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James D Chalmers

@profjdchalmers.bsky.social

Asthma and Lung UK Chair of Respiratory Research, University of Dundee. Bronchiectasis, Respiratory Infection, Science, Clinical research. Chief Editor of the European Respiratory Journal. Tweets in a personal capacity

428 Followers  |  87 Following  |  4 Posts  |  Joined: 18.11.2024  |  2.1661

Latest posts by profjdchalmers.bsky.social on Bluesky

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Our first speaker at the #CPGonLungHealth is @profjdchalmers.bsky.social . He talks about the world leading work that has been led from his team in Dundee. It’s a condition that doesn’t get the focus it needs and it is incredible what has been achieved in the last 14 years @emmaharpermsp.bsky.social

02.05.2025 11:29 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Broad Immunomodulatory Effects of the Dipeptidyl Peptidase-1 Inhibitor Brensocatib in Bronchiectasis: Data from the Phase 2, Double-Blind, Placebo-controlled WILLOW Trial

A novel treatment for bronchiectasis

@profjdchalmers.bsky.social

www.atsjournals.org/doi/full/10....

04.05.2025 21:50 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Thanks to Emma Johnson, MBBS, MSc, PhD, for contributing to the May issue

Broad Immunomodulatory Effects of the DPP1 Inhibitor Brensocatib in Bronchiectasis: Data from the Phase 2, Double-Blind, Placebo-controlled WILLOW Trial

@profjdchalmers.bsky.social

www.atsjournals.org/doi/10.1164/...

04.05.2025 21:59 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Such an honor and a privilege to share the stage with Rene Wyndham, Susanne Vijverberg, Saglani Sejal, @profjdchalmers.bsky.social, Rory Morty, Sara Cuevas OcaΓ±a and @danielchengyuwu.bsky.social for the early-career delegates session of the 2025 edition of the ERS Lung Science Conference #LSC2025.

23.03.2025 07:46 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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European #Bronchiectasis Patient Conference suggestion: bring the checklist to your doctor!!! Am I getting ALL of these recommendations??

15.03.2025 14:15 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

#Bronchiectasis patient conference was excellent today - even kept me in on a rare sunny day in Scotland - but I got out for a walk afterwards

@profjdchalmers.bsky.social

15.03.2025 19:43 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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πŸ”₯ πŸ”₯ πŸ”₯ Hot of the press: Cardiovascular benefits and safety profile of macrolide maintenance therapy in patients with bronchiectasis

buff.ly/CGXv34s

10.03.2025 22:42 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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European #Bronchiectasis Pt Conf Sat, March 15th‼️
Amazing experts participating:
βœ… Dr. James Chalmers (aka Dr. Bronchiectasis!) from Scotland
βœ… Dr. Michal Shteinberg from Israel
βœ… Dr. Pamela McShane from the US
…and other international experts!
tinyurl.com/2r5nh6rh

11.03.2025 17:55 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 2
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🌟Day 2 at #EBROW25: Breaking New Ground!🌟

Exciting updates on new treatments for #bronchiectasis and #NTM infections from Prof. @profjdchalmers.bsky.social from @dundee.ac.uk & Prof. Charles Daley from @nationaljewish.org

πŸ’¬ Insightful, interactive, and inspiring!

22.02.2025 08:43 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

We have so much to learn about the heterogenous disease that is Bronchiectasis! Dr. Thi shared some of the excellent work that is being done around the world, led by @profjdchalmers.bsky.social and colleagues, including therapies to reduce neutrophilic inflammation.

01.03.2025 15:41 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study The clinical characteristics of patients with bronchiectasis in China show differences compared with cohorts in Europe and India. Bronchiectasis is more severe with a higher burden of exacerbations in...

πŸ““We have an #OpenAccess Article reporting on the Baseline characteristics of patients in the Chinese #Bronchiectasis Registry

β€œThe management of patients with bronchiectasis in China urgently needs standardisation and improvement”

www.thelancet.com/journals/lan...

@profjdchalmers.bsky.social

06.02.2025 09:23 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Really enjoyed #RTI2025 & chatting all things 🫁 infection. Many thanks to the organisers for asking me to speak.

Also super proud of Elen Vink for winning the poster prize for her work on the CHARISMA Study. πŸ†πŸ₯³πŸ™Œ

@lenagroup4resp.bsky.social
@profjdchalmers.bsky.social
@dbogaert.bsky.social

05.02.2025 14:45 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Cardiovascular Benefits and Safety Profile of Macrolide Maintenance Therapy in Patients with Bronchiectasis BackgroundMacrolide maintenance therapy (MMT) has demonstrated notable efficacy in reducing exacerbation in patients with bronchiectasis, which is a major risk factor for cardiovascular events. However, a comprehensive assessment of the cardiovascular benefits and safety profile of MMT in this population is lacking.MethodsThis territory-wide cohort study analyzed patients diagnosed with bronchiectasis in Hong Kong between 2001 and 2018. Patients were classified as MMT receivers or macrolide non-receivers based on the administration of MMT. Propensity score (PS) matching was employed for confounding factors adjustment. The primary outcome of interest was major adverse cardiovascular events (MACE), a composite of cardiovascular death, myocardial infarction and stroke. The safety outcome was the occurrence of ventricular arrhythmias or sudden cardiac death. Cox proportional hazard regression analysis was utilized to compare the incidence of outcomes across the two groups.ResultsA total of 22 895 patients with bronchiectasis were identified. Following 1:2 PS matching, the final cohort consisted of 3137 individuals, with 1123 MMT receivers and 2014 macrolide non-receivers. MMT administration was associated with a significant reduced risk of MACE (16.38 versus 24.11 events per 1000 person years; HR 0.68; 95% CI 0.52–0.90). Importantly, the use of MMT was not associated with elevated risk of ventricular arrhythmias or sudden cardiac death (7.17 versus 7.67 events per 1000 person years; HR 0.93; 95% CI 0.60–1.44).ConclusionsThe administration of MMT in patients with bronchiectasis was associated with a significant reduction in the risk of MACE, without any evidence suggesting an increased risk of severe arrhythmia-related adverse events.

πŸ†•οΈβœ¨οΈLarge cohort
Administration of Macrolide maintenance therapy in patients with bronchiectasis was associated with a significant reduction in the risk of MACE, without any evidence suggesting an increased risk of severe arrhythmia-related AEs #idsky
publications.ersnet.org/content/erj/...

13.12.2024 00:29 β€” πŸ‘ 12    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
Welcome! You are invited to join a meeting: Extensive Acute and Sustained Changes to Neutrophil Proteomes Post-SARS-CoV-2 Infection. After registering, you will receive a confirmation email about join... During this journal club, Merete Long, PhD, MSc will present the recently published European Respiratory Journal paper which describes their analysis of peripheral blood neutrophils from hospitalized ...

Upcoming journal club "Extensive Acute and Sustained Changes to Neutrophil Proteomes Post-SARS-CoV-2 Infection" on 14 Jan @ 11amET/2pmPT. Register thoracic.zoom.us/meeting/regi... site.thoracic.org/events/exten... @ats-aii.bsky.social @ats-assemblies.bsky.social @profjdchalmers.bsky.social

03.01.2025 17:06 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Sotatercept approved to treat adult patients with pulmonary arterial hypertension (PAH) The Medicines and Healthcare products Regulatory Agency (MHRA) has approved (27 December 2024) the medicine sotatercept (Winrevair) to treat pulmonary arterial hypertension (PAH).

A nice end to the year for PAH patients in UK. www.gov.uk/government/n...

31.12.2024 19:59 β€” πŸ‘ 12    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Rethinking bronchiectasis as an inflammatory disease - The Lancet Respiratory Medicine

03.12.2024 11:30 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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The Precision Medicine Era of Bronchiectasis

Rethinking #bronchiectasis refers to a shift in understanding BE as primarily a chronic inflammatory disease rather than just an infective disorder. This emphasizes the need for early identification of at-risk individuals & the development of anti-inflammatory treatments.
tinyurl.com/yfn7e5at

24.11.2024 10:16 β€” πŸ‘ 16    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

You are far too kind
Great to see you last week πŸ˜€

11.12.2024 22:52 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Trial in bronchiectasis has been recently announced ! Watch this space

02.12.2024 20:03 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Heading home after a fantastic #BTSWinter2024 Leaving energised and grateful for friends and the opportunity to talk #mesothelioma in the Plenary Scientific Symposium. Also excited for 2025 under our new BTS President!

29.11.2024 18:11 β€” πŸ‘ 15    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Thank you so much to @balrcommunity.bsky.social for the early career researcher award. Very grateful for the opportunity to present at #BTSWinter2024 and thankful to everyone in the Dundee respiratory research group for all your support in this project. @profjdchalmers.bsky.social

29.11.2024 16:21 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Incredibly proud of Emma Johnson @emma_d_johnson
Winner of the 2024 BALR Early Career Investigator Award at British Thoracic Society Winter Meeting 2024

Congratulations Emma πŸ‘πŸ‘#bronchiectasis

27.11.2024 18:04 β€” πŸ‘ 13    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1

BALR chair @karlstaples.bsky.social and committee member Chloe Hughes now chairing this second part of the BTS/BALR joint symposium on interaction between the lung and external factors, at #BTSwinter2024, Windsor 5th floor.

27.11.2024 11:12 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

This is happening now on the 5th floor in Windsor room at #BTSWinter2024! The BTS/ A+L UK/ BALR early career investigator awards are a highlight of this conference.

27.11.2024 14:30 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
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Congratulations to Dr Aaran Singanayagam for the BTS/BALR mid-career lecture award! Don’t miss his talk tomorrow at #BTSWinter2024!

27.11.2024 16:38 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Welcome to BTSwinter2024
Exciting science in London as the respiratory community comes together
#respisbest

27.11.2024 13:34 β€” πŸ‘ 8    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Next up Prof Chris Carlsten talking about pollution/airway microbiome interactions at the BTS/BALR joint symposium a #BTSWinter2024 in Windsor on 5th floor.

27.11.2024 11:44 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Overview | Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN) | Guidance | NICE

New guidelines.
Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN).
www.nice.org.uk/guidance/ng245 #BTSWinter2024 #LungSky #RespEd

27.11.2024 11:06 β€” πŸ‘ 25    πŸ” 9    πŸ’¬ 1    πŸ“Œ 1
Award from the BTS showing a picture of Dr. Aran Singanayagam for his work on "Respiratory viral infections: susceptibility, severity, and sequelae"

Award from the BTS showing a picture of Dr. Aran Singanayagam for his work on "Respiratory viral infections: susceptibility, severity, and sequelae"

Congratulations to @singanayagamlab.bsky.social for this amazing recognition from the BTS for his work on "Respiratory viral infections: susceptibility, severity, and sequelae" ! So well deserved! #pulmsky #lungs #IDsky #midcareer

27.11.2024 13:21 β€” πŸ‘ 21    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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BALR is always proud to support the future of Resp Research. The winners of the BTS/Asthma+Lung UK and BTS/BALR mid-career lecture awards Dr Elaine Soon and Dr Aran Singanayagam will present their work at #BTSwinter2024 on Thurs 28/11 at 4.15pm in the Churchill room.

25.11.2024 15:21 β€” πŸ‘ 7    πŸ” 6    πŸ’¬ 2    πŸ“Œ 0

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