BASE mRNA Facility

🔬 Ever wondered what mRNA-LNPs look like?

Thanks to the Wolfram Group, we have this stunning image of BASE-produced eGFP mRNA encapsulated in LNPs!

We’re proud to support researchers with high-quality #mRNA and #LNP, helping drive innovation from the lab to real-world applications.

We are looking for a Software Engineer who will lead the development of software platform for the design of #mRNA medicines. The role will include developing, implementing, and maintaining mRNA design software to industry standards.
www.linkedin.com/jobs/view/41...

We look forward to working with the Vaxxas team to deliver #mRNA vaccines using the microarray patch!

Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR Human NK cells can be efficiently transfected with mRNA to safely express an EphA2-CAR without genomic alterations. EphA2-targeted CAR-NK cells exhibit enhanced cytotoxicity against paediatric sarco...

#mRNA meets cell therapies! It was great to collaborate with Fernando Guimaraes's team to develop mRNA CARs and delivered them to NK cells. NKs transfected with EphA2 CAR mRNA elicited a strong anti-tumour response in animal sarcoma models.

onlinelibrary.wiley.com/doi/10.1002/...

We’re excited to announce that we’re back in action and ready to help you achieve your #mRNA goals in 2025. Our team is re-energised and eager to continue providing the reliable, high-quality mRNA solutions.

Reach out to us to discuss your project need! 🧬
✉️ base@uq.edu.au

YouTube video by TEDx Talks How personalized mRNA vaccines could revolutionize cancer treatment | Seth Cheetham | TEDxUQ

Earlier this year I had the opportunity to present a TEDx talk on the transformative potential of personalised #mRNA vaccines for cancer. The recording is out now:

www.youtube.com/watch?v=BnSO...

#RNAsky #RNAtx @basemrna.bsky.social

BASE team took some time to celebrate the progress we’ve achieved this year. 🎄 From a delicious team lunch to an epic round of laser tag! 💥🔫 it was a fantastic way to bond, recharge, and have fun.

A huge shoutout to our amazing team—your hard work and dedication make all the difference.

mRNArchitect: optimized design of mRNA sequences Summary: mRNA design is the critical first step in the development of a new vaccine or therapy. The mRNA primary sequence is assembled from multiple elements, including the coding sequence of the targ...

There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @basemrna.bsky.social software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs.

www.biorxiv.org/content/10.1...

Simply input your coding sequence of interest, and mRNArchitect will provide multiple candidate mRNA sequences, each accompanied by comprehensive statistics for evaluation.

At BASE, we have successfully used mRNArchitect to design hundreds of mRNAs for diverse applications. 🧬

We are excited to introduce #mRNArchitect - a software toolkit for designing and optimising mRNA sequences.

basefacility.org.au/software/

This freely available software enables users to generate mRNA candidates optimised for expression, stability& immunogenicity.

I made a starter pack for interesting people in the mRNA vaccines and therapeutics space. Message me if you want to be added. #RNAsky

go.bsky.app/VSHfBce

We are #hiring!

We're looking for an mRNA Production Scientist, a Software Developer, and a Bioinformatician.

Join our mRNA Production and mRNA Design teams as we push the boundaries of mRNA innovation! 🧬
www.linkedin.com/posts/base-f...

VAXXED: Game on, with BASE and WEHI Podcast Episode · Phase III · 19/11/2024 · 26m

We're building Australia's first centre for the designing and manufacturing personalised cancer vaccines at the BASE mRNA facility. On the PhaseIII podcast I discuss the transformative potential of mRNA for cancer and our efforts to bring this tech to patients.

podcasts.apple.com/au/podcast/v...