Jorge Castorena

Happy Birthday, next time have them include Cookie Monster!

Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!

Congrats, Manuel!

Congrats to all the @taijamakinenlab.bsky.social group!

This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images

Thank you very much for the nice review and highlight of our work.

scRNAseq of🐭collecting lymphatic vessels😎

Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity

@maryschulz.bsky.social
@jcastorena.bsky.social
#ATVB 2025
www.ahajournals.org/doi/full/10....

Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.

Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the p...

Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/...

@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social

Got any lymphatics?

It looks like a huge vessel, based on lumen size… maybe a pig, horse, or monkey?

Frontiers | Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes

Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out.
www.frontiersin.org/journals/phy...

Congrats, Manuel! This is a very well deserved recognition of your impactful work.

Insulin regulates lymphatic endothelial integrity via palmitoylation Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …

Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.

Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏

www.sciencedirect.com/science/arti...

Congrats to you, Silvia, and the entire team!

We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky

Many saw this coming, unfortunately not enough. We’ll have to work through the new extra barriers they’ll put in front of us, and continue to do what we love doing.

🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕