PaquetLab

Primary paper: www.cell.com/cell-reports...

The LMU Germany Scholarship holders for 2025

🎓🇩🇪 Over 500 LMU students will get the Germany Scholarship in 2025 – a record! 💡 It provides €300/month, funded half by the government, half by private sponsors. Supporting talent and social engagement, no matter their background. #LMU #Scholarship #Education 👉 Read more: www.lmu.de/en/newsroom/....

'Stem Cells in Neuroscience' is returning to Tübingen, Germany.

SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com

Please share
#stemcelltuebingen2026

@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social

Map of Germany with the Clusters of Excellence

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...

…and our research cluster @synergy-munich.bsky.social is one of the funded ones! Big congratulations to all involved!

Important engagement by our Master student Stella:

Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

→ europa.eu/!TTbWbJ

Excited to be at #Tau2025 in London! I really enjoy the great and inspiring discussions with all the fellow Tau enthusiasts! 🔬👩‍🔬

Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

Great starter pack for Tau aficionados! Thanks Melissa

https://sciencebusiness.net/r-d-funding/european-research-council/erc-double-allowance-researchers-moving-eu

🚀 New study reveals how four different anti-amyloid drugs interact with amyloid beta protein. They found that lecanemab performed best in binding to small oligomeric forms of the amyloid protein, suggesting a working model for treating people in the earlier stages of Alzheimer’s (1/4)

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...

Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭

So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.

Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...

Supported by @cziscience.bsky.social

Clinical trials test the safety of stem-cell therapy for Parkinson’s disease Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its ...

It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...

Very nice event! Thanks for organizing..

We are excited to announce Prof Malin Parmar, Ph.D. as our next webinar speaker!

Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease

April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3

Welcome @ismnd.bsky.social to #Bluesky!

International scientists rethink U.S. conference attendance Opposition to Trump administration and fears of customs run-ins are shifting travel plans

The telling is not only that scientists are avoiding trips to the 🇺🇸 It is the fact that most interviewed for this piece asked to remain anonymous with (very real) fear of retaliation. by @klangin.bsky.social www.science.org/content/arti...

If you are at #ADPD2025 in Vienna, please join us now in hall F1 to get an update about our human 3D #iPSC model of #Alzheimer disease!

St. Louis study shows that drug may prevent Alzheimer’s. NIH slowdowns threaten future research Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

Washington University-led research shows a small group of participants in an Alzheimer’s study experienced a significant delay in the onset of symptoms.

Great talks and discussions at the 🧠 #SCMND meeting in Edinburgh this week, where @julien-klimmt.bsky.social from our lab presented our #ipsc 3D brain tissue model for #Alzheimer’s diseases to a full audience

Great work, congrats Nico and team! 

Many thanks to @afi-ev.bsky.social‬ and their generous donors for supporting our work!!! Vielen Dank an AFI und ihre großzügigen Spender für die Unterstützung unserer Arbeit!!!

The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment. We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network. We are looking for a highly motivated individual with the following skills: -extensive international scientific working experience in vascular biology or a closely related research field (required) -experience in molecular biology, biochemistry and/or omics techniques; cell culture experience is a plus -excellent English skills in speaking, writing about and presenting scientific data -interest in working in collaborative network of friendly scientists around the world A start date soon in 2025 is desired. Join us! dominik.paquet@med.uni-muenchen.de www.isd-research.de/paquetlab www.brenda-leducq.de

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

Did you know?🧐
🗺️The campuses Grosshadern and Martinsried together form a hotspot of life science research. Located at the♥️, @genecenter-lmu.bsky.social is part of a vibrant research community
@lmumuenchen.bsky.social @lmu-klinikum.bsky.social @mpibiochem.bsky.social @bmc-lmu.bsky.social

Great lineup of speakers at #SCMND2025 and our own ECR @julien-klimmt.bsky.social is one of them 😀 looking forward!

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

'We at Nature denounce this assault on science. And we encourage the global research community, wherever they can, to voice their opposition' doi.org/10.1038/d415...
@nature.com

We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM