andrewpgrieve.bsky.social

At times I've used all three, but I'm a medievalist at heart.

Do statisticians count? A personal view The number of statisticians working in the pharmaceutical industry has risen 50-fold since the formation of PSI in 1977. It would be comforting to think that the influence of statisticians within the...

Couldn't agree more. Grieve's 1st Law of Influential Statisticians: design, design, design = D to the power 3.

doi.org/10.1002/pst.5

I'm convinced the solution is to train more statisticians and include them as team members. Had this discussion with a UK MRC toxicologist 20 years ago who wanted more statistical support to prevent the copying from subject matter journals of incorrect, out-of-date methods.

From the New York Times.

Used to make these at University in the early 70s. Delicious.

Sad to hear of the passing of Danny Thompson. First heard him with Alexis Korner's Blues Incorporated in the 1960s, followed by Pentangle. It was only couple of weeks ago that I listened again to the BBC recordings of his trio with John McLaughlin from 1967.

Fieller's theorem by Edgar Fieller.
Should it be pronounced F - ee- ller's theorem or F - eye- ller's. I know how his son Nick, statistician at Sheffield University, pronounced it.

I remember seeing "Barefoot in the Park" at boarding school, and skipping out of school on a Satrurday night to go and see Butch Cassidy and the Sundance kid with these guys in 1968, it's me on the left, in white jumper.

Back in the Netherlands, for September. 1st beer of the trip.

I checked my own papers to make sure I haven't committed this sin. I haven't yet. I have used the phrase "seminal paper" three times in describing Armitage, McPherson and Rowe's paper on multiple sequential testing, Ross Prentice's on surrogate endpoints and Harold Wikensky's on professionization.

I am disappointed. When I lived in Köln, Turkish pastries were one of my guilty pleasures.

I would have been able to make a lot of tarte tatins with them.

Plum and apple tarte tatin for Sunday meal with the whole family before we decamp to the Nethrrlands for a month.

I'm with you.

In Würenlos (CH) with friends from Basel for a long weekend.

It sounds like the modern equivalent of, "Those who can, do. Those who can't, teach." The modern version being, "Those who can, research. Those who can't, meta-science."

Me sat next to the author (Douglas Adams) in the dormitory at boarding school in 1967.

...and not because the techniques are appreciated to be scientifically important"

Sir David Cox

"One does feel that statistical techniques both of design and analysis are sometimes adopted rather as rituals designed to assuage the last holders of absolute power (editors of journals) and perhaps also regulatory authorities, ....

Or the other way around.

Lunch at The Pig at Bridge.

Pre-Friday Night Ex-Pfizer Cricketers curry. Otter Ale.

I suspect there were similar studies in the 70s looking at what calculators did to students' brains.

I used that train frequently when I worked in Köln and the kids were still living in the UK. Missed the connection on a number of occasions and became a regular in the Pullman Brussels Midi.

Wild Beer? Too true, 13%.

"The main difference between Bob Temple and me", I replied, "is that I'm a statistician who doesn't think he's a clinician."

I was sat in a meeting in corporate HQ in NYC in 1999 & opposite me were two clinicians. They both looked at me & chuckled. "What's so funny?" I asked. "He just said you look like a young Bob Temple".

Didn't expect to see them this morning !!

I recall saying this to a drug development team in New York at the turn over the millennium. I overheard one physician saying to another, if we had to develop drugs in that way we'll never get approvals.

I told them you're not getting European approvals, which is the purpose of this meeting.

I've always regarded it as part of Good Clinical Practice (GCP) in drug development. In simple terms GCP requires us to

1) say what you are going to do
2) do what you said you were going to do
3) verify you did what you said you were going to do.