with a significant restoration in normal-weight but not in obese mice @farsh-g.bsky.social
ard.eular.org/article/S000...

Meningeal regulatory T cells inhibit nociception in female mice T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (Treg cells) could inhibit nocic...

Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...

A timely assessment of the state of transcriptomic and epigenomic profiling in OA: Opportunities for advancements

Our Editorial is now online! Here, we discuss recent advancements and pertinent challenges in applying modern 'omics technologies to MSK tissues. This introduces our @oacjournal.bsky.social special edition. Still ~4 weeks left if you have a paper in the works! www.sciencedirect.com/science/arti...

Want to do a #postdoc? Did you know more faculty jobs go to people who postdoc in slightly different subject area? doi.org/10.1073/pnas... Are you an expert in #microbiome OR #osteoarthritis? How'd you like to join me and @kelseyhcollins.bsky.social as we figure out how the two are connected?

Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵

www.nature.com/articles/s41...

Hey #CartilageGRS2025 trainees! Defending soon, looking for a postdoc, and/or want to live in beautiful San Francisco, CA? We're looking for motivated folks to solve complex puzzles involving systemic factors, fat, aging, the gut microbiome and MSK health. DMs open! @thehopefulscie1.bsky.social

Stop 4: Solvang (forgot to take any photos- sign of a good time)

Stop 5: In N Out (aka when in Cali) #CartilageGRC

This may be the only photo we managed in the matching outfits! Thank you for documenting 😂