Aubry K. Miller

Now I have a goal. 😉

When is a Monomer not a Monomer? The Top Three Ways Your Favorite Fluorescent Protein Oligomerizes in Cells Many commonly used fluorescent proteins form dimers producing artifacts in a variety of experimental settings. Learn how to avoid these artifacts.

💡 Always a good time to be reminded: "if you fuse your protein of interest to GFP or EGFP to study the protein's behavior ... you are using a tag with a serious drawback."
Same goes for anything that doesn't have 'm' in its name (looking at you, dTomato and StayGold)

Very glad to hear…but not surprised. 😉

Congrats, Alex!

A PhD student from the group is there. Keep an eye out for Nick Richert…he will also give a short talk. Enjoy!!!!

yum

Ouch

Proton Pump Inhibitors Do More Than You Think

I can't believe I missed @dereklowe.bsky.social commenting on our @natchem.nature.com a month ago at "In the Pipeline". I've dreamt for many years that Derek would choose to highlight work coming out of the lab. That feels like a real stamp of approval. Thanks, Derek! www.science.org/content/blog...

You purchased it of course

Our Synthetic Genomics Center "SynGen" is looking for a coordinator, located at @kit.edu Karlsruhe, but coordinating also the U Heidelberg and U Mainz sites.

We are hoping to fill this vacancy ASAP.

For further info, please visit:
www.syn-gen.de/en
www.pse.kit.edu/english/karr...

Please share 🙏

Oh, you figured out what it was. So cool!

What a disappointment

The most recent roadmap problem from our Synthesis Club is up on our shiny new website. This quiz highlights the synthesis of clionastatin B from the group of Jinghuan Gui. www.dkfz.de/en/cancer-dr...

Site-specific activation of the proton pump inhibitor rabeprazole by tetrathiolate zinc centres - Nature Chemistry Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment of the stomach lining. Now, coordination of PPIs to protein-bound zinc ions is revealed as...

Check out our paper on proton pump inhibitor activation (PPI) in cells in Nature Chemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@redoxdkfz.bsky.social). More collabs between our groups to come! doi.org/10.1038/s415...

DKFZ Innovation Management on LinkedIn: #collaboration #innovation #cancerresearch #academicindustrypartnership… Targeting hallmarks of cancer 👏 We are pleased to announce that the project of Dr Nikolas Gunkel of the DKFZ German Cancer Research Center has been awarded a…

Congrats to Niki and the whole team for this new collaboration with Sanofi.
www.linkedin.com/posts/dkfz-i...

Great opportunity to work with an excellent young group leader.

I fully support the name change.

Integrating non-natives. How dare you.

From Dorothea Fiedler's lab: Protein polyphosphorylation as a new post-translational modification www.biorxiv.org/content/10.1...

I could definitely adapt to calling formic acid "HAKOO" before getting used to Randall's drawing of it.

This week’s Synthesis Club quiz featured a total synthesis that one of our recent Master’s students contributed to as an intern in the US. Anyone recognize this beauty?

I saw this article this morning and immediately bought her book. Looking forward to it.

I had no idea Rodney Mullen, the Godfather of skateboarding, had studied Chemical Engineering. Thanks, Rodney, for putting two of my favorite things together on one slide. youtu.be/2c3aXbwM8L0?...

Congratulations, David!

A General Entry to Ganoderma Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone B, Meroapplanin B, and Lingzhiol Ganoderma meroterpenoids are fungal derived hybrid natural product class containing a 1,2,4-trisubstituted benzene ring and a polycyclic terpenoid part. The representatives applanatumol E, H and I, li...

The natural product is lingzhiol, and we studied Magauer's recent manuscript, which included the synthesis of five other Ganoderma meroterpenoids: doi.org/10.1021/acs.orglett.4c03192

Can you add me to this starter pack please? Thank you!

Not my fault. 😂

Starting what will hopefully become a regular feature here…our disconnection analysis of a natural product total synthesis from our biweekly Synthesis Club meetings. Anyone recognize this recent beauty? #chemsky

Definitely keeping my fingers crossed!

Sounds like fun to me!