T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots - Nature Immunology Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8+ T cell epitope recognition.

The JN.1 variant of SARS-CoV-2 resulted in a major Covid wave a year ago. A new report uncovers T cell immune evasion as a mechanistic basis. We've been preoccupied on neutralizing antibodies, not enough on cell-based immunity to the virus.
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