EMBO Molecular Medicine

A fetal oncogene NUAK2 is an emerging therapeutic target in #glioblastoma

By H. Jo, S. Munoz, S. Glasgow & colleagues @ucsandiego.bsky.social

🗞️ doi.org/10.1038/s443...

Online today: Convergent activation of the #IntegratedStressResponse and ER–mitochondria uncoupling in VAPB-associated #AmyotrophicLateralSclerosis

By C. Landry, H. Miranda & colleagues at Case Western Reserve University

➡️ doi.org/10.1038/s443...

Check this nice Resource by B. Hunter, J. O’Sullivan, J. Yang, S. Lal & colleagues at University of Sidney 👉 doi.org/10.1038/s443...

"Left ventricular myocardial molecular profile of human diabetic #IschaemicCardiomyopathy"

📣Don’t miss this review on the current treatment framework in #ProstateCancer & novel approaches and targets that are set to transform clinical care => doi.org/10.1038/s443...

by S. Nouruzi, A. Zoubeidi and colleagues at Vancouver Prostate Centre

Predicting and Responding to Emerging Viral Infections | Keystone Symposia Join us at the Keystone Symposia on Predicting and Responding to Emerging Viral Infections, October 2025, in Geneva, with field leaders!

Deadlines are approaching for @keystonesymposia.bsky.social Predicting & Responding to Emerging #Virus Infections, this October in Geneva! Our @embomolmed.org editor Zeljko Durdevic will attend.

Poster abstract and registration dates => keysym.us/KSEmergingVirus26 #KSEmergingVirus26

Also online today 👉 Perspective by V. Katanaev and G. Solis at University of Geneva on #GaMutations associated with rare diseases

🗞️ doi.org/10.1038/s443...

Read this Perspective by L Martin, G Gabbiani & GRY De Meyer at University of Antwerp on the role of #SMAD7 in cardiac, skeletal muscle, and vascular tissues.

🗞️ doi.org/10.1038/s443...

De novo pyrimidine synthesis is a collateral #MetabolicVulnerability in NF2-deficient #mesothelioma 👉 doi.org/10.1038/s443...

By D Xu, Y Gao, RW Peng, Y Shu et al. at University of Bern

Read also N&V by J Jia & G Stathopoulos @ucy1.bsky.social @www.helmholtz-munich.de 👉 doi.org/10.1038/s443...

Online today! MicroRNA-33 inhibition ameliorates muscular #Dystrophy by enhancing #SkeletalMuscle regeneration 👉 doi.org/10.1038/s443...

By N. Sowa, T. Horie, K. Ono & colleagues at Kyoto University

Read also related N&V by M. Lopez & M. Alexander:
🗞️ doi.org/10.1038/s443...

JAK/STAT inhibition protects #GlucocorticoidReceptor knockout mice from lethal #malaria -induced hypoglycemia and hyperinflammation

By F. Prenen, L. Vandermosten, P. Van den Stehen & colleagues at Rega Institute for Medical Research KU Leuven

➡️ doi.org/10.1038/s443...

Online today! #PV1: a novel molecular #PrognosticMarker of distant metastases in various #SolidTumors

By C. Pozzi, R. Sarti, @mrescigno.bsky.social‬ & colleagues at Humanitas Research Hospital

👉 doi.org/10.1038/s443...

#Peptidomic analysis of #CSF reveals new biomarker candidates for #AmyotrophicLateralSclerosis

By B. Muqaku, P. Oeckl & colleagues at University Hospital Ulm & @dzne.science

🗞️ doi.org/10.1038/s443...

New study that identifies a novel immunohistochemical staining-based method for identifying #HNSCC patients who would benefit from surgery alone ➡️ doi.org/10.1038/s443...

By X Qiao, J Routila, J Westermarck, S Ventelä & colleagues @utu.fi

Cold exposure promotes the progression of #osteoarthritis through downregulating #APOE in cartilage

By Y Zhang, M Fu, C Zhou, S An, X Wang, Z Wang & colleagues

➡️ doi.org/10.1038/s443...

SFX-01 is therapeutic against #MyeloproliferativeDisorders caused by activating mutations in #Shp2

By HJ Cho, J Smith, C Switzer, P. Eaton and colleagues @qmul.bsky.social

🗞️ doi.org/10.1038/s443...

Read this Perspective by S. Schmidt, X. Qiao and M. Bergö @ki.se‬ that highlights the intricate functions of #antioxidants in #cancer progression, and explore their potential clinical implications ➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine: Vol 17, No 7 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our July issue is online 👉 www.embopress.org/toc/17574684...

The cover highlights the article by M Robert, C Swale, MP Brenier-Pinchart, @hakimi.bsky.social‬ & al. that identifies BSM & BCLA as #biomarkers for chronic #ToxoplasmaGondii infection

Scientific image by @hakimi.bsky.social @inserm.fr

Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan | EMBO Molecular Medicine imageimageThis study reveals that partial chemical reprogramming with defined small-molecule cocktails rejuvenates aged human cells and significantly extends lifespan and healthspan in C. elegans, off...

💡 Publiés récemment dans @embomolmed.org et réalisés @unil.bsky.social ces travaux démontrent qu'un cocktail de seulement deux molécules peut contrer le vieillissement cellulaire, dans des cellules humaines et chez un vers microscopique.
🔗 www.embopress.org/doi/full/10....

@embopress.org @embo.org

🎉Congratulations Judit Jiminez Sainz at Medical University of South Carolina for winning the EMBO Mol. Med. poster award at the #DDRCT25 Fusion conference!

#DNArepair #BRCA

A novel modulator of #IL6R prevents inflammation-induced #PretermBirth and improves newborn outcome.

By F. Côté, S. Chemtob & colleagues ‪@umontreal-en.bsky.social

➡️ doi.org/10.1038/s443...

New study by L. Schoenfeldt, P. Paine, S. Picó, K. Perez, A. Ocampo & colleagues at University of Lausanne shows that partial chemical reprogramming with small-molecule cocktails rejuvenates aged #HumanCells and extends #lifespan and healthspan in #Celegans

➡️ doi.org/10.1038/s443...

Online today! Loss of p300 in proximal tubular cells reduces #RenalFibrosis and endothelial-mesenchymal transition.

By Hyunsik Kim, Beom Seok Kim, Beom Jin Lim, Ho-Geun Yoon & colleagues at Yonsei University College of Medicine Seoul

🗞️ doi.org/10.1038/s443...

Online today! Replicated blood-based #biomarkers for #MyalgicEncephalomyelitis not explicable by inactivity

By S.V. Beentjes, @avakhamseh.bsky.social‬, @cgatist.bsky.social‬ & colleagues @edinburgh-uni.bsky.social

🗞️ doi.org/10.1038/s443...

Ki-67 promotes inflammatory signaling governing #neutrophil recruitment during #RespiratoryInfections ➡️ doi.org/10.1038/s443...

By M. Yee, M. O’Reilly & colleagues @urochester.bsky.social

Small molecule disruption of RARα/NCoR1 interaction inhibits #ChaperoneMediatedAutophagy in #LungCancer

By M. McCabe, A.M. Cuervo, E. Gavathiotis & colleagues @einsteinmededu.bsky.social

➡️ doi.org/10.1038/s443...

Novel Treatment Strategy for Non-Small Cell Lung Cancer

In a new study published in embomolmed.org, Evripidis Gavathiotis, Ph.D., and Ana Maria Cuervo, M.D., Ph.D., have identified the NCoR1/RARα protein complex as a regulator of CMA in #lungcancer. The work opens the door for targeted CMA inhibition across a range of cancers.

#MedSky #autophagy

#Reelin -LRP8 signaling mediates brain dissemination of breast #CancerCells via abluminal migration.

#zebrafish

By H. Huang, M. Zhang, E. Huang, G. Ning, J. Zhang & colleagues at Hospital of Guangdong Medical University

🗞️ doi.org/10.1038/s443...

📣Read this new review by M. Shinohara & colleagues @dukemedschool.bsky.social on the interplay between #FungalInfections and #autoimmunity ➡️
doi.org/10.1038/s443...

Our June issue is online! www.embopress.org/toc/17574684...

The beautiful cover highlights the article by @maria-sibilia.bsky.social & al. on the tumor-intrinsic role of #EGFR in #KRAS mutant #ColorectalCancer 👉 doi.org/10.1038/s443...

Scientific image: D. Kirchhofer, D. Krauß & M. Sibilia

Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1 @embomolmed.org
www.embopress.org/doi/full/10....