ADA Professional Publications

Illustration of a scientific study on a male obese mouse expressing leptin receptors in adipocytes. The diagram highlights the impact of leptin on brown adipose tissue, indicating increased vascular density and various associated molecular pathways such as VEGFA, ANGPT1, and TGF-β. It also references related health indicators like HbA1c levels, insulin sensitivity, blood pressure, arterial stiffness, and endothelial-dependent relaxation.

BAT leptin signaling plays crucial role in regulating energy expenditure and glycemic and cardiovascular health, primarily in males.

Read here ➡️ doi.org/10.2337/db25-0388

Scientific diagram illustrating a study on vagal innervation of pancreatic targets. The image consists of four main sections: Context, Method, Results, and Intracellular Ca²⁺ imaging details. The 'Context' panel shows connections between the brain, pancreas, and pancreatic targets. The 'Method' section depicts mouse models and pancreatic imaging techniques. The 'Results' panel explains outcomes using intracellular calcium imaging and response mechanisms. The final panel provides detailed views of cellular responses to vagal stimulation. Each section includes relevant scientific icons and models to represent the processes studied.

Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function

Read here ➡️ doi.org/10.2337/db25-0604

The cover of DOCM Care, featuring illustrations of healthcare professionals, a beaker, and a microscope against a blue backdrop, all framed with a heart-shaped wreath.

Excited to share the 1st issue of Diabetes, Obesity, and Cardiometabolic CARE (DOCM CARE) — a new ADA journal with a practical, person-centered focus.

Highlights include obesity treatment standards, technology equity, CGM adoption, and real-world case studies.

diabetesjournals.org/docm-care

The image is an infographic about SGLT2i effects on urate-lowering and gout flare therapies. It includes a graph showing gout flare rates comparing DPP-4i and GLP-1RA over 36 months of follow-up. Key points mention SGLT2i's association with reduced gout flare rates and lower use of urate-lowering agents. A note highlights the pleiotropic benefits of SGLT2i for polypharmacy reduction and CKM comorbidity care.

SGLT2i use associated with lower ULT, NSAID, high-dose glucocorticoid and diuretic use among gout patients, along with fewer flares. Implications for improving gout & cardiometabolic comorbidity care.

Read here ➡️ doi.org/10.2337/dc25-1713

📚 NEW: 2025-26 Guide to Diabetes Medications—complete reference for clinicians. All drug classes + comorbidity management.
📖 Chapters: doi.org/10.2337/978158040846
🛒 Print: shopdiabetes.org/collections/professional-books/products/2025-26-guide-to-medications-for-the-treatment-of-diabetes-mellitus

This special edition of Diabetes Core Update is sponsored with support from @novonordisk.bsky.social

🚨 NEW special #podcast

In the latest ep of our What's Next series, Neil Skolnik discusses Semaglutide, the first GLP-1 receptor agonist to receive FDA approval.

👂 Listen now at: diabetesjournals.org/journals/pages/podcasts_whats_next

Cover of the January-February issue of Diabetes, Obesity, and Cardiometabolic Care journal, featuring a stylized illustration with various medical professionals and elements related to healthcare on a blue background, marked as new.

New journal for interdisciplinary care teams! Clinical guidance, obesity care, behavioral science & cardiometabolic insights in one resource. 🌟 Online now | Print Feb 2026. 👉 Explore & subscribe: diabetesjournals.org/docm-care

Illustrative diagram of the biochemical processes involved in ferroptosis, highlighting key components like Ang-II, SP1, DPEP1, SLC3A2, GSH, and ACSL4, and their interactions in the context of lipid peroxidation, glutamate regulation, and iron storage.

DPEP1 is a novel mediator of kidney injury! Our study in Diabetes reveals that AngII promotes ferroptosis in kidney cells via SP1-DPEP1-SLC3A2 axis. Targeting this pathway with cilastatin blocked ferroptosis and protected kidney function.

Read here ➡️ doi.org/10.2337/db25-0619

This infographic is titled "Medication Adherence in Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)." It details a study on medication adherence over three years, showing a decrease from 88.7 to 67.9. Participants were randomized to medication groups, and adherence was linked to better glycemic control. Key measurements include HbA1c levels, with outcomes highlighted for different medications like Metformin, Glimepiride, Sitagliptin, and Insulin Glargine. Icons and graphs illustrate findings.

Patient-reported adherence to glucose-lowering medications was initially high, decreased over 3 years and robustly predicted glycemic outcomes among 1739 adults with T2DM in the GRADE study.

Read here ➡️ doi.org/10.2337/dc25-2008

An infographic showing two cohorts for obesity research, labeled "Discovery cohort" and "Validation cohort". Each section includes diagrams of human figures representing different BMI groups and health parameters such as BMI, HOMA-IR, and HOMA2-B. The Discovery cohort consists of 406 individuals, while the Validation cohort includes 311 individuals. Both sections detail subgroup categorizations using k-means clustering and metabolic profiling methods to identify different obesity-related health risks.

Cluster Analysis of Younger-Onset Type 2 Diabetes in an Asian Cohort Reveals Distinct Subgroups With Differential Pathophysiology and Outcomes

Read here ➡️ doi.org/10.2337/db25-0871

Over four in ten individuals with diabetes globally are undiagnosed. Substantial variability in undiagnosed diabetes across countries can indicate opportunities to close existing care gaps.

Read here ➡️ doi.org/10.2337/dc25-2583

Infographic comparing dietary and exercise determinants of type 1 diabetes during pregnancy with and without type 1 diabetes. It includes two sections for pregnant individuals, one with type 1 diabetes and one without, showing the frequency and type of food intake like carbohydrate types and fat sources, as well as physical activity levels. Visual icons represent exercise intensity and food categories.

Diet intake and physical activity in #pregnancy were similar for women with and without #type1diabetes, but overall suboptimal. #ENDIAstudy

Read here ➡️ doi.org/10.2337/dc25-2064

The Impact of Ancestry on Performance of Type 1 Diabetes Genetic Risk Scores: High Discrimination Performance Is Maintained in African Ancestry Populations; Population-Specific Thresholds May Impr... Steven Squires, Jean Claude Katte, Dana Dabelea, Catherine Pihoker, Jasmin Divers, Eugene Sobngwi, Moffat J. Nyirenda, Raymond J. Kreienkamp, Angela D. Lie

We compared the performance of type 1 diabetes genetic risk scores (GRS) on diverse populations. One GRS showed good performance across ancestries, but high-risk thresholds might need to be varied.

Read here ➡️ doi.org/10.2337/dc25-1833

Infographic titled 'Assessing Diabetes Risk Predictions in East Asian Adults.' It includes various sections with graphics and charts detailing genetic factors, environmental factors, and study data from cohorts in Taiwan and Japan. Highlights include discussions on Type 2 Diabetes risk, polygenic risk scores, and analyses of different predictive models for East Asian populations. The visual presentation utilizes icons, such as DNA strands, pie charts, and bar graphs to represent data and findings.

Integrating polygenic risk scores and family history may enhance diabetes risk prediction in East Asian populations.

Read here ➡️ doi.org/10.2337/db25-0357

The DiabetesBio logo, featuring a red microscope graphic and the insignia of the American Diabetes Association.

🚨 New for February, a fresh episode of the #DiabetesBio #podcast!

Featuring:
✨ B Lymphocytes & islet tolerance
✨ Weight loss & postprandial glucose disposal
✨ + Sweet Talk w/ @stephenorahilly.bsky.social

🎙️Listen at: diabetesbio.libsyn.com
📚Read more: diabetesjournals.org/diabetes/issue/75/2

An informative diagram showing the comparison between intensive lifestyle intervention and diabetes support and education on the prevention of peripheral neuropathy in type 2 diabetes subgroups. The chart includes methods, results, and conclusions, with visual elements like stick figures and a representation of a foot to signify peripheral neuropathy.

First evidence in support of type 2 diabetes subgrouping that shows differential risk for peripheral neuropathy by T2D subgroup.

Read here ➡️ doi.org/10.2337/doc25-0051

Infographic displaying research on the relationship between hypoglycemia exposure and symptom recognition. Titled sections include Background, Methods, and Results with charts and percentages such as 717 participants, 54% female. Sections also display methodological details involving adults with Type 1 Diabetes from T1D Exchange registry, and summarizes findings with visual graphs and statistical data.

Hypoglycemia lowers the glucose level for symptom recognition in diabetes, contributing to impaired awareness of hypoglycemia. Interoception may mitigate this effect and help preserve awareness.

Read here ➡️ doi.org/10.2337/dc25-2242

Overview of the DIAP-I model in an endoscopy unit, showing a three-step diagram on how DIAP-I works, including clinical entry, decision support by a personalized care team, and treatment generation. Below, a study comparison between physician-directed control vs DIAP-I directed care is displayed with results indicating efficacy and adverse effects. The entire process emphasizes patient and technology integration in clinical decision-making.

DIAPI, a web-based tool generating personalized directives, offers a safe, effective and reliable way to simplify peri-procedural diabetes management in endoscopy units.

Read free in Diabetes, Obesity, and Cardiometabolic CARE ➡️ doi.org/10.2337/doc25-0060

A "listen and subscribe" call to action for the Diabetes Care On Air podcast, featuring black and white images of hosts Alice Cheng and Mike Rickels, an image of a microphone, and the insignia of the American Diabetes Association.

🚨 A new month, a new Care on Air! Where #podcast hosts Mike & Alice discuss the latest issue Diabetes Care.

🎧 https://diabetescareonair.libsyn.com/site

In this ep:
✨Untold histories of diabetes
✨Longitudinal effects of glucose-lowering agents
✨& more!

Full issue ➡️
diabetesjournals.org/care

This special series is sponsored by Insulet.

🚨 NEW special #podcast

In part 3 of our series on automated insulin delivery & T2D, we explore questions that arise when prescribing this cutting-edge treatment.

👂 Listen now at: diabetesjournals.org/journals/pages/podcasts_aid_t2d

Flowchart illustrating the study design and findings linking insulin sensitivity, secretion, and dose in Type 2 Diabetes research from the German Diabetes Study with depiction of different medical tests and factors like FVC, HOMA-IR, and spirometry.

Lower insulin sensitivity & clearance may contribute to pulmonary function alterations in diabetes.

Read here ➡️ doi.org/10.2337/dc25-2334

Graphical comparison showing the effects of using automated insulin delivery systems on insulin dosage and weight loss in 36 adults with type 1 diabetes and obesity over a 26-week period. The left graph displays percentage reductions in bolus and basal insulin at 4 and 26 weeks. The right graph shows the percentage of total weight loss attributed to direct medication effects and weight loss across weeks 4, 20, and 26.

In adults with type 1 diabetes, semaglutide produced rapid, sustained, and primarily bolus-driven insulin dose reductions, which is weight loss independent initially and becomes weight loss dependent.

Read here ➡️ doi.org/10.2337/dc25-2249

Cover of the January-February issue of Diabetes, Obesity, and Cardiometabolic Care journal, featuring a stylized illustration with various medical professionals and elements related to healthcare on a blue background, marked as new.

New journal for interdisciplinary care teams! Clinical guidance, obesity care, behavioral science & cardiometabolic insights in one resource. 🌟 Online now | Print Feb 2026. 👉 Explore & subscribe: diabetesjournals.org/docm-care

A syringe drawing liquid from a vial, with a "Diabetes Core Update" graphic in the lower right corner.

💉 Catch up on this Diabetes Core Update episode! Dr. Skolnik & guests cover respiratory vaccines for diabetes patients, vaccine hesitancy trends, and practical strategies to address patient concerns in your practice.

🎙️Listen at: diabetesjournals.org/journals/pages/podcasts_vaccines

This image is a diagram comparing insulin-sensitive and insulin-resistant states. On the left, the insulin-sensitive state shows GLUT4 transporters moving to the cell surface, facilitated by GLUT4 storage vesicles (GSV) and TUG protein. On the right, the insulin-resistant state depicts a reduction in GLUT4 transporter surface movement and storage vesicles near the cell membrane. The diagram uses arrows and text labels for clarification.

TUG may provide an important pharmacologic target in the treatment or prevention of metabolic dysfunction in patients with obesity.

Read here ➡️ doi.org/10.2337/db25-0488

Flowchart titled 'The Potential Impact of Large-Scale Weight Loss Early After Type 2 Diabetes Diagnosis on Lifestyle and Incretin-Based Weight Loss Modalities: The Future of Type 2 Diabetes Care?' showing the positive impacts of early weight loss, including improved metabolic rates and reduced inflammation, and comparing lifestyle change results with incretin-based methods over a hypothetical 3-5-year timeline. It includes pathways of various tests and health-related quality-of-life metrics, with a note on compliance assumptions.

Evidence to support why early, large-scale weight loss via incretin therapies could be the future of type 2 diabetes care

Read here ➡️ doi.org/10.2337/dci25-0069

Diabetes care requires a team effort, including pharmacists. Creating a structured postgraduate program and certifying diabetology pharmacists can fill current gaps in diabetes management.

Free to read in Diabetes, Obesity, and Cardiometabolic CARE ➡️ doi.org/10.2337/doc25-0049

Infographic explaining how Soluble Urokinase Plasminogen Activator Receptor (suPAR) mediates the impact of type 2 diabetes on cardiovascular adverse events in a study with 4,324 participants with stable CHD. The graphic includes statistical data, line graphs showing survival rates over years, and flowcharts describing the percentage of effects mediated by suPAR.

T2D raises CHD risk mainly via chronic inflammation measured by suPAR, not hs-CRP. Targeting suPAR could improve outcomes. Study in 4,324 patients over 6.9 years.

Read here ➡️ doi.org/10.2337/dc25-0940