ADA Professional Publications

Infographic showing how prescriptions for new Type 2 Diabetes classes increased over time for older patients with expanded Medi-Cal coverage in California. The left graph displays rising predicted probabilities of SGLT2 inhibitor or GLP-1RA prescriptions, with a notable increase in May 2022. The right panel explains that undocumented immigrants became newly eligible for Medi-Cal in June 2023, leading to similar prescription rates for these newer diabetes treatments compared to other groups. A small map of the United States highlighting California is in the top right corner.

CA’s 2022 MediCal expansion for undocumented 50+ led to more prescriptions for newer T2D meds. Prescriptions for undocumented patients matched documented levels by June 2023. #MediCalExpansion

Read here ➡️ doi.org/10.2337/dc25-0787

A graphic illustrating low-carb diets of varying macronutrient quality with type 2 diabetes risk

Low-Carbohydrate Diets of Varying Macronutrient Quality and Risk of Type 2 Diabetes in Three U.S. Prospective Cohort Studies

Read more ➡️ doi.org/10.2337/dc25-1401

Infographic titled 'Personalized CGM Optimization Improves Accuracy, Enabling Safer Use in Inpatient Diabetes Care'. It consists of three sections: 'Inpatient CGM Data Collection', 'Machine Learning Optimization', and 'Combined Time Lag Results'. The first section shows a flow chart describing CGM data input from glucose measurements. The middle section includes diagrams illustrating machine learning methods for CGM signal time lag optimization. The last section highlights bar graphs comparing data accuracy improvements and clinical impact. Icons and text used are simple and relate clearly to the respective topics discussed.

Patient-specific CGM data optimization reduced MARD by up to 5.6% in patients, boosting accuracy and supporting safer clinical use in hospitals. Personalized algorithms may enable broader CGM adoption.

Read here ➡️ doi.org/10.2337/dc25-1494

Infographic titled "What you eat may matter: Inflammatory and Insulinemic Dietary Patterns and Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes Mellitus (GDM): A Prospective Study of 4,174 Type 2 Diabetes after 18 Years of Follow-up". The graphic illustrates two dietary patterns, EDIP and EDII, and their impacts on chronic inflammation and insulin resistance linked to type 2 diabetes. Elements include lists of foods under each pattern, icons representing health impacts, and visual flows indicating consequences like lipid levels and C-reactive protein (CRP) levels. The background is white with blue and pink colors highlighting different sections.

What you eat matters! New research shows proinflammatory and hyperinsulinemic diets increase the risk of type 2 diabetes and link to an unfavorable cardio-metabolic profile in women with prior GDM.

Read here ➡️ doi.org/10.2337/dc25-1919

🚨 NEW special #podcast of Diabetes Core Update, where host Neil Skolnik explores the cutting-edge topic of automated insulin delivery for people with T2D.

👂 Listen now at: diabetesjournals.org/journals/pages/podcasts_aid_t2d

This special edition of Diabetes Core Update is sponsored by Insulet.

A graphical abstract illustrating normal glucose

Dual-Input Regulation of β-Cell Proliferation by ATF6α and Glucose via E2F1

Reads more ➡️ doi.org/10.2337/db25-0279

Also, check out the rest of the great articles in the @adapubs.bsky.social Diabtes Care Special Collection relating to the symposium on How to Fix a Broken Healthcare System at the 2025 @amdiabetesassn.bsky.social ADA Scientific Sessions #diabetes

Infographic illustrating phenotypic clustering of youth-onset Type 2 diabetes, comparing simple clinical measures for predicting outcomes in the TODAY and SEARCH Study cohorts. The left side shows Cluster 1, 2, and 3 with associated variables like BMI z-score and HbA1c. The right side depicts clinical measures such as hemoglobin A1c, BMI z-score, and blood pressure, linked to predicting disease progression and complications. Icons represent blood test, blood pressure cuff, and organ health.

Two phenotypic clustering approaches in youth-onset type 2 diabetes reveal novel reproducible type 2 diabetes clusters but offer no added prognostic value to simple clinical measures.

Read here ➡️ doi.org/10.2337/dc25-1765

Image titled 'A' shows the back of a person's neck with a visible scar and short black hair, 'B' and 'C' are microscopic slides of skin tissue samples.

Successful Treatment of Diabetic Scleredema With Corticosteroids, Mycophenolate Mofetil, and UVA Therapy

Read more ➡️ doi.org/10.2337/dc25-2272

Illustrative image for a medical research presentation titled "Listening to Hypoglycemia: Voice as a Biomarker for Hypoglycemia". The left side shows an icon of a smartphone and a stylized profile of a head with sound waves, implying voice analysis. The right side presents two graphs labeled a) and b), depicting AUROC performance metrics for different voice-based tasks in detecting acute hypoglycemic events.

Listening to hypoglycemia – machine learning detects hypoglycemia in people with diabetes using voice alone with high accuracy. Voice analysis may enable noninvasive hypoglycemia alerts. #Diabetes #AI

Read here ➡️ doi.org/10.2337/dc25-1680

✨The Standards of Care in Diabetes—2026 is here!✨
🔍 Discover key updates in diabetes technology, nutrition, pharmacotherapy, behavioral health, and more.
📖 Read now: diabetesjournals.org/care/issue/49/Supplement_1

#ADAStandards #DiabetesCare #Diabetes2026

The logo for the DiabetesBio podcast, featuring a red microscope graphic and the insignia of the American Diabetes Association.

🚨 New for December, a fresh episode of the #DiabetesBio #podcast!

Featuring:
✨ Altering lipid localization & cellular composition
✨ HLA immune presentation
✨ Plus! metabolic Sweet Talk

🎙️Listen at: diabetesbio.libsyn.com
📚Read more: diabetesjournals.org/diabetes/issue/74/12

A "listen and subscribe" call to action for the Diabetes Care On Air podcast, featuring a black and white image of hosts Mike and Alice and the insignia of the American Diabetes Association.

🚨 A new month, a new Care on Air! Where #podcast hosts Mike & Alice discuss the latest and greatest of Diabetes Care.

🎧 https://diabetescareonair.libsyn.com/site

In this ep:
✨ T2D remission
✨ T2D and hypercortisolism
✨ and more!

Read the full issue ➡️ diabetesjournals.org/care

A list of highlights from the linked article

Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring

Read more ➡️ doi.org/10.2337/db25-0603

A graphical abstract showing the Effects of Modern Glucose Monitoring and Insulin Delivery Technologies on Patient-Reported Outcomes and Experiences in Individuals With Type 1 Diabetes

A systematic review and meta-analysis of 81 studies shows that diabetes technologies positively impact treatment satisfaction, hypoglycemia fear and diabetes distress in adults with type 1 diabetes.

Read more ➡️ doi.org/10.2337/dc25-1178

A graphical abstract illustrating how miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis

miR-432 Exacerbates Obesity-Induced Dysregulation of Glucose and Lipid Homeostasis

Read more ➡️ doi.org/10.2337/db25-0295

a graphical abstract illustrating natural language processing for automated extraction of CGM data.

NLP accurately extracted data from CGM documents stored in EHRs (99.87% Libre, 100% Dexcom). This enhances the efficiency of reusing CGM data for population-based research to improve diabetes care.

Read more ➡️ doi.org/10.2337/dc25-1595

Cannabis isn’t risk-free for people with diabetes—it’s linked to higher DKA risk and blood sugar swings. Learn more and get tips for talking with your care team in this Diabetes Day by Day episode: https://bit.ly/4455IHL 🎧

A graphical abstract illustrating the beginning score development of the linked study.

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score

Read more ➡️ doi.org/10.2337/db25-0772

A graphical abstract illustrating what's keeping the US from better population health.

To improve population health and reduce health care spending, particularly for diabetes, the U.S. should improve income supports and work towards a public health care purchaser with monopsony power.

Read more ➡️ doi.org/10.2337/dci25-0003

A list of highlights from the linked article

Gut Microbiota–Decanoic Acid–Interleukin-17A Axis Orchestrates Hyperglycemia-Induced Osteoporosis in Male Mice

Read more ➡️ doi.org/10.2337/db25-0471

A graphical abstract illustrating tirzepatide in adults with type 1 diabetes

Tirzepatide Reduces Weight and Insulin Dose and Improves Body Composition in Type 1 Diabetes: A 12-Week, Phase 2 Randomised, Double-Blind, Placebo-Controlled Trial (TIRTLE1)

Read more ➡️ doi.org/10.2337/dc25-2379

A list of highlights from the linked article

Lysyl Oxidase Promotes Actin-Dependent Neutrophil Activation and Cytotoxicity Toward Retinal Endothelial Cells in Diabetes

Read more ➡️ doi.org/10.2337/db25-0541

A man listens to a podcast on his laptop beneath the logo for Diabetes Core Update, featuring the insignia of the American Diabetes Association.

🚨 For December, a brand new ep of #DiabetesCoreUpdate, the #podcast covering the most important articles in #diabetes.

🎧Listen at: https://bit.ly/DOC_Update

Topics this month include:
✨Acute Pancreatitis & Incretin Medications
✨Predicting Heart Failure via Natriuretic Peptide Levels
✨and more!

A graphical abstract illustrating the landscape of adaptive and innovative trials in diabetes.

Adaptive trial designs are reshaping research. In diabetes, only a handful exist — our scoping review highlights barriers and opportunities for broader

Read more ➡️ doi.org/10.2337/dc25-1508

A graphical abstract from the linked article

Flt3L-Derived Antigen-Presenting Cell Transfer in Neonatal NOD Mice Reduces the Incidence of Type 1 Diabetes

Read more ➡️ doi.org/10.2337/db25-0055

A graphic illustration from the linked article

Mendelian randomization and mediation analysis study shows that GLP-1RAs reduce the risk of myocardial infarction mainly via metabolic improvements (HbA1c, BMI, lipids, BP), with no direct effect.

Read more ➡️ doi.org/10.2337/dc25-1822

The cover of the December issue of Diabetes, featuring a conceptual illustration of the pharmacological interplay between GLP-1 and LEAP2.

⭐ 📖 Paper of the Month: Dec.
Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells
Walters et al.
➡️ doi.org/10.2337/db24...

Articles are chosen 🗓️ monthly & 🆓 to read online #paperofthemonth #diabetes

A graphical abstract with two mice showing a decrease in diabetes incidence.

Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice

Read more ➡️ doi.org/10.2337/db25-0324

"Sharing and Caring for Diabetes," acrylic paint on stretched canvas, 2023, Jodie Reynolds. For more information, see The Art of Diabetes Care, p. 1979.

👀 The December 2025 issue of Diabetes Care is here, with the latest research on #diabetes management & care.

🔗 diabetesjournals.org/care/issue/48/12

Featuring:
✨ Hypercortisolism & T2D
✨ Exploratory analysis of the SYNERGY-NASH trial
✨ & more!