Vilja Oired

Plasma p-Tau217 and Amyloid Burden in Older Adults Without Cognitive Impairment This meta-analysis examines data for the accuracy of plasma phosphorylated tau 217 tests from published studies that compared older adults without cognitive impairment who were amyloid positive vs amy...

”Plasma measures of p-tau217 can accurately identify individuals in the preclinical stage of Alzheimer disease where interventions are likely to have the most benefit in delaying or stopping disease progression.”

People with blindness can read again after retinal implant An electronic eye implant has restored vision in people with blindness caused by age-related macular degeneration.

An implant that cures blindness, fantastic news for AMD patients! This could bring bionic sight within reach.

‘The Pitt’ Has Inspired More Organ Donation and End-of-Life Planning, According to USC Norman Lear Center Study After just one season, Emmy-winning drama “The Pitt” is already having an impact on healthcare conversations. That’s the finding from a new study released Monday by the USC Norman Lear Center, which said “The Pitt” has shifted the conversation on issues such as organ donation and end-of-life planning. According to a group of 1,409 viewers […]

'The Pitt' Has Inspired More Organ Donation and End-of-Life Planning | Michael Schneider for Variety (@Variety)
https://variety.com/2025/tv/news/the-pitt-organ-donation-end-of-life-planning-study-1236562186/

A Long Road to a Landmark Moment in Palliative Care Research | AAHPM Kyle P. Edmonds, MD FAAHPM Clinical Professor at UC San Diego Health Sciences Health Policy Strategic Coordinating Commitee Chair When I first walked the halls of Capitol Hill in 2013 […]

A landmark moment for palliative care research! Discover the long journey that led to this breakthrough and why it matters for patients and clinicians. Read the full blog here: https://ow.ly/k31F50XkpUv

Selection bias could be the cause. But artificial sweeteners trigger insulin: A) Short term they move sugar into non-brain cells, causing relative brain hypoglycemia. B) Long term they drive insulin resistance, with or without meeting diabetes criteria, but cognitive decline expected.

How do vaccines reduce the risk of dementia? | University of Oxford A new study by the University of Oxford, published in the journal npj Vaccines, shows that a vaccine against respiratory syncytial virus (RSV) is associated with a 29% reduction in dementia risk in

Interesting🤔

Like much of human nature, it’s a question of trust - just like when elevators first switched from human operators to automation. People were skeptical, even afraid. Now, no one asks for a lift operator.

Robotic surgery outperforms laparoscopic in rectal cancer. Next step: train robots using AI like that in self-driving cars and humanoids. How long before an AI-driven robot beats the surgeon-controlled one?

Excess US Deaths Before, During, and After the COVID-19 Pandemic This cohort study examines trends in excess deaths in the US before, during, and after the COVID-19 pandemic.

Excess death in US compared to other high-income countries. This trend can probably only be broken by the Ozempic-pandemic🤔 and maybe some sensible healthcare reforms💡.

Superhuman performance of a large language model on the reasoning tasks of a physician.

arxiv.org/abs/2412.10849

Hospitalized patients with dementia are infrequently present in GOC conversations and less likely to have their values and preferences for medical care documented within a GOC note. #geriatrics #palliativecare agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

DeepMind unveils ‘spectacular’ general-purpose science AI System improves chip designs and tackles unsolved maths problems, but has not been rolled out to researchers outside the company.

Human(?) development is about to jump to hyperspace. With small tweaks, this could be applied to everything from scientific research to factory floors and logistics.

A graph showing the adjusted population-attributable fraction of obesity classes for prevalent health conditions

“Our study demonstrated associations between obesity, particularly severe obesity, and the incidence of 16 common health outcomes.” 📋 Read the full study results by Z. Yao et al. in NEJM Evidence: eviden.cc/4iIRjGg

#MedSky #EndoSky

KDIGO heat map for CKD classification.

Heart and Kidney disease are related. Many patients have both, leading to CKM syndrome. http://spr.ly/6048uP0fo

As many as 9 in 10 adults with CKD don't know they have it. Kidney disease usually has 0 symptoms, & many people don’t know they have it until it’s very advanced.

Symptom support, unbiased and pure. Taking on the toughest cases: elderly patients. Get diagnoses and suggested investigations. Powered by our own AI (not Big Tech), but we use LLM as a sidekick. Easy, no login, free to use: Oired.com

The New England Journal of Medicine Extended Reduced-Dose Apixaban for Cancer-Associated VTE A Research Summary based on Mahé I et al. | 10.1056/NEJMoa2416112 | Published on March 29, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In the API-CAT trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events. Full trial results and Research Summary: nej.md/41YkRZK

#MedSky

In Type 2 Diabetes SLGT2 decreased risk of Alzheimer with 43% and GLP-1 with 33% compared with other DM2 medications. No significant difference between SLGT2 and GLP-1.

jamanetwork.com/journals/jam...

Read, learn, think and challenge yourself should be added throughout life.

Zoster vaccine reduced the probability of a new dementia diagnosis by approximately 20% over a seven-year follow-up period.

First, jab more babies As aid shrinks, donors and recipients should focus more on health

”On average, each dollar spent on vaccination yields a hefty $54 in returns.” - That is a good investment!

NEJM: Global Effect of Cardiovascular Risk Factors on Lifetime Estimates. With all 5 risk factors (high blood pressure, high cholesterol, diabetes, smoking, and unhealthy body weight) at age 50 lifetime cardiovascular disease risk was 38% in men and 24% in women.

www.nejm.org/doi/full/10....

Treating coronary artery disease risk factors early could make it a rare disease. But are we ready to take pills to prevent a disease that might occur 40 years later? Of course, a middle way already exists in clinical practice. However, this Lancet Commission rightly highlights prevention.

Retirement Can Harm Your Brain. Here’s How to Keep It Healthy. It’s challenging to stay mentally sharp and healthy through the major transition. Careful planning is key.

About to retire, prepare yourself or risk cognitive decline.

America's aging population faces a growing shortage of geriatric care For a variety of reasons, geriatric care experts told BI it's been hard attracting new doctors to the field. It's a problem for an aging US population.

The number of geriatricians is shrinking, just 7,400 in 2022, down from 10,000 in 2000, while the aging population keeps growing. The American Geriatrics Society says we’ll need 30,000 by 2030. The math isn’t adding up!

graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

"Kindness is like snow—it beautifies everything it covers." ~ Khalil Gibran

#Kindness cannot prevent, slow or cure #Alzheimers. But the presence or absence of kindness fundamentally changes quality of life for people experiencing #dementia and those who are #caregiving.

#quote

Or could the relative decline in dementia be partly due to the increasing use of smartphones among older people? A constant flow of information and interactions, which stimulate thought and keep the brain active, proven by how hard it is to get someone’s attention when they’re on their phone.

Gene repair inside the human body is now a reality.

Updated.