Dan Nasko

Electron micrograph of two phage infecting a host cell side-by-side, with hearts between them

Do you love phage? I have an opening for a postdoc in my lab at the University of South Florida College of Marine Science (@cmarinescience.bsky.social) looking at interactions between marine phage and iron, which is an important limiting trace metal in the oceans (1/5) 🧵#phagesky 🦠🌊

A Tipping Point For Science and Society To confront attacks on experts, expertise, and the rule of law, we must recommit to supporting an independent science and medical research infrastructure.

Today's large-scale termination of grants building on months of attacks on experts, expertise, data, and programs reveal the essence of this administration's priorities: dismantling America's innovation-driven economy.

We face a tipping point for science & society.
substack.com/home/post/p-...

Great talk today by @treangen.bsky.social from Rice University on the advantages of @pacbio.bsky.social #longread #hifi for #microbiome and #metagenomics research + assembly of the great horned owl.

After stops in Danang and Athens, the #PacBioPRISM global tour has arrived in San Francisco! 🇺🇸

We kicked off Day 1 with 25 years of #PacBio innovation and a powerful keynote from Sean Baumstark on resilience, purpose & living beyond limits. We’re just getting started!

It’s the last day for the booths at #APHL! Be sure to come see @pacbio.bsky.social and chat about our new Vega bentchtop sequencer, bringing high accuracy long reads to your public health endeavors. #longreads #microbiology #microbiome #metagenomics

Berry Genomics is transforming single-gene disorder testing in China with #HiFisequencing. Their Thalassemia assay has boosted diagnosis rates and is now powered by the #Vega system.

Read the full story: bit.ly/4iOussj

#PacBio #ClinicalGenomics

Emily Farrow from Children’s Mercy Hospital is the first speaker on day 2 of @pacbio.bsky.social PRISM SF.

Complex structural variant visualization with SVTopo Structural variants are genomic variants that impact at least 50 nucleotides and can play major roles in diversity and human health. Many structural variants are complex multi-breakpoint rearrangement...

I just released a new preprint! The manuscript describes SVTopo, a software tool that enhances visualization of complex SVs using HiFi data: www.biorxiv.org/content/10.1.... Here’s a summary of the results:

Exciting things ahead at #AACR25! Join the #PacBio spotlight session to see how long-read sequencing is unlocking cancer variants missed by other technologies. Don’t miss out on this chance to explore the future of cancer genomics.


Details: bit.ly/4icu5rh

Sawfish: Improving long-read structural variant discovery and genotyping with local haplotype modeling AbstractMotivation. Structural variants (SVs) play an important role in evolutionary and functional genomics but are challenging to characterize. High-accu

Great to see that sawfish, our new HiFi SV caller, is accepted for publication in Bioinformatics! Sawfish emphasizes local haplotype modeling to improve SV representation and genotyping in both single and joint-sample analysis. Advance-access article now available: (1/n)

doi.org/10.1093/bioi...

Come and meet the @pacbio.bsky.social team and #Vega at @microbiologysociety.org conference! #microbio25

Will be attending #ACMGMtg25 this week, would love to talk to anyone interested in long-read sequencing analyses!

Winston Churchill at the White House wearing a one-piece garment known as a siren suit.

Zelenskyy's character can be judge more directly by how he treats others and whether you think he's protected his country. From what I've seen, he has treated Americans with respect. His attire is to remind people he's at war, not unlike Churchill wearing a siren suit to the White House in 1942.

Man in a suit, dress shirt, and tie. Women are rubbing themselves against him.

Man on a horse wearing Filson gear. He looks rugged and is surrounded by mountains.

Many people are unable to separate clothes from character, which is how the fashion industry makes so much money. They sell you on the idea that you can be a certain person by wearing certain clothes. In reality, character is defined by actions, not clothes.

Drawing of Benjamin Frankling wearing a coonskin cap.

Franklin being received by the French court in 1778. The French are in powdered wigs.

FWIW, it's perhaps worth noting that when Benjamin Franklin visited France between 1776 and 1778 to ask for military support for the then-new-formed United States of America, he wore a coonskin cap. "Proper" French court attire at this time was a powdered wig.

Two photos: One shows Zelenskyy in a black quarter zip at the White House meeting, the other shows Elon Musk in a black graphic t-shirt, black topcoat, and black ball cap, also meeting with the Trump cabinet.

One reason why I think respectability is stupid is because it's often used as a mask. Such judgements are rarely about the clothes themselves, but more often about the bodies beneath them. To wit, no one raised an issue when Elon wore a graphic t-shirt and ball cap to meet the Trump cabinet.

Join #PacBio for A Bright New Day at PAG 2025! Celebrate discoveries driving plant and animal genomics with live music, dinner, cocktails, and networking. Registration and a PAG conference badge are required for entry. 

Register: bit.ly/41DahZl 

#PAG32 

Greenland shark with “I am not a toy, I am a 400 year commitment” text

Think carefully before buying a Greenland shark for the holidays. They are, after all, the world’s longest-living vertebrate.

Turkey derrick setup complete ✅
Mishka guarding the turkeys ✅

@sedlazeck.bsky.social AMPath24 talk about long reads highlighting TRGT tool by @egor-dolzhenko.bsky.social and @guilhermesena1.bsky.social and others for HiFi sequencing by @pacbio.bsky.social

a man in a suit is standing in a living room in front of a reel to reel tape recorder . ALT: a man in a suit is standing in a living room in front of a reel to reel tape recorder .

Find yourself looking for an affordable, reliable, and highly accurate #longread benchtop sequencer? Look no further with Vega 🕺. It's perfect for #microbial genomics applications like #microbiome, #metagenomics, full-length #16S, isolate #WGS, and #viral seq. @pacbio.bsky.social
www.pacb.com/vega/

If you were interested but missed it: www.pacb.com/wp-content/u...

We can see there's already excitement for Vega on Bluesky. ✨ What do you think about the first #PacBio HiFi benchtop system?

This goes hard.

I'm hiring a Senior Software Engineer at PacBio with focus on improving & productizing ML algorithms. You can work remotely from Europe / USA, or local in Menlo Park.

This is a one time chance to join the long-read bioinformatics instrument team.

www.linkedin.com/jobs/view/37...