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PaquetLab

@paquetlab.bsky.social

3D iPSC models and CRISPR to investigate mechanisms of neurodegenerative and neurovascular disorders | Professor of Neurobiology at LMU Munich | https://isd-research.de/paquetlab

393 Followers  |  124 Following  |  45 Posts  |  Joined: 29.12.2024  |  2.0819

Latest posts by paquetlab.bsky.social on Bluesky

Big congrats to Mila @milaborri.bsky.social from the lab for obtaining a EU-funded #MCSA postdoc fellowship!! We look forward to working with you on developing #iPSC based vascularized human brain tissue models to study major #brain diseases, such as #Alzheimer's and #stroke!

09.10.2025 06:57 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Great conference! Very happy to join again.οΏΌ

03.10.2025 06:33 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Very happy to be at the Barcelona #B4event blood-brain-barrier meeting and present our work this afternoon on a novel fully #iPSC based model of the #BBB that allows investigating neurovascular diseases! premc.org/blood-brain-...

01.10.2025 13:50 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

What makes Bluesky different: it’s open source, so anyone can contribute to building the experience they want. And even if you build a whole new app, the protocol means you can migrate with your data, identity, and relationships intact.

17.09.2025 18:10 β€” πŸ‘ 3475    πŸ” 299    πŸ’¬ 149    πŸ“Œ 49

Great #BBB Model to study malaria! Congrats Maria and Team!

07.08.2025 13:13 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Primary paper: www.cell.com/cell-reports...

29.07.2025 15:00 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
The LMU Germany Scholarship holders for 2025

The LMU Germany Scholarship holders for 2025

πŸŽ“πŸ‡©πŸ‡ͺ Over 500 LMU students will get the Germany Scholarship in 2025 – a record! πŸ’‘ It provides €300/month, funded half by the government, half by private sponsors. Supporting talent and social engagement, no matter their background. #LMU #Scholarship #Education πŸ‘‰ Read more: www.lmu.de/en/newsroom/....

16.07.2025 09:30 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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'Stem Cells in Neuroscience' is returning to TΓΌbingen, Germany.

SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com

Please share
#stemcelltuebingen2026

@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social

01.07.2025 07:07 β€” πŸ‘ 7    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
Map of Germany with the Clusters of Excellence

Map of Germany with the Clusters of Excellence

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

22.05.2025 18:10 β€” πŸ‘ 116    πŸ” 45    πŸ’¬ 2    πŸ“Œ 7
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πŸŽ‰ Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! πŸŽ‰ #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...

22.05.2025 16:24 β€” πŸ‘ 36    πŸ” 11    πŸ’¬ 1    πŸ“Œ 4

…and our research cluster @synergy-munich.bsky.social is one of the funded ones! Big congratulations to all involved!

22.05.2025 15:32 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Important engagement by our Master student Stella:

07.05.2025 18:37 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

β†’ europa.eu/!TTbWbJ

05.05.2025 10:00 β€” πŸ‘ 4089    πŸ” 983    πŸ’¬ 124    πŸ“Œ 139

Excited to be at #Tau2025 in London! I really enjoy the great and inspiring discussions with all the fellow Tau enthusiasts! πŸ”¬πŸ‘©β€πŸ”¬

24.04.2025 15:23 β€” πŸ‘ 11    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

24.04.2025 15:11 β€” πŸ‘ 10    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1

Great starter pack for Tau aficionados! Thanks Melissa

24.04.2025 15:08 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

https://sciencebusiness.net/r-d-funding/european-research-council/erc-double-allowance-researchers-moving-eu

19.04.2025 05:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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πŸš€ New study reveals how four different anti-amyloid drugs interact with amyloid beta protein. They found that lecanemab performed best in binding to small oligomeric forms of the amyloid protein, suggesting a working model for treating people in the earlier stages of Alzheimer’s (1/4)

18.04.2025 10:01 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." πŸ‘πŸ‘πŸ‘
www.sciencedirect.com/science/arti...

14.04.2025 18:54 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

Losing sleep over #iPSC transgene silencing after differentiation?
Same here β€” too many times😭

So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.

Our #preprint is outπŸ‘‡
πŸ”— www.biorxiv.org/content/10.1...

Supported by @cziscience.bsky.social

15.04.2025 15:37 β€” πŸ‘ 33    πŸ” 13    πŸ’¬ 1    πŸ“Œ 1
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Clinical trials test the safety of stem-cell therapy for Parkinson’s disease Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its ...

It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...

16.04.2025 15:35 β€” πŸ‘ 476    πŸ” 107    πŸ’¬ 5    πŸ“Œ 13

Very nice event! Thanks for organizing..

09.04.2025 17:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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We are excited to announce Prof Malin Parmar, Ph.D. as our next webinar speaker!

Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease

April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3

09.04.2025 14:12 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 2

Welcome @ismnd.bsky.social to #Bluesky!

09.04.2025 14:20 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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International scientists rethink U.S. conference attendance Opposition to Trump administration and fears of customs run-ins are shifting travel plans

The telling is not only that scientists are avoiding trips to the πŸ‡ΊπŸ‡Έ It is the fact that most interviewed for this piece asked to remain anonymous with (very real) fear of retaliation. by @klangin.bsky.social www.science.org/content/arti...

31.03.2025 22:24 β€” πŸ‘ 22    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1
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If you are at #ADPD2025 in Vienna, please join us now in hall F1 to get an update about our human 3D #iPSC model of #Alzheimer disease!

02.04.2025 14:36 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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St. Louis study shows that drug may prevent Alzheimer’s. NIH slowdowns threaten future research Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

20.03.2025 11:45 β€” πŸ‘ 17    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1
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Great talks and discussions at the 🧠 #SCMND meeting in Edinburgh this week, where @julien-klimmt.bsky.social from our lab presented our #ipsc 3D brain tissue model for #Alzheimer’s diseases to a full audience

29.03.2025 06:59 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Great work, congrats Nico and team! οΏΌ

18.03.2025 11:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Many thanks to @afi-ev.bsky.social‬ and their generous donors for supporting our work!!! Vielen Dank an AFI und ihre großzΓΌgigen Spender fΓΌr die UnterstΓΌtzung unserer Arbeit!!!

12.03.2025 16:48 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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