Andrea Testa

Today's Bioorganic bingo 😂

Labour seems determined to elevate Farage and Faragism- they should stop. And why Starmer is "better"at foreign policy than domestic

In two important ways Labour empowered Nigel Farage and Faragism this week. Both were strategic mistakes. We’ve seen this story before.

New writing from me.

open.substack.com/pub/goodalla...

Not a bad commute to work.. 🚲

Nice timing to introduce @trimtech.bsky.social on this platform! Learn more about @trimtech.bsky.social foundational science here:

Congratulations Rich! 🎉🎉

A Bifunctional Degrader Reads Out in Phase 3

The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:

And that's us! The news is out! #TRIMTECH

Thanks for sharing, Dan!! 🙏

Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...

Wishing everyone a happy new year, pushing forward our science, hobbies and passions, surrounded by people we enjoy spending time with!

Amazing work!! Congratulations @alessiociulli.bsky.social and @alesalerno.bsky.social 💡🥂

Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants.
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity - Nature Communications The authors show that DCAF1, a substrate receptor of CUL4 and EDVP E3 ligases, can be recruited by PROTACs to degrade the cancer drug target, WDR5. They also report the crystal structures of PROTAC te...

Fantastic to see more ternary complex structures of #PROTACs recruiting novel E3 ligases!! www.nature.com/articles/s41...

Hi Jordan, can you add me to the list please? Feel like I've degraded BRD4 quite a lot in the last 10 years 🤣

Randomly meeting friends from #Dundee in Hong Kong airport 🥰🥰🥰

First post on here, on my way back from a fantastic #TPD conference in Shenzhen, China. Great science and a level of engagement well above expectations! Thanks for having me!!