Jun

Deng, Thorn et al. @sydney.edu.au report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. rupress.org/jcb/article/...

#CellSignaling #Physiology

We're starting the "Night Science Seminar Series" where the notion is that as you talk about your science, as in a regular talk, there's is also a slide labeled “A Night Science Moment” to discuss how the idea came about. I'll go first on Sept 22 - Join us virtually!
cassyni.com/events/ApfsK...

The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...

I had to fight to stay in science. Perseverance should be valued Those who’ve taken a slower, bumpier path deserve a closer look, this researcher writes

www.science.org/content/arti...

All a worm researcher wants for Christmas:

How I finally found my confidence as a scientist After three postdoc positions, this researcher now sees her skills and knowledge as valuable

How I finally found my confidence as a scientist | Science | AAAS www.science.org/content/arti...

NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse po... A core facet of the National Institute on Aging’s mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward th...

Big overview of more than a decade of hard work: NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
link.springer.com/article/10.1...

I am excited to share that the project that taught me how to do science is now published at Journal of Cell Biology @jcb.org.

Cytoplasmic flow is a cell size sensor that scales anaphase - Nature Cell Biology Afonso et al. show that, during anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby...

☕️Afonso et al. show that, during #anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby scaling anaphase.
bit.ly/41k8XsG

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...

The controls that got out of control: How failed control experiments paved the way to transformative discoveries: EMBO reports: Vol 0, No 0 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org/doi/full/10....

Workshop Applications - 25th International Worm Meeting Visit our website to learn more.

With how busy the start of the semester is, the #Worm25 organizers have announced an extension of the deadline to apply to organize a workshop at the conference!📣 You now have until January 31.

Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱

Science and writing, thinking and rethinking

Open Access
www.cell.com/matter/fullt...

It's that time of year. Confocal + Christmas = Xmas Tree, Ymas Tree, and our favorite Zmas tree. #microscopy #confocal #imaging

C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions https://www.biorxiv.org/content/10.1101/2024.12.01.625591v1 Huntingtin (HTT) is the gene responsible for the Huntington disease (HD), a neurodegenerative disord

C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions https://www.biorxiv.org/content/10.1101/2024.12.01.625591v1

Inheritance: Leaving sticky notes for the children It is currently unknown to what degree parents’ life history can affect the next generation and how such information might be transmitted. A new study finds that nematodes transmit amyloid proteins to...

Big thanks to @odedrechavi.bsky.social and @ethanewe.bsky.social for the Dispatch in @currentbiology.bsky.social on our amyloid inheritance paper. www.cell.com/current-biol...

Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...

🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...

It's a big relief getting to know the C Elegans labs gotten funded downunder. Congratulations to them all!

In my first real post I want to show the key experiment that revealed to me what I want my own lab to be about:
The conversion of phosphoinositides!
By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K

Conflict during learning reconfigures the neural representation of positive valence and approach behavior How are positive and negative experiences integrated during learning? Here, Molina-García, Colinas-Fischer, et al. find that the neuropeptide PDF-1 encodes both experiences by being released from and ...

New study from Arantza Barrios' lab shows that valence of stimuli is flexibly encoded in the nervous system of C. elegans as they wiggle forward or backward... 🧪🪱
#neuroscience #behavior www.cell.com/current-biol...