Paul Macklin

Lewis Black Unaccompanied Minors GIF ALT: Lewis Black Unaccompanied Minors GIF

Last rant (for the day) about the "Reclaiming Science" MAHA event.

Deputy Director Memoli (who was described as running NIH inside whereas Director Bhattacharya handles external issues [Narrator: Normally, the NIH Director does not delegate NIH management] participated in a panel discussion.

1/16

That's just outstanding.

Best I've seen so far is "A Fistful of Sausages." :-)

@zaphodbeebledoc.bsky.social had this, and a few others.

*sniggering*

Continuing a meme: Ruin a movie by replacing one word in the title with "Sausage".

Here are a few:

My Sausage Lady
Snow White and the Seven Sausages
A Sausage Named Desire

Isn't sand basically defined as fine-grained rock/mineral material? (Smaller than pebbles, coarser than silt and clay)

And bassalt-based black sand is a definitely a thing on Earth that people pay tourism dollars to see while calling it sand! :-)

I guess Earth's black sand beaches don't have sand then! :-)

Oh no!!!

broken impeller on an LG washer drain pump

broken impeller on an LG washer drain pump

Well, that ain't gonna' work!

Now that that snow removal's done, naturally the washer failed to drain. After siphoning the water out with leftover aquarium gear and disassembling, I see the impeller completely sheared off the rusted shaft.

Pump is out of production at LG, but $50 on ebay.

Snow in Bloomington, IN

Clearing snow is fun!

Just a little snow here! I measured it at about 15 inches. #snow #snowstorm

Oof, and definitely!

I sneaked in one last very cold run Saturday morning ahead of our 13-14". Hope you're staying safe and warm!

Fierce snowcorgi.

Part of her majesty's personal snow path.

This not-spoiled, brave Corgi refused to go potty until I had dug out a path across the deck and 15 feet into the yard. #snow #snowstorm

leaf blower could do the trick at this early point.

Ep 23 - So what actually IS CellPainting anyway? You may have heard of it if you're say, a fan of the @drannecarpenter.bsky.social - @shantanu-singh.cc lab (and who isn't????), but what, you know, is it? Let @erinweisbart.bsky.social break it down for you!

youtu.be/9-d6DoHtgUY

What a wonderful night 🤩
The strongest solar storm in over 20 years produced an amazing show for hours. 🧪🔭

Wow! Fantastic photos, too!

A not at all spoiled Corgi

Ours says "Where's my greenie, hyoomon?"

Our Corgi would agree and approve

AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape @natcomms.nature.com
www.nature.com/articles/s41...

A Muller plot generated by ggmuller. The horizontal axis is time, and shapes of different colours represent genotypes (or other subtypes), with height corresponding to genotype frequency (or relative abundance) at the corresponding time point. Descendant genotypes are shown emerging from inside their parents. In this example, colour represents relative fitness.

In 2017 I created the ggmuller R pacakge to draw "Muller plots" combining phylogeny and frequency dynamics. The latest version 0.7.0 fixes deprecated dependencies and includes a few other minor improvements.
CRAN: cran.r-project.org/web/packages...
Vignette: cran.r-project.org/web/packages...

Holy shit that's a good first 11 seconds!

Looking good!!

Mammary Alveolar Proliferation and Differentiation During Early Pregnancy is Regulated by E2F5 The E2F transcription factors are well-established cell cycle regulators, but their roles in coordinating proliferation and differentiation remain poorly understood. Here, we investigated the function...

Third preprint from the lab in as many weeks... this time, the loss of transcriptional control of early pregnancy by E2F5 results in alveolar defects. www.biorxiv.org/content/10.1...

Hey, @drdorotask.bsky.social is here on Bsky!

Such cool work.

We think that retinas degenerate with time and that if all of us live long enough, we’ll get AMD or other neurodegenerative diseases.

But Greenland sharks manage to live for hundreds of years and repair their eyes.

How?

Our Solar System is orbiting the center of our Galaxy at about 220 km/s so in 2025 we collectively traveled something like 7 billion kilometers across the Milky Way. Once in a while, when you have a moment, it’s worthwhile to take a look around, see where you are, and appreciate how far you’ve come.

Looking good, Iowa!

(Disclosure: Science was on the cover, but our Cell cover submission wasn't selected. I liked it anyway. :-) )

Office wall with 2025 Science and Cell publications, and prior astrophotography.

Science cover (2025), integrating our smart phone app for community eclipse science (over 11,000 observations across North America!) with AI analysis of audio recordings across Monroe county to detect changes in bird behavior during the eclipse. Work led by Liz Aguilar, joint with Kim Rosvall and Dustin Reichard.

Cell article (2025) and cover submission, on our new cell behavior grammar to enable rapid, intuitive, and interpretable simulation models of complex cell systems. Work led by Jeanette Johnson, Daniel Bergman, and Heber Rocha, jointly with Elana Fertig, Lisa Coussens, Laura Heiser, Genevieve Stein-O'Brien, and Young Hwan-Chang.

New office decorating :-) #mathbio #mathonco 🧪

Thanks for a great 2025, @fertiglab.bsky.social @coussenslab.bsky.social @jeanettejohnson.bsky.social @heberlr.bsky.social @liz-aguilar.bsky.social @rosvall-lab.bsky.social @juncowren.bsky.social & amazing collabs!

Here's to new adventures in 2026!

Methodology should also generalize to cover naughty and nice acts on Santa's list.

Equivalence to points in the Good/Bad place to be determined.

In the past ten years, I have been blown away by the amazing things we can accomplish as research communities when we commit to sharing code, data, and expertise.

Huge shout-out to @drmarcoruscone.bsky.social and Adam Šmelko! Amazing work!! 2/2

#OpenSource for the win! #mathbio #mathonco 🧪

Our amazing collaborators at @bsc-cns.bsky.social are showing 50x speedups in @physicell.bsky.social after their deep analysis and optimization work. Code reviews and releases coming soon! :-) 1/2