Florian Sure

Acute activation of human epithelial sodium channel (ENaC) by serum and glucocorticoid inducible kinase 1 (SGK1) requires prior cleavage of the channel’s γ-subunit at its proximal cleavage site - Pflü... Serum and glucocorticoid inducible kinase 1 (SGK1) is a key regulator of the epithelial sodium channel (ENaC). In rat ENaC, the serine residue 621 (S621) in the channel’s α-subunit is essential for ac...

We have a new paper out in Pflügers Archiv! 🎉 We show that acute activation of ENaC by SGK1 critically depends on cleavage of the γ-subunit, indicating an interaction between kinase and protease pathways.

doi.org/10.1007/s004...
#ENaC #SGK1 #Physiology #IonChannels #KidneyResearch

Automated patch clamp for ENaC drug discovery - Nanion Technologies The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...

In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.

Read more here:
www.nanion.de/news/automat...

Happy to share our recent research @fau.de on how to measure ENaC using automated patch clamp technique on a platform developed by @naniontech.bsky.social 🎉 doi.org/10.1007/s00424… #research #ENaC #APC #Science