Kari Hoffman

Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic Prospects

Our preprint about Neuroinflammation in #LongCovid is online! This group met during the community-driven event #UnitedtoFight last year. This publication in #NeuroCovid is just another example of how science works better when we listen to the community and work together with them! (1/3)

i love it!

Since this is going around again, figured I'd add the more hopeful addendum that encourages scientists to keep doing their important research and to speak out about the current attacks on US science.

rdcu.be/emD0Z

🚨New in @cellpress.bsky.social
We discovered that hippocampal replays in natural-scale environments are highly fragmented, not full-length.
doi.org/10.1016/j.ce...
👇🧵

I just signed the Bethesda Declaration and urge you to do the same today, so that we all stand with NIH researchers as Battacharya appears before the Senate Appropriations Committee tomorrow.

Signed. Read and spread:

Trump’s new ‘gold standard’ rule will destroy American science as we know it | Colette Delawalla The new executive order allows political appointees to undermine research they oppose, paving the way to state-controlled science

New Op-Ed in the Guardian regarding the new "Gold Standard Science" Executive Order.

From @cdelawalla.bsky.social @carlbergstrom.com @briannosek.bsky.social @michaelemann.bsky.social, Carol Greider, and Victor Ambros.

www.theguardian.com/commentisfre...

📌New bio constrained ANN learning rule: ➡️dendritic target propagation⬅️ considers cell diversity, compartmentalization, FF FB inputs, more. 🧠📈🤖🧪

7/7) As a final thought for funding, particularly for younger scientists, I am a strong advocate for the NSERC Discover Grant model:

- Smaller grants, with high success rate (~50%)
- Only one grant per lab
- Young researchers do not have to hit the same bar as established researchers to be funded

👀Interesting take from @stephanie-theves.bsky.social linking general intelligence and abstraction. One to watch. 🧪🧠📈🧠🤖🧠👩‍🔬 _ ?(emoji analogies seemed fitting)

Hippocampal ensembles regulate circuit-induced relapse of extinguished fear Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear

🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!

America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.

We agree. KenjiLee your data. @sabbaspoor.bsky.social's version uncovered surprisingly specific spike-field motifs and short latency spike timing interactions in macaque CA1: doi.org/10.1016/j.ce...

High–resolution laminar recordings reveal structure–function relationships in monkey V1 The relationship between the structural properties of diverse neuronal populations in the monkey primary visual cortex (V1) and their functional visual processing in vivo remains a critical knowledge ...

On behalf of Nicole Carr: new preprint from the Chand/Moore labs! High-resolution laminar recordings reveal structure-function relationships in monkey V1.

1/4

www.biorxiv.org/content/10.1...

As I try to wrap my head around my new field of affective science writ large and The Theory of Constructed Emotion specifically, @elisennesh.bsky.social has been helpful. For the many here who like to discuss "how we sciene", my sense is that TCE is a different approach than other ways.

"My instinctive reaction was to withhold this case from publication. The patient was my only sister."

An incredible article (still guarded behind a paywall by Oxford University Press, 90 years after publication)

Do everyone a favor and read this. Then act. 🧠📈🧪

#preprint:

We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography.

doi.org/10.1101/2025...

@yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social
@crick.ac.uk @esrf.fr

👀Come for the 3D microscopy porn, stay for the ensemble coding principle. I will never not like the olfactory circuit organization. Here’s a punchline post in the thread:

Stimulating vosstacular stim work, and another case of targeting lateral temporal lobe (not medial) for stim in humans. ❓🙋🏻‍♀️ to Joel/Jim: you did parietal stim before, so would you pick LTL or Par. for therapeutic target to address “MTL”ish memory impairment? Or neither?
🧠 📈 🧪

In spiking neural networks, neurons communicate - as in the brain - via short electrical pulses⚡(spikes). But how can we formally quantify the (dis)advantages of using spikes? 🤔

In our new preprint, @pc-pet.bsky.social and I introduce the concept of "Causal Pieces" to approach this question!

📌

Ten principles for reliable, efficient, and adaptable coding in psychology and cognitive neuroscience - Communications Psychology Programming is essential for modern research in neuroscience and psychology, but it can quickly become a source of frustration and error. This Primer introduces ten practical principles guiding resear...

Many processes from industry are not appropriate or overkill for an academic setting, but we can and should be doing better than we currently are.

Our paper tries to give practical advice on how you can improve your scientific workflow, without being a coding guru.

www.nature.com/articles/s44...

Yeah, in fact, those would be welcome! We may yet need to reach out, we’re still stepping through how to implement it.

And just imagine, if it’s possible to decode categories with LFP/iEEG, as here, what the possibilities are with neuronal ensembles…(stay tuned!)

Yes! Psst, don’t forget ripple density increase during active retrieval, that paved the way: doi.org/10.1016/j.cu...

Nice approach to “what happens in the wake of a ripple?”

I’m sure there’s an only fans for that?

Show them: My student and I are trying to implement your Bayesian approach b/c of this post. It’s a very different substrate (not genes) so would not have easily come up in a lit search: bsky.app/profile/cian...

Not saying its the right path, just that it’s my intuition