Cleanthis Michael

🎉 PINE Lab is hiring a postbacc Research Coordinator! Projects include cohort studies examining brain mechanisms linking adversity to cognition/language & RCTs of early interventions on neurodevelopment.
apply: forms.gle/Dyay39x2XEMn...
more info: www.plasticityinneurodevelopmentlab.com/join-us

My lab at UW Madison is hiring a new lab manager! I’m looking for a motivated and detail-oriented person to help run the lab’s day-to-day, including our ongoing neuroimaging and behavioral studies. This is especially well suited for graduating undergrads thinking about grad school. Link below

A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth Performance of five influential brain age estimation algorithms in two population-based cohorts of youth. Brain age was quantified using estimates of brain structure, and performance was evaluated ba....

A Systematic Evaluation of the Performance of Multiple Brain Age Algorithms in Two Cohorts of Youth
onlinelibrary.wiley.com/doi/full/10....

Grateful to all co-authors, mentors, and collaborators on this project - including Luke Hyde, @jamielarsh.bsky.social, @christophermonk.bsky.social, @colterm.bsky.social, Alex Burt, Kelly Klump, Natasha Jones, and Heidi Westerman!

Check out our new paper evaluating the performance of five brain age algorithms in two population-based cohorts of youth 🧠

@ohbmofficial.bsky.social

Nine subcortical/cerebellar atlases included in the subcortex_visualization Python package (and subcortexVisualizationR package in R). The atlases are depicted in two-dimensional vector graphic format.

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)!

Preprint: www.biorxiv.org/content/10.6...
Website: anniegbryant.github.io/subcortex_vi...

Thanks again for all your helpful input on this work, Val - really appreciate your support!

Thanks Ted!!

Super grateful for the amazing co-authors and collaborators who made this work possible:
@ted-satterthwaite.bsky.social, @bart-larsen.bsky.social, and my advisor Luke Hyde!

We highlight several avenues to further delineate how experience interacts with the plasticity of the developing human brain – longitudinal designs, multimodal in vivo indices of neuroplasticity, heterogeneity of adversity exposure, and consideration of nurturing and promotive experiences

Third, drawing from in vivo proxies of neuroplasticity (e.g., myelination, intrinsic activity, metabolite concentrations), we argue that adversity may dampen or amplify the magnitude of neuroplasticity

Second, neuroplasticity is itself malleable and sensitive to experience (i.e., plasticity as an outcome). Consistent with prior theory, we propose that adversity may accelerate or delay brain maturation, thereby shifting the developmental timing of neuroplasticity

For example, the neurobiological effects of adversity exposure may be more widespread, and localized to early-maturing limbic regions, earlier in life – but more localized to later-maturing prefrontal regions later in development

First, we discuss how the state and location of neuroplasticity during the timing of exposure may modulate how adversity becomes biologically embedded (i.e., plasticity as a moderator)

We next propose three ways in which experience, focusing on adversity, may interact with neurodevelopmental plasticity. Understanding these dynamics can help elucidate how experience shapes development, risk, and resilience, and may ultimately inform the type and timing of interventions

Synthesizing across developmental periods, we describe how neuroplasticity may be globally heightened during early childhood and localized later on, progressing along a sensorimotor-association axis across childhood and adolescence

Neuroplasticity has been difficult to define and assess – from process or capacity to change, to experience-dependent or expectant mechanisms, to separating experience-driven remodeling from development and genetic programming. We focus on plasticity as the brain’s capacity to adapt to experience

Excited to share our new review “Mapping interactions between adversity and neuroplasticity across development” in @cp-trendscognsci.bsky.social. We discuss how experience - particularly adversity - interacts with neuroplasticity during human development authors.elsevier.com/c/1mB5U4sIRv...

neuroimaging | Satterthwaite Lab | UPenn www.satterthwaitelab.com Homepage for Satterthwaite lab neuroimaging | neurodevelopment | adolescence | psychiatry | machine learning | network science

#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs.

Website: www.pennlinc.io

Job: bit.ly/4ojvCir

Happy to share our review "Investigating hierarchical critical periods in human neurodevelopment” in @npp-journal.bsky.social! We examine neurobiological, environmental & behavioral evidence for human critical periods in sensory and association cortex +discuss new research directions rdcu.be/eMkVU 🧵

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

How do brain networks tracking past trauma react to stress in the future? Thrilled to share new work from the lab led by rockstar postdoc @felhardi.bsky.social with wonderful collab @dylanggee.bsky.social
www.pnas.org/doi/10.1073/...
#psychscisky #neuroskyence

thrilled to share this project over a decade in the making out now in @pnas.org! We show that precocious GABA boosting in neonates by early sevoflurane/propofol anesthetic exposure accelerates visual cortical maturation in human infants
www.pnas.org/doi/10.1073/...

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence?
We asked this in our new paper just out in #ScienceAdvances ✨
“Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling”
📄 www.science.org/doi/full/10....
🧵⤵️

Huge congrats Elena!!

Precise individual measures of inhibitory control Nature Human Behaviour - Collecting an extensive publicly available dataset on four inhibitory control tasks, Gratton et al. show that more than 1,000 trials per participant are necessary to reduce...

Excited to announce that our paper (led by @hyejinjadelee.bsky.social & Derek Smith) is out in @nathumbehav.nature.com
go.illinois.edu/Lee2025_NHB
We use 36 days of testing in 4 inhibitory control tasks to examine the precision of inhibitory control measures in *individuals* and how they vary
🧵👇

The history and future of resting-state functional magnetic resonance imaging - Nature This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

a yellow sign that says we 're hiring ALT: a yellow sign that says we 're hiring

We are hiring a post-bacc research coordinator to help on projects exploring EEG and MRI measures of neuroplasticity supporting sensory and language learning in the first 2 years of life! Please repost to help us spread the word! more info here: www.plasticityinneurodevelopmentlab.com/join-us