Assistant Professor/Associate Professor, Oral Biology
The University at Buffalo School of Dental Medicine (SDM) invites applications from qualified early- to mid-career oral health scientists and/or clinician-scientists for a full-time tenure track acade...
❗️❗️❗️👄👄 #MOUTH 👄👄 🦷🦷 #TEETH 🦷🦷 💧💧 #SALIVA 💧💧🦠🦠 #MICROBIOME🦠🦠 🍭🍭 #glycotime 🍭🍭 ❗️❗️❗️
❗️We are hiring❗️Check out this full-time tenure track academic faculty position in the #UBSDM's Department of Oral Biology.
ms.spr.ly/6045sKrT9
03.08.2025 20:14 — 👍 2 🔁 3 💬 0 📌 0
GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
02.05.2025 08:52 — 👍 21 🔁 11 💬 8 📌 1
Protein engineering strategies to develop lectins by design
Abstract. Glycans regulate a wide array of biological processes, making them central to studies of cell biology. Thus, it is essential to characterize the
Happy to share 3rd paper in a series on glycoT engineering. Prior work in Small (pubmed.ncbi.nlm.nih.gov/40417887) & Nature Commun. (pubmed.ncbi.nlm.nih.gov/40681527/), and most recent in Glycobiology: "Protein engineering strategies to develop lectins by design": academic.oup.com/glycob/artic...
24.07.2025 05:14 — 👍 1 🔁 0 💬 0 📌 0
Mammalian Cell Surface Display for High‐Throughput Protein Engineering of Glycosyltransferases
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Sharing link to our paper on high throughput engineering of glycosyltransferases— you can use it to study structure-function relations, discover disease associated mutations, make super enzymes with unique properties etc.: onlinelibrary.wiley.com/share/VGWXBG...
09.07.2025 14:37 — 👍 0 🔁 0 💬 0 📌 0
Transformer-based Deep Learning for Glycan Structure Inference from Tandem Mass Spectrometry
Glycans play critical roles in diverse biological processes, but their structural analysis by tandem mass spectrometry (MS/MS) remains a major challenge due to their branched structure and stereochemistry. Traditional computational methods, such as database searching, are constrained by the scope of existing libraries and can be computationally intensive. While recent deep learning models have advanced the field, they often struggle to capture the complex, long-range dependencies within MS/MS spectra required for accurate inference. To address these challenges, we present GlycoBERT and GlycoBART, novel transformer-based models for glycan structure prediction from MS/MS data. GlycoBERT, a sequence classifier, achieves 95.1% structural accuracy on test data, surpassing the current state-of-the-art deep learning model, CandyCrunch. However, classification-based methods are inherently limited to predicting structures present in the training data. To overcome this, we developed GlycoBART, a generative sequence-to-sequence model capable of de novo glycan inference. On independent validation datasets, both models demonstrate robust performance. Critically, when applied to an MS/MS dataset from human embryonic kidney cells, GlycoBART generated two de novo glycan structures absent from the training set, one of which is a novel structure not catalogued in major glycan databases. Together, GlycoBERT and GlycoBART establish a new benchmark for glycan analysis, offering a powerful framework that enables more accurate and comprehensive exploration of glycan diversity and discovery. ### Competing Interest Statement The authors have declared no competing interest. National Heart Lung and Blood Institute, https://ror.org/012pb6c26, HL103411
Link to our collaboration with Rudi Gunawan on using deep learning for glycomics: www.biorxiv.org/content/10.1...
08.07.2025 03:18 — 👍 2 🔁 1 💬 0 📌 0
FEBS Press
The H antigen (O blood group), the precursor to A and B blood groups, is expressed on human erythrocytes. Two novel monoclonal antibodies generated using sea lamprey immunization, Tn4-31L and OmcFL3-...
📢New article alert! 'Blood group O expression in normal tissues and tumors', just published in FEBS Journal, highlights findings using our lamprey-derived monoclonal antibodies towards specific H antigen epitopes.
Read at: febs.onlinelibrary.wiley.com/doi/10.1111/...
#glycotime #glycans #bloodgroups
07.07.2025 23:59 — 👍 5 🔁 2 💬 0 📌 0
Creating a modern Windows BlueSky app:
https://apps.microsoft.com/detail/9np22dtfscts?hl=en-us&gl=US
Repo: https://github.com/FireCubeStudios/DarkSky
Discord: https://discord.gg/windows-apps-hub-714581497222398064
Twitter: https://x.com/FireCubeStudios
Medicinal chemist interested in cancer and infectious disease (Fimbrion and WashU). Kinase, protease, GPCR, PDE and lectin inhibitor drug discovery. Antibacterial, antiviral, anthelmintic, anti-parasitic. Small molecule, peptide and carbohydrate.
A charitable foundation supporting the communication and dissemination of information in #chemistry and related disciplines.
We support #OpenScience projects – #DiamondOA publishing, standards, events, cheminformatics
https://www.beilstein-institut.de/en
Microbes & mucus 🤩 | Gut Microbial Ecology | Wageningen University, NL
Professor in Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
Proteins | Sugars | Yeast | Beer | Mass Spectrometry | Professor in Biochemistry UQ. CW chickens, fungi, cats, pups.
Project leader & Head - (Glyco)Proteomics at Max Planck Unit for the Science of Pathogens (MPUSP)
Associate Professor interested in molecular glycobiology, glycomics of lower eukaryotes, glycan arrays, chemical glycobiology, classical music. Viva la libertà!
#mom #humanist #NIH #reentrysci #ally #immigrant
AssocProf @BMERutgers @RutgersCancer @RutgersCS #platelets #translational #omics
previously12yrs @StanfordMed
Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at https://GlycoShape.org, Salem's butler, fucose fanatic #glycotime everyday! She/Her
Scientist, Glycobiologist, Mentor when possible
PhD Candidate with Jim Paulson at Scripps Research | Building immune therapies aimed at cancer’s sweet spot 🍭 #glycotime | Dabbling in protein degraders #TPD 🎯
Director of Protea Glycosciences
Accelerating glycoscience research
The only pan-Canadian research network focusing on leveraging #glycomics and #glycoscience to drive tangible health innovations. #glycotime
Website: glyconet.ca
Molecular Biologist, Scientific researcher. Head of Enzymes for Agroindustrial Bioprocesses Lab (EAB) at IABIMO, INTA 🇦🇷 Our group studies microbial carbohydrate active enzymes that act on plant cell wall polysaccharides.
CERC in Glycomics, Director of Glycomics Institute of Alberta(www.glyco-alberta.ca), Professor of Chemistry, Univ. of Alberta. Work on #glycotime with lectin microarrays and discovering new aspects of #miRNA. Opinions are mine (she/her). www.glycocode.org
Postdoc @VIBLifeSciences, @UGent, and @JNJInnovMedEMEA in the @CompOmics group. Interested in Metabolomics, Proteomics, and ML.
Assistant Professor of Chemical Engineering at @UBuffalo. Research group website: https://shiresearchgroup.github.io/
