Nanion Technologies

SyncroPatch 384 Research Grant - Nanion Technologies In 2025, we are offering the chance for you to win a SyncroPatch 384 for 9 months.

𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗿𝗲 𝗼𝗽𝗲𝗻 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁!

Get 9 months with the system, consumables, and full support to accelerate your research.

Deadline: Oct 31. Apply now!

ow.ly/9gx050X0OOW

#APC #IonChannels #Electrophysiology

Reduce variability in NaV studies with adaptive voltage clamp on the SyncroPatch 384.

Tailor Vhalf per well, gain better IC50 precision, and study state-dependent effects with confidence.

Check out the flyer to see how it works!
ow.ly/8QMU50WFXei

#APC #IonChannels #NaV #Electrophysiology

How do CaV1.2 mutations drive both arrhythmias and neuro symptoms in Timothy syndrome?

Join Ivy Dick on June 12 to learn how high-throughput patch clamp reveals mutation-specific gating changes tied to clinical outcomes.

📍https://ow.ly/PxZY50W72H7

#PatchClamp #Channelopathies #IonChannels

Automated patch clamp for ENaC drug discovery - Nanion Technologies The epithelial sodium channel (ENaC) plays a central role in regulating sodium balance, blood pressure, and pulmonary fluid clearance. Despite its clinical relevance, progress in discovering new ENaC-...

In a recent study, researchers developed and validated an automated #patchclamp ( #APC ) approach using the SyncroPatch 384 platform to detect #ENaC - mediated currents in a high-throughput format.

Read more here:
www.nanion.de/news/automat...

Most cardiac gene variants are still classed as “uncertain.”

Join us on Thursday to learn how APC is helping reclassify VUS and improve clinical decisions.

🗓️ May 8 | 16:00–17:00 CEST
🔗 ow.ly/RQfB50VFl93

Hope to see you there!
#CardiacGenetics #APC #VUS #LQTS #Brugada

How do beta-lactam antibiotics get into our cells, and how can we use that to design better drugs?

Join our webinar on May 14 to explore new insights into PepT2, drug uptake, and delivery.

🔗 Register: ow.ly/1mCL50Vo2j8

#PepT2 #DrugDesign #CryoEM #Webinar

Why is NHE9 active in endosomes but silent at the membrane?

A new Nature Communications study reveals a lipid switch: PI(3,5)P₂ stabilizes NHE9’s dimer only in endosomes.

🔗Read the full article to find out more: ow.ly/zrsR50VAAZW

#MembraneTransport #CryoEM #SSME

Webinar: Understanding antibiotic uptake via PepT2 - Nanion Technologies Date: May 14, 2025 Time: 16:00 – 17:00 CEST Location: Online via Zoom

Join us in exactly one month for our next transporters webinar!

Dr. Joanne Parker (University of Oxford) will present research insights on PepT2 (SLC15A2), a key player in beta-lactam antibiotic transport.

📅 May 14, 2025 | 🕓 16:00–17:00 CEST

🔗 Register here: ow.ly/1mCL50Vo2j8

#MembraneTransport

𝗖𝗮𝗻 𝘄𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲 𝘁𝗵𝗲 𝘄𝗮𝘆 𝘄𝗲 𝗶𝗻𝘁𝗲𝗿𝗽𝗿𝗲𝘁 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗴𝗲𝗻𝗲 𝘃𝗮𝗿𝗶𝗮𝗻𝘁𝘀?

Join Dr. Chai Ng (Victor Chang Cardiac Research Institute) on May 8 to explore APC’s role in variant classification for inherited arrhythmias.

🔗 ow.ly/XrnO50VymFI

#Webinar @chaiannng.bsky.social @victorchang.edu.au

iPSC-CMs are powerful, but their immaturity limits their predictive value. A recent study from TU Dresden shows how combining metabolic medium, nanopatterning, and electrostimulation significantly enhances structural and electrophysiological maturation.

🔗 lnkd.in/dipXpmyN

#Cardiac #iPSC #APC

TRPV3 is a temperature-sensitive, ligand-gated ion channel known for its role in warmth perception.

It can be activated by heat (~ 38˚C) or by 2-APB, and we have explored both activation modes using APC with temp control.

Read the app note: ow.ly/YMp850R6hwG
#TRPV3 #IonChannels #Electrophysiology

Cryo-EM reveals how cholesterol and sphingomyelin shape the structure and stability of a membrane pore formed by the toxin Fav.

Electrophysiology with the Orbit Mini confirms cholesterol reduces current noise.

🔗 Read more in the paper: ow.ly/sPmJ50VusCf

#CryoEM #MembraneBiophysics #Orbitmini

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗲𝘁𝗮-𝗹𝗮𝗰𝘁𝗮𝗺 𝗮𝗻𝘁𝗶𝗯𝗶𝗼𝘁𝗶𝗰𝘀 𝗲𝗻𝘁𝗲𝗿 𝘁𝗵𝗲 𝗯𝗼𝗱𝘆?
And why does it matter for drug design?

Join us on May 14 as Joanne Parker (University of Oxford) presents new insights into the structure and function of PepT2, a key transporter in beta-lactam pharmacokinetics.
ow.ly/1mCL50Vo2j8

#MembraneTransport

Understanding cardiac function needs more than one readout

This flyer shows how combining electrophysiology, contractility & viability data offers deeper insights into drug effects & disease models.

Discover more in the flyer: ow.ly/LGRs50VnV0o

#CardiacResearch #iPSC

Studying pore-forming toxins? At Nanion, we provide advanced tools - parallel bilayer recording stations, GUVs, and planar patch clamp systems - to help researchers get a clearer picture of how these toxins work.

Learn more: www.linkedin.com/feed/update/...

#PFT #toxins #electrophysiology

Working with toxins & ion channels? Testing multiple fractions and screening channels with limited samples is tough. That’s why more scientists are turning to automated patch clamp for faster, reliable results. Curious? Learn more: www.nanion.de/application-... #ionchannels #toxins #patchclamp

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝗣𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺!

From ion channels to drug discovery—discover what’s next in electrophysiology. Connect with leading experts in Napa Valley!

📅 Apr 30–May 1

𝗟𝗶𝗺𝗶𝘁𝗲𝗱-𝗧𝗶𝗺𝗲 𝗢𝗳𝗳𝗲𝗿: 𝟭𝟱% 𝗢𝗳𝗳 𝗧𝗶𝗰𝗸𝗲𝘁𝘀
Register now 🔗 ow.ly/SmfE50VgoHz

#MPS25 #MembranePhysiology

Venom-derived toxins offer unique precision in ion channel research. We tested Huwentoxin-IV, TTX, GsMTx4 & α-Conotoxin MI on NaV1.7 and nAChR to explore their blocking effects. Want to learn more?
Read more in the full study: ow.ly/bKoG50Vgpy3
#IonChannels #DrugDiscovery #APC

Optical control of Kv1.2 channels via azobenzene-modified charybdotoxin - Nanion Technologies Animal venom peptides like charybdotoxin (ChTx) are known for their high specificity and potency as potassium channel blockers, making them valuable tools in ion channel research. However, achieving p...

In a pioneering study, Achouba et al. successfully integrated photoswitch technology into a complex, disulfide-rich peptide ChTx while retaining high nanomolar potency for ion channels.

Read more here:
www.nanion.de/news/optical...

#ionchannels #optogenetics #patchclamp #APC #venom #toxins

𝗛𝗲𝗮𝗱𝗶𝗻𝗴 𝘁𝗼 𝗡𝗲𝘅𝘁𝗚𝗲𝗻 𝗕𝗶𝗼𝗺𝗲𝗱 𝟮𝟬𝟮𝟱? 𝗟𝗲𝘁’𝘀 𝗖𝗼𝗻𝗻𝗲𝗰𝘁!

Meet us at Booth #60 to see AtlaZ in action—now GxP compliant! Get real-time, label-free insights into cell activity & viability and explore its impact on drug discovery & immuno-oncology.

🔗 ow.ly/nl0s50Vafhh

#NextGenBiomed #GxP #AtlaZ

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗖𝗮𝗿𝗱𝗶𝗮𝗰 𝗦𝗮𝗳𝗲𝘁𝘆 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝟮𝟬𝟮𝟱!

📅 May 21, 2025 | 🌍 Virtual

The symposium will bring together experts to discuss the latest advancements in safety pharmacology, cardiac physiology, and electrophysiology.

🔗 Learn more and register here 👉 ow.ly/VvWl50TPkbR

#CardiacSafety #Pharmacology

AtlaZ now offers 𝗙𝗗𝗔 𝟮𝟭 𝗖𝗙𝗥 𝗣𝗮𝗿𝘁 𝟭𝟭 𝗰𝗼𝗺𝗽𝗹𝗶𝗮𝗻𝗰𝗲, ensuring secure, traceable, and audit-ready data for regulated research.

✅ Secure access & user tracking
✅ Audit trails & data integrity
✅ Compliance made simple

📄 Learn more: ow.ly/Oaln50V6Qk3

#CellAnalytics #GxPCompliance #21CFRPart11

Our latest case study highlights how Frédéric Becq from the University of Poitiers uses automated patch-clamp technology to deepen our understanding of CFTR function and its interactions with drugs.

Read more here: www.nanion.de/wp-content/u...

#ionchannels #CFTR

𝗛𝗼𝘄 𝗰𝗵𝗮𝗻𝗻𝗲𝗹𝗼𝗽𝗮𝘁𝗵𝗶𝗲𝘀 𝗮𝗿𝗲 𝗮𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆? 🧬

Mutations in ion channels are linked to 1,300+ genetic disorders, many driving rare diseases. Understanding these mutations enables faster, more precise profiling, crucial for targeted therapies.

🔗 ow.ly/C0ST50V60SB

#RareDiseases #DrugDiscovery

The INNOVATION consortium is shaping the next generation of researchers! At our recent meeting, students gained hands-on training while project leaders planned the next steps. Exciting progress in RBC ion channel research. Looking forward to future breakthroughs! 🚀
#IonChannels #Electrophysiology

Silent Molecular Translocation

Some molecules move through nanopores without altering ionic currents, remaining invisible to traditional methods. The Orbit mini captures these silent events using optical + electrical recordings, unlocking new insights in biophysics & diagnostics ow.ly/HLFM50V16oS

Light-gating of potassium-selective channelrhodopsin - Nanion Technologies Channelrhodopsins (ChRs) are light-sensitive ion channels widely used in optogenetics to precisely control neuronal and cardiac activity. While most ChRs conduct cations non-selectively, a specialized...

A recent study provides detailed structural insights into how potassium-selective channelrhodopsins (KCRs) function.

Read here:
www.nanion.de/news/light-g...

#ionchannels #optogenetics #patchclamp #APC

The Biophysical Society Meeting, starts today!

Check out our activities:

🔹 Ion channel drug discovery at our Satellite Meeting - Today!
🔹 Booth #509 – Live demos & latest innovations
🔹 Feb 17, 11:30 AM – Join us at our Exhibitor presentation
🔹 Don´t miss out on our Posters
lnkd.in/dPKd-Q2B

#BPS25

Join us at the Membrane Physiology Symposium 2025!

📅 April 30 – May 1, 2025
📍 Napa Valley, CA

Two days of cutting-edge science, expert talks, and networking in a stunning location. Connect with top researchers and industry leaders.

🔗 Register now: lnkd.in/dW23dG-t

#MPS25 #MembranePhysiology

Phentolamine inhibits NaV channels – is it fit for anaesthesia reversal? - Nanion Technologies Phentolamine, a non-selective α-adrenoreceptor antagonist, is widely used in clinical settings to reverse local anaesthesia by promoting vasodilation and drug clearance. While generally well tolerated...

A recent study from @lampertlab.bsky.social demonstrates that phentolamine inhibits NaV1.7 and NaV1.5 channels through the local anaesthetic receptor site, a mechanism that may conflict with its intended use as an antidote for local anaesthetic toxicity.
www.nanion.de/news/phentol...

#ionchannels