Hi! We find that replacement of endogenous integrin beta1 with a non-phosphorylatable mutant, reduces cancer invasion, and this was phenocopied by Shp2 inhibition in WT expressing cells (not in the mutant cells). It may be that Src & paxillin phosphorylation is also reduced in the mutant cells.
28.05.2025 03:41 — 👍 0 🔁 0 💬 0 📌 0
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
26.05.2025 10:29 — 👍 29 🔁 15 💬 1 📌 0
Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025
12.02.2025 21:14 — 👍 3 🔁 1 💬 0 📌 0
🎯Building EU Networks of Expertise on Cancer
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Post Doc in the Microenvironments for Medicine Group @ IBEC 🇪🇸 in collaboration with the Mechanobiology & Biomaterials Group @ UMONS 🇧🇪
Research Programme Manager for Cancer Research UK. Building diverse and impactful discovery science communities.
Biochemist of 20y. Big fan of trees and wild spaces. Serial hobbyist: Theatre Tech / Climber / Caver / Softballer. ProEU. Opinions mine.
Scientist studying epithelial biology, stem cells and cancer at UCL (@epicentr.bsky.social) 🫁
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Researcher working on integrin traffic and cancer biology @ Turku Centre for Biotechnology, University of Turku. All opinions are my own
Computational drug development dude //
University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
Group leader in breast development and cancer @utu.fi. Curious and fun-loving. Mother of one. #PeuhuLab
HHMI’s Janelia Research Campus in Ashburn, Virginia, is innovating research practices and technologies to solve biology’s deepest mysteries. https://www.janelia.org/
The Victorian Comprehensive Cancer Centre Alliance in Melbourne, Australia is a collective of 10 major hospitals, research and academic institutions working together to overcome cancer.
Our lab aim is to grasp the molecular mechanisms by which cells adhere to and move through the body environment in cancer, vascular and rare genetic diseases.
https://www.dep-oncology.unito.it/do/docenti.pl/Show?_id=gserini#tab-profilo
Matrix biology, cell-matrix research at the University of Manchester. Personal tweets. http://www.wellcome-matrix.org/
Peter MacCallum Cancer Centre – or Peter Mac – is a globally-connected leader in cancer treatment, care, research and education. Now in its 75th year of providing specialist cancer care for the Australian community.
🔬 We research and develop treatments for cancer, diseases of development and ageing, immune disorders and infections.
https://www.wehi.edu.au
MSCA/UKRI Fellow studying B cells at @Tolarlab.bsky.social (@iit_ucl) | PhD (she/her) 🇪🇸 🇫🇮 🇬🇧 | Immunology & Cell Biology | Seeing is believing 🔬Typos are my own.
Postdoc in the @etiennemanneville.bsky.social lab @pasteur.fr 🇫🇷🔬 | Previously @ivaskalab.bsky.social 🇫🇮 | Cell migration, mechanobiology, cancer
Image analysis | Infrastructure | Education | Post-doctoral researcher
