Álvaro López Codina

Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC Xie et al. demonstrate that IRTKS forms liquid-like droplets on lysosomes, which may regulate mTORC1 activity through selective interaction with the GTPase RRAGD. IRTKS overexpression hyperactivates mTORC1 downstream signaling and initiates a cascade from metabolic liver diseases to liver cancer, thereby representing a potential therapeutic target.

Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC

Structural and regulatory principles underlying apicomplexan conoid function pubmed.ncbi.nlm.nih.gov/41654468/ #cryoEM

AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis - Nature Metabolism In this Review, Smith et al. summarize the most recent findings on AMPK and emphasize its role as a nutrient sensor and in regulating metabolic homeostasis, as well as how AMPK dysregulation contributes to various diseases.

#Throwback 🧪

REVIEW | AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis

MD Fullerton, GR Steinberg et al

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the…

My PhD work is finally out! Huge thanks to all the collaborators who made this possible 🎉
Looking forward to the next chapter as a postdoc 😁
www.sciencedirect.com/science/arti...

The G3BP stress-granule proteins reinforce the integrated stress response translation programme - Nature Cell Biology Smith and Bartel show that mRNA recruitment to stress granules imparts resistance to the integrated stress response translational shutdown.

☕Smith and Bartel show that #mRNA recruitment to #StressGranules imparts resistance to the integrated stress response translational shutdown.
bit.ly/45WSNbP

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

☕ @allanaschooley.bsky.social @jobdekker.bsky.social & co find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
bit.ly/4r6uO2D

Modeling of the ER-Golgi SNARE assembly complex

Ionna, I don't know if you saw our papers on Sly1 last year. You might particularly like the second one, which presents evidence that a Qa (Sed5) Habc domain is part of the core SM-SNARE assembly complex. Hope your current work is going well!

rupress.org/jcb/article-...
rupress.org/jcb/article-...

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration Iu et al. uncover a Ca2+ signaling pathway promoting cell migration by facilitating actin assembly in protrusions. Ca2+ influx through TRPV4 channel activates RhoA in lamellipodia via CaMKII and TEM4,...

A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration: Current Biology www.cell.com/current-biol...

Coordinating mRNA maturation: The U1 relay model Yoon et al. provide a broad overview of how all the RNA processing steps are intimately linked to transcription and to one another. They propose a U1 relay model as a general framework for understanding the mechanism for coupling transcription and RNA processing.

Coordinating mRNA maturation: The U1 relay model

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

Pol γ possesses separate metal binding sites for polymerase and strand displacement functions pubmed.ncbi.nlm.nih.gov/41648309/ #cryoEM

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1 pubmed.ncbi.nlm.nih.gov/41648251/ #cryoEM

Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B pubmed.ncbi.nlm.nih.gov/41648189/ #cryoEM

Histone Fold mediated heterodimerization specifies the selective association of TAF12 paralogs with TFIID and SAGA complexes in Candida albicans. https://www.biorxiv.org/content/10.64898/2026.02.06.704445v1

Fully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/41648103/ #cryoEM

Mechanism of substrate recognition and catalysis in a mammalian phosphatidylserine synthase 2 https://www.biorxiv.org/content/10.64898/2026.02.06.704487v1

The kinetics of ribonucleoprotein granules https://www.biorxiv.org/content/10.64898/2026.02.04.703460v1

Point transformer for protein structural heterogeneity analysis using CryoEM pubmed.ncbi.nlm.nih.gov/41647221/ #cryoEM

Snapshots of Internal Protein Crystal Architecture at the Nanoscale pubmed.ncbi.nlm.nih.gov/41648623/ #cryoEM

Gradient based refinement of CryoET tilt series alignment improves tomogram contrast and structure resolution pubmed.ncbi.nlm.nih.gov/41648511/ #cryoEM

www.biorxiv.org/content/10.6...

Check this from

@patrickbryant1.bsky.social

An SPFH Protein Couples Membrane Stress to Differentiation in Bacillus subtilis https://www.biorxiv.org/content/10.64898/2026.02.06.704340v1

www.nature.com/articles/s41...

Incredible new work on ciliary axoneme assembly spearheaded by @helenfoster.bsky.social (#NewPI) from the @gaiapigino.bsky.social. Like all good science, answers many questions & opens up many new ones!

Kudos to the entire team for this important advance in cilia biology. Lovely animation!

All lights on protein folding 💡

Out @nature.com , @niko-dalheimer.bsky.social & @rongqinxiaoxiao.bsky.social from the Hartl lab at @maxplanck.de Institute of Biochemistry developed single-particle tracking in living cells to study the dynamics of co-translational protein folding

#sciart #scicomm

Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Lawrence et al. examine how ribosome production in the eukaryotic nucleolus is coordinated by cytoplasmic processes to maintain appropriate ribosome numbers. The authors highlight regulatory inputs from cytoplasmic signaling, mitosis, and cytoplasmic organelles that converge on nucleolar function, and they discuss how disruption of these pathways contributes to human disease.

Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus

Structural biology of ferritin nanocages pubmed.ncbi.nlm.nih.gov/41649052/ #cryoEM

DNA translocation by the CMG helicase: the helical inchworm model pubmed.ncbi.nlm.nih.gov/41649037/ #cryoEM

RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions Kretov et al. introduce RBPscan, an RNA-editing-based platform that measures how RNA-binding proteins engage their targets in living cells. This approach quantifies the binding strength of protein-RNA...

www.cell.com/molecular-ce...

Quantitative Stimulated Emission Depletion (STED) Microscopy with DNA-Fluorophore Labels Stimulated emission depletion (STED) microscopy enables super-resolution imaging of complex biological samples in 3D, in large volumes, and live. However, molecular quantification with STED has remain...

pubs.acs.org/doi/10.1021/...