Mitro Miihkinen's Avatar

Mitro Miihkinen

@mitroe.bsky.social

Computational drug development dude // University of Helsinki, Institute for Molecular Medicine Finland (FIMM)

143 Followers  |  606 Following  |  11 Posts  |  Joined: 13.11.2024  |  1.9883

Latest posts by mitroe.bsky.social on Bluesky

Pre-print alert: defining colon fibroblast species by their location and the genes they express, in health and in cancer: www.biorxiv.org/content/10.1...

05.08.2025 07:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

10.06.2025 05:32 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI

09.06.2025 19:18 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 3    πŸ“Œ 0

These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.

04.06.2025 20:20 β€” πŸ‘ 102    πŸ” 48    πŸ’¬ 2    πŸ“Œ 1
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Estimating the completeness of large-scale single-cell sequencing projects During embryonic development, cells undergo differentiation into highly specialized cell types. Capitalizing on single-cell RNA sequencing, many initiatives and substantial resources have been establi...

How complete are the current single-cell profiling efforts? Happy to share our updated manuscript now online in www.biorxiv.org/content/10.1...

04.06.2025 14:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Now online in Cancer Discovery: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education - by Rosa Trotta, Silvia Rivis, Shikang Zhao, Massimiliano Mazzone and colleagues doi.org/10.1158/2159...

07.04.2025 14:23 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

This is catastrophic for pancreatic cancer patients

26.03.2025 12:11 β€” πŸ‘ 147    πŸ” 79    πŸ’¬ 4    πŸ“Œ 6
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We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
πŸ“Έ @oonapaavolainen.bsky.social

20.03.2025 14:04 β€” πŸ‘ 19    πŸ” 19    πŸ’¬ 2    πŸ“Œ 1

Always a humbling experience πŸ˜€πŸ‘

18.03.2025 11:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Calling all researchers interested in drug repurposing!πŸ”¬πŸ’Š

A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!πŸŽ‰πŸ“„

πŸ“–Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM

18.03.2025 10:03 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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remedi4all.bsky.social The European Platform for Medicines Repurposing. Funded by #HorizonEurope. remedi4all.org

remedi4all.bsky.social

18.03.2025 10:46 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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How to find new uses for existing drugs? Our massive review on computational drug repurposing is now online on Nature Reviews Drug Discovery. Team effort from the REMEDi4ALL consortium. doi.org/10.1038/s415...

18.03.2025 10:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Spatial profiling of ANO7 in prostate tissue: links to AR‐signalling‐associated lipid metabolism and inflammation Prostate cancer (PrCa) is highly prevalent in the Western world. Currently, however, there are many unmet needs in PrCa care, for example in distinguishing between clinically significant and indolent...

pathsocjournals.onlinelibrary.wiley.com/doi/epdf/10....

18.03.2025 10:15 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
https://pathsocjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/path.6405

https://pathsocjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/path.6405

Spatial transcriptomics study of the human prostate: ANO7 (PrCa risk gene) shows a switch-like on/off expression patterns in adjacent epithelia, which differ in the amount of NK cell infiltration and lipid metabolism among other things. Super interesting and fun collaboration

18.03.2025 10:14 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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So excited that our study made the cover of Nature Genetics this month!

17.03.2025 15:20 β€” πŸ‘ 66    πŸ” 10    πŸ’¬ 4    πŸ“Œ 2

#KeyboardAesthetics

06.03.2025 12:47 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Yes! We started thinking tissues as ecological communities consisting of cells and it is fun: www.biorxiv.org/content/10.1...

06.03.2025 12:40 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Collage of immunostaining microscopy pictures of #Drosophila ovarioles.

Collage of immunostaining microscopy pictures of #Drosophila ovarioles.

Today's #microscopy session inspired me to do some art. These ovarioles look like trees, don't you think? If you want to learn what made them this way, stay tuned for our #SingleCell analysis of these - preprint coming soon!

04.03.2025 15:05 β€” πŸ‘ 18    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

🧬 Are single-cell atlases complete? This was an interesting one to do: www.biorxiv.org/content/10.1... #scRNAseq #single-cell #atlas #cell #biodiversity #biostatistics

05.03.2025 13:35 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
AI@HHMI teaser saying "AI@HHMI | Accelerating Innovation in Biology". The backdrop is an artistic rendering of the compute graph of a network architecture for semantic image segmentation that I think looks really cute.

AI@HHMI teaser saying "AI@HHMI | Accelerating Innovation in Biology". The backdrop is an artistic rendering of the compute graph of a network architecture for semantic image segmentation that I think looks really cute.

We are looking for exceptional #AIScientist|s to join our #AI@HHMI initiative at #HHMIJanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design.

ai.hhmi.org#join-our-team

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15.11.2024 14:13 β€” πŸ‘ 52    πŸ” 33    πŸ’¬ 1    πŸ“Œ 1
Recruitment Recruitment is now open! Apply for one of the 16 positions availablein the Adaptmet network and build your futureas a researcher in metastasis! Adaptmet is offering generous three-year fellowship...

16 funded PhD positions for 2025 in metastatic studies adaptmet.eu/recruitment/

18.11.2024 13:26 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@mitroe is following 20 prominent accounts