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⚡ This cycle is mechanosensitive & calcium-driven.
Chromatin compaction is triggered by Ca²⁺ and mechanics. Chromatin rewetting is associated to a Ca²⁺ spark, fueling nuclear + cytoskeletal changes, JNK activation, and actin ring formation.
Check out the videos!
23.09.2025 15:40 — 👍 0 🔁 0 💬 0 📌 0
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
23.09.2025 15:40 — 👍 15 🔁 4 💬 1 📌 1
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