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Billy Marsiglia

@billymarsiglia.bsky.social

Assistant Professor and Chemical Biologist at UAB studying protein-protein interactions in the PI3K-AKT pathway. He/him marsiglialab.com

139 Followers  |  650 Following  |  4 Posts  |  Joined: 08.11.2024  |  1.5591

Latest posts by billymarsiglia.bsky.social on Bluesky

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Excited and thankful to announce that our lab received its first NoA for an R35 MIRA award from NIGMS! This funding will support research focused on dissecting the biophysical mechanisms of AKT activation that are dysregulated in disease. Grateful for an awesome team and community at UAB.

18.08.2025 17:30 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We found that T308 phosphorylation allosterically enhances the binding of ATP-competitive inhibitors and influences their effectiveness on triple-negative cancer cell lines. Great work done by Jeremy Harris, Dr. FlΓ‘vio AntΓ΄nio de Oliveira SimΓ΅es, and Erin Ryerson!

24.03.2025 15:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Live-cell NanoBRET assay to measure AKT inhibitor binding to conformational states of AKT AKT is the main protein kinase of the PI3K-AKT pathway, interacting with over one hundred protein partners to facilitate cellular processes that allow cancer cells to survive and proliferate. It is an...

Excited to highlight the first pre-print from my lab on bioRxiv! We used live-cell NanoBRET target engagement assays to measure ATP-competitive and allosteric AKT inhibitors binding to all AKT isoforms.

www.biorxiv.org/content/10.1...

24.03.2025 15:44 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Proud to introduce my lab! Our group studies protein-protein interactions in the PI3K-AKT pathway using BRET and structural biology-based approaches. We aim to visualize the interactions of AKT with its protein partners and understand how AKT inhibitors influence the formation of those interactions.

05.12.2024 23:15 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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