@rbdamgaard.bsky.social
Associate Professor, Section for Medical Biotechnology, Technical University of Denmark. Studies ubiquitin signalling in inflammation, metabolism, and disease.
🚨 Postdoc position in my lab!
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
🚨 Postdoc position in my lab!
A project on protein binder discovery for K6-linked #ubiquitin to investigate their role in infection is available.
📍 DTU, Copenhagen, Denmark
⏰ Deadline: 18 December 2025
Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
A #postdoc position in atypical #ubiquitin signalling and protein binder engineering is opening soon in my lab at DTU Bioengineering! Get in touch if you are interested.
30.10.2025 14:13 — 👍 6 🔁 3 💬 0 📌 1
🚀 Off to our Research Retreat with the Section for Medical Biotechnology, DTU Biotechnology and Biomedicine.
Two days of science, ideas & innovation 🧬💡
12 faculty pitches, 30+ PhDs & postdocs, and endless opportunities for new collaborations 🔬🤝✨
A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!
chemistry-europe.onlinelibrary.wiley.com/doi/full/10....
Hope this serves as a useful overview for anyone working on ubiquitin signalling or PTMs. Big thanks to those who did the heavy lifting in the writing process: Julian Koch, Camilla Reiter Elbæk & @dompri.bsky.social 🙌😊
16.09.2025 07:45 — 👍 0 🔁 0 💬 0 📌 0We also highlight:
✅ Trade-offs between specificity, throughput, & sensitivity
✅ Gaps in the current toolbox where innovation is needed
✅ The value of combining orthogonal methods for robust insight
…alongside analytical platforms such as:
✅ Immunoblotting 🧫📊
✅ Fluorescence microscopy 🔬🌈
✅ Enzymatic assays 🧪⏱️
✅ Mass spectrometry ⚡📈
In the review, we summarise state-of-the-art tools for probing linkage-type specificity:
🎯 Antibodies & antibody-like molecules
🎯 Affimers
🎯 Engineered Ub-binding domains
🎯 Catalytically inactive deubiquitinases
🎯 Macrocyclic peptides
Why this matters ⬇️
Ubiquitin chain diversity, i.e. different linkage types, mixed or branched chains, is central to cell signalling.
But analysing these chain types specifically remains a big challenge.
A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!
chemistry-europe.onlinelibrary.wiley.com/doi/full/10....
Is it still useful to insist that authors spell out every protein name in research papers? Many names are long, obscure, and say nothing about function... we might as well call them James, Joan, and John.
14.08.2025 12:09 — 👍 3 🔁 0 💬 0 📌 0The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
13.08.2025 17:28 — 👍 335 🔁 87 💬 4 📌 5
Jeg er godt træt af måden regeringens spareplan rammer universiteterne.
03.07.2025 10:33 — 👍 3 🔁 1 💬 0 📌 1the really key number to remember is that biorxiv serves the entire global science community, posting thousands of papers per month for millions of readers, and it's entire running costs ( a few $M/year) are less than some single labs....
02.07.2025 18:27 — 👍 43 🔁 15 💬 2 📌 2it’s a global contest, whether we want to compete or watch from the sidelines
23.05.2025 16:23 — 👍 239 🔁 95 💬 12 📌 5
Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.
16.05.2025 18:35 — 👍 15 🔁 6 💬 1 📌 0
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
Congrats!!
13.05.2025 20:48 — 👍 1 🔁 0 💬 0 📌 0Haven’t shared this in a while. But the #ubiquitin and #ubl Starter Pack now includes 116 profiles to follow if you’re interested in the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.
13.05.2025 10:04 — 👍 14 🔁 5 💬 0 📌 0
Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.
22.04.2025 11:31 — 👍 31 🔁 9 💬 1 📌 0
Our review is published alongside a long list of other excellent reviews in a special issue of ChemBioChem (chemistry-europe.onlinelibrary.wiley.com/doi/toc/10.1... edited by @jnpruneda.bsky.social and Monique Mulder. Thanks a lot for the invitation to contribute to this fantastic issue.
22.04.2025 11:31 — 👍 5 🔁 2 💬 0 📌 0
Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.
22.04.2025 11:31 — 👍 31 🔁 9 💬 1 📌 0Congratulations, Elton and team!
18.03.2025 08:04 — 👍 1 🔁 0 💬 1 📌 0Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
Lungfish xkcd.com/3064
17.03.2025 16:53 — 👍 11964 🔁 1315 💬 96 📌 88Nysgerrighedsdrevet, uafhængig forskning er en samfundssøjle - i disse tider er det mere tydeligt end nogensinde. Og EU har en særlig vigtig rolle.
05.03.2025 09:04 — 👍 7 🔁 4 💬 0 📌 1Ny kronik fra DUA i Dagbladet Information på baggrund af de verserende rygter om at ville indføre større politisk styring og strategisk prioritering af midlerne i ERC.
04.03.2025 19:35 — 👍 8 🔁 8 💬 0 📌 0
European Research Council må ikke blive udvandet ifm forhandlingerne om EU’s forskningsbudget. ERC skal forblive en uafhængig enhed, der investerer i nysgerrighedsdreven forskning - for det er grundlaget for de nye indsigter, der driver vores samfund fremad. www.information.dk/debat/2025/0...
05.03.2025 08:27 — 👍 13 🔁 5 💬 0 📌 1
