Endocrinology Advisor

Reproductive Endocrinologist Found Liable for Failing to Diagnose Ovarian Cancer A reproductive endocrinologist was found liable in a medical malpractice lawsuit after failing to diagnose a patient with ovarian cancer.

A #ReproductiveEndocrinologist was sued for #MedicalMalpractice after a patient received a diagnosis of #OvarianCancer after undergoing #FertilityTreatment.

Central Precocious Puberty Elevates Psychiatric Disorder Risk Central precocious puberty was associated with elevated risk for psychiatric disorders including depression, ADHD, and anxiety.

#CentralPrecociousPuberty elevated risk for #MentalDisorders as early as 1 year before diagnosis and up to 8 years after diagnosis.

@unidue.bsky.social @ruhr-uni-bochum.de

GLP-1RAs Better Reduce Amputation Risk Than SGLT2is in T2D GLP-1RAs were associated with significantly reduced risk for amputations relative to SGLT2is among patients with type 2 diabetes.

#Amputation risk was significantly reduced among patients with #T2D who used #GLP1RAs compared with #SGLT2is.

@dgarmstrong.bsky.social @keck.usc.edu @uscsurgery.bsky.social

Endocrine Society Archives Presenting research from ENDO, the annual meeting of the Endocrine Society.

Still catching up on research from #ENDO2025? Find all of Endocrinology Advisor's coverage from this month's conference below ⬇️ @endocrinesociety.bsky.social

SGLT2 Inhibitor Use Linked to Increased Risk for Erythrocytosis, Not Thrombosis SGLT2 inhibitor use was associated with an increased risk for erythrocytosis but not thrombosis among patients with type 2 diabetes.

Relative to #GLP1RA and #DPP4i use, #SGLT2i use was associated with an increased risk for #erythrocytosis but not an increased risk for #thrombosis in #T2D.

Weight Loss-Induced Sex Hormone Changes May Affect BMD Loss in T2D Weight loss-induced sex hormone changes had a mediating effect on bone mineral density loss among patients with type 2 diabetes.

Changes in #BoneMineralDensity were mediated by changes in E2 and testosterone among women and men, respectively, with #T2D undergoing weight loss.

@erinmichos.bsky.social @johnshopkinssph.bsky.social @jhu.edu @imperialcollegeldn.bsky.social @uthsc.bsky.social

Academic Detailing Plus Pre-Visit Handout Improves Diabetes Deprescribing Academic detailing plus pre-visit patient activation was associated with sustained diabetes deprescribing rates at 12 months in older adults with T2D.

Pre-visit patient activation enhanced the positive effect of PCP academic detailing on diabetes #deprescribing rates among older adults with #T2D.

@kaiser-permanente.bsky.social @yaleschoolofmed.bsky.social

Linzagolix Sustains Reduced Menstrual Bleeding in Uterine Fibroids at 1 Year Linzagolix therapy was associated with significantly reduced heavy menstrual bleeding by week 52 among patients with uterine fibroids.

Reduced heavy menstrual bleeding was sustained with #linzagolix therapy, regardless of adjunct hormonal add-back therapy, at 1 year among patients with #UterineFibroids.

@yaleschoolofmed.bsky.social @ox.ac.uk @goetheuni.bsky.social @ub.edu

Gestational Glucose Intolerance, Diabetes Influences Childhood Obesity Gestational glucose intolerance was associated with increased risk for obesity and overweight, especially among children aged 11 to 18 years.

#Gestational #GlucoseIntolerance was associated with increased #obesity risk, especially among children aged 11 to 18 years.

@cepowemd.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Paltusotine Improves Patient-Reported Acromegaly Symptoms Paltusotine treatment is associated with significant reductions in patient-reported symptom severity among patients with acromegaly.

From #ENDO2025: There are significant reductions in patient-reported symptom severity among patients with #acromegaly treated with paltusotine.

@endocrinesociety.bsky.social

Veligrotug Safe, Efficacious for Active TED Veligrotug demonstrated significant improvements in proptosis, diplopia, and clinical activity score among patients with active thyroid eye disease.

From #ENDO2025: Veligrotug vs placebo was associated with significant improvements in #proptosis, #diplopia, and clinical activity score in active #ThyroidEyeDisease.

@endocrinesociety.bsky.social @uwmedicine.bsky.social @bcmhouston.bsky.social @keck.usc.edu @stanfordmedicine.bsky.social

Tirzepatide Cardiometabolic Benefits Greater in Women vs Men Tirzepatide yielded greater cardiometabolic benefits, especially in total cholesterol, LDL cholesterol, and weight loss, among women than men.

From #ENDO2025: Among #tirzepatide users, women experienced greater reductions in total #cholesterol, LDL cholesterol, and weight than men.

@endocrinesociety.bsky.social @mayoclinic.org

Diazoxide Choline Extended-Release Safe for Hyperphagia in Prader-Willi Syndrome Diazoxide choline extended-release tablets demonstrated favorable safety profile across 4 years among patients with Prader-Willi Syndrome.

From #ENDO2025: Diazoxide choline extended-release tablets for #hyperphagia demonstrated favorable #glycemic safety across 4 years among patients with #PraderWilliSyndrome

@endocrinesociety.bsky.social @nationwidekids.bsky.social @seattlechildrens.org

Adolescents With PCOS Show Modest Weight Loss After Bariatric Surgery Adolescents with PCOS demonstrated comparable weight loss to their reproductively normal peers after undergoing bariatric surgery.

From #ENDO2025: #BariatricSurgery #WeightLoss outcomes were comparable between adolescent girls with and without #PCOS.

@endocrinesociety.bsky.social @nufeinbergmed.bsky.social @umnsph.bsky.social @tamu.bsky.social @cincychildrens.bsky.social @luriechildrens.bsky.social

Thyroid Cancer Burden Due to High BMI on the Rise in US Thyroid cancer burden attributable to high BMI was increasing between 1990 and 2021 in the US, especially among men and older adults.

From #ENDO2025: #ThyroidCancer attributable to high #BMI increased from 1990 to 2021, especially among older adults and men.

@endocrinesociety.bsky.social

Adrenal Adenomas May Attenuate Weight Loss With Incretin-Based Therapy Adrenal adenomas were associated with attenuated weight loss among patients with obesity or overweight using GLP-1 or GIP/GLP-1 RAs.

From #ENDO2025: Presence of #adrenal #adenoma was associated with lower #WeightLoss among patients with #obesity using #GLP1 or GIP/GLP-1 receptor agonists.

@endocrinesociety.bsky.social

Tirzepatide Superior to Semaglutide in T2D Therapy Targets Tirzepatide was superior to semaglutide in achieving standard and intensive cardiometabolic targets among patients with type 2 diabetes.

From #ENDO2025: #Tirzepatide was superior to #semaglutide in achieving standard and intensive #cardiometabolic targets among patients with #T2D.

@endocrinesociety.bsky.social

Glucopilot Dynamic Dosing Algorithm for IV Insulin Therapy Improves Hypoglycemia Glucopilot dynamic dosing algorithm was associated with improved glycemic control especially among subgroups with hard-to-manage glycemia.

From #ENDO2025: Glucopilot dynamic dosing algorithm improved #glycemia management, especially among patients with #diabetic #ketoacidosis, #sepsis, and #steroid use.

@endocrinesociety.bsky.social @jhu.edu

Crinecerfont Maintains A4, GC Reductions in Pediatric CAH at 1 Year Crinecerfont is associated with sustained reductions in androstenedione and GC doses at 1 year in congenital adrenal hyperplasia.

From #ENDO2025: In pediatric #CongenitalAdrenalHyperplasia, crinecerfont is associated with sustained reductions in androstenedione levels and #glucocorticoid doses at 1 year.

@endocrinesociety.bsky.social

PCOS May Increase Vascular Event Risk in Thrombotic Disease PCOS was associated with an increased risk for vascular events including stroke among women with thrombotic disease, and a lower mean age.

From #ENDO2025: Women with #thrombotic disease and comorbid #PCOS had higher rates of #vascular events and presented at a younger age than those with thrombotic disease and no PCOS.

@endocrinesociety.bsky.social

COCPs Improve Obesity Outcomes in Hyperandrogenic PCOS COCPs were associated with improved obesity outcomes among patients with hyperandrogenic PCOS, but metformin added little benefit.

From #ENDO2025: Although the addition of #metformin offered little benefit, combined #OralContraceptive pills were associated with improved #obesity outcomes in hyperandrogenic #PCOS.

@endocrinesociety.bsky.social @upenn.edu

Hormone Therapy Plus Tirzepatide Enhances Postmenopausal Weight Loss Hormone therapy as an adjunctive to tirzepatide was associated with greater weight loss than tirzepatide alone among postmenopausal women.

From #ENDO2025: #HormoneTherapy plus #tirzepatide was associated with greater #WeightLoss than tirzepatide among #postmenopausal women.

@endocrinesociety.bsky.social @mayoclinic.org

Osteoporosis Treatment After Fragility Fracture Lowers Mortality Risk Osteoporosis treatment was associated with reduced hospitalization and mortality risks following fragility fracture after 80 years of age.

From #ENDO2025: #Osteoporosis treatment following fragility #Fracture was associated with significantly reduced #hospitalization and mortality risks among patients aged 80 years and older.

@endocrinesociety.bsky.social @clevelandclinic.bsky.social @upstatemedical.bsky.social

Setmelanotide Safe, Efficacious in Treating Acquired Hypothalamic Obesity Setmelanotide was associated with significant weight reduction among patients aged 4 years and older with acquired hypothalamic obesity.

From #ENDO2025: #Setmelanotide was associated with significant #WeightReduction among adult and pediatric patients with acquired #HypothalamicObesity.

@endocrinesociety.bsky.social @ucsdhealth.bsky.social @themaximacenter.bsky.social @sickkidsto.bsky.social @childrensphila.bsky.social

Test Your Knowledge on Nutritional Support Strategies in GLP-1 Drug Use Which of the statements about nutritional support strategies for patients using GLP-1 drugs are correct?

Quiz Time! Test your knowledge on #nutritional support strategies in #GLP1 use. #EndoSky

American Diabetes Association Archives Presenting research from the annual meeting of the American Diabetes Association.

Looking to catch up on research from #ADASciSessions? Check out Endocrinology Advisor's coverage below ⬇️
#ADA2025 #EndoSky #MedSky @amdiabetesassn.bsky.social

Early Abdominal CT Without Prior Indication May Detect Adrenal Mass Early abdominal CT may be warranted among patients with unknown or uncertain biochemical screening results for primary aldosteronism.

One in 14 patients screened for #PrimaryAldosteronism without prior #adrenal imaging had an adrenal mass.

@ucalgarymed.bsky.social @caldommed.bsky.social @dalhousieu.bsky.social @ubcmedicine.bsky.social @abhealthservices.bsky.social

MASLD Rates Decreasing, Fibrosis and Cirrhosis Rates Increasing in T2D in US MASLD rates have decreased, whereas liver fibrosis and cirrhosis rates have increased among US patients with type 2 diabetes since 2017.

The prevalence of #MASLD has decreased, whereas the prevalence of #LiverFibrosis and #cirrhosis have increased among US patients with #T2D since 2017.

@endocrinesociety.bsky.social

Diabetes Remission More Likely in Women vs Men With PPGLs Diabetes remission was more likely and laparoscopic surgery was less likely among women than men with paragangliomas and pheochromocytomas.

Compared with men, women with #pheochromocytomas and #paragangliomas were less likely to undergo laparoscopic surgery and more likely to achieve #diabetes remission.

@ki.se

LT4 Plus T3 Therapy Reduces Dementia, Mortality Risks in Hypothyroidism LT4 plus L3 therapy vs LT4 therapy alone was associated with reduced mortality and dementia risks among patients with hypothyroidism.

Addition of T3 to LT4 therapy may reduce the heightened risks for mortality and #dementia associated with #hypothyroidism.

@utmbhealth.bsky.social @uspoficial.bsky.social