Easy Electrophysiology

Datashuttle automatically creates and validates formatted folder trees for data storage.

It also provides data transfer between machines. Thanks to standardization, it is easy to transfer specific subsets of data (e.g., only the test sessions)!

datashuttle.neuroinformatics.dev/index.html

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A lack of standardization can cause major headaches. Have you ever spent hours trying to make sense of how a colleague (or your past self) organized a dataset?

Datashuttle implements the NeuroBlueprint format to align projects across researchers
neuroblueprint.neuroinformatics.dev/latest/index...

Cross-posting a useful tool to help keep your neuroscience projects organized!

Datashuttle is a neat Python tool (with a graphical interface) that automates folder creation and data transfer.

Website: datashuttle.neuroinformatics.dev
Chat: neuroinformatics.zulipchat.com#narrow/chann...

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Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!

Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.

Sharing appreciated, and happy #FluorescenceFriday !

Today's #TraceTuesday also comes from Nic! This trace shows action potentials (spikes) from a retinal ganglion cell. Notice how the activity is much more slow compared to the cell from Adam a few weeks ago! 📈

Happy #MicroscopyMonday everyone! 🔬🧪 Today we have something a little bit different by Nic! In the video we can see the process she uses to clean the cells in order to patch them. 🐀

No #FluorescenceFriday, just sped up action potentials 🚀🧠🧪

Today's #TraceTuesday comes from Adam! It shows a mature intrinsic lateral olivocochlear neuron (iLOC; a type of efferent neuron) firing lots of action potentials! These iLOCs contact with the type I afferent neurons that innervate the inner hair cells, but not much is known about them. 📈🧪

A microscope with dozens of cables emerging from every location.

Cable management is my passion 😎

Quite a nice image of 5-HT2A receptor distribution by Blake in the lab using our mice (I think now at JAX)

pubmed.ncbi.nlm.nih.gov/37808655/

Starting things off today, we have a trace from Ivy, who is currently getting to grips with the art of patch-clamping! This trace shows the mechanoelectrical transduction (MET) current from a neonatal mouse outer hair cell. This is a great achievement for Ivy 🎉.

Great idea! Will be following these 👀

Join us for the next SGP EpIC Seminar on Tuesday, 5 May, at 12:00 pm Eastern featuring a talk by Amanda Lewis, "Piezo1 ion channels are capable of conformational signaling." As ever, registration is free and all are welcome. sgp-epic-seminars.com

Biocytin-filled neuron obtained from cortical tissue of a 10-year-old child.

#Patch clamp_electrophysiology
#Human tissue

Confocal micrograph

My mom used to love #FluorescenceFriday, so I will keep posting in her memory ❤️

This photo shows neurons in the hippocampus accumulating phospho-tau in our monkey model of Alzheimer's Disease.

Markers: Dapi 🔵, Neun 🔴, pTau 422🟣, AT8🟡

Lots of spiking cells today, life is good 😎🧠🧪

As a journalism grad, I struggled with Git for YEARS. For longer than I’d like to admit, it felt easier to keep my code on Google Drive instead of GitHub. 😅

So I’m kicking off a new section on Code Like a Journalist all about Git and GitHub!

First lesson linked below — with more on the way! 👇

Live-streaming patch clamp for education outreach, great idea!

RichardSmithLab - Twitch Whole Cell Patch Clamp with Smith lab

Labs going live with patch clamp experiments to introduce Chicago teachers to collaborate in the high school classroom. www.twitch.tv/richardsmith...

We are looking for an outstanding postdoctoral researcher to join our team at McGill University. The Sjöström lab studies neocortical circuits, with a focus on synaptic plasticity, NMDA receptor signaling, 2-photon optogenetics, and advanced 2-photon imaging. We are particularly interested in candidates with strong expertise in whole-cell patch-clamp electrophysiology and/or 2-photon imaging, and a solid track record of relevant publications. Applicants should be experienced with whole-cell recordings and/or cutting-edge imaging approaches. Responsibilities will include performing experiments, analyzing and presenting data locally and internationally, writing manuscripts, and occasionally mentoring junior lab members. Our lab is based at the Research Institute of the McGill University Health Centre, in vibrant, multicultural Montreal—a city that offers exceptional quality of life. McGill and its neighbouring universities form one of the most dynamic neuroscience communities in the world. For examples of our current directions, see: • Chou et al The Innovation 2025, www.cell.com/the-innovation/fulltext/S2666-6758(24)00173-5 • Wong et al Neuron 2024, www.cell.com/neuron/fulltext/S0896-6273(23)00767-5 The position is fully funded with a competitive salary. Candidates are also expected to apply for external funding, for which we provide strong support. Opportunities are available for both Canadian and international applicants. To apply, please send a Letter of Intent, CV, brief research statement, and contact information for three referees to Dr. Jesper Sjöström (jesper.sjostrom@mcgill.ca). In the subject line, include "Postdoc" followed by your name. Application deadline: July 31, 2025. Website: http://plasticity.muhc.mcgill.ca McGill University is committed to diversity and equity in employment.

🧪 The Sjöström Lab in Montreal is looking for a postdoc! We study cortical circuits, synaptic plasticity, and NMDAR signalling using custom 2-photon microscopy and optogenetics. We seek candidates with strong patch-clamp and/or 2-photon imaging expertise, and a relevant publication track record.

📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏

A rig for slice patch clamp electrophysiology.

The lab is ready for slice electrophysiology after a four-year hiatus.

The rig is working again! 👏

It's that time of year again! Apply now for the fantastic Cell Physiology Workshop (August 2025, Liverpool, UK)

Physiology & #neuroskyence trainees!

Enhance your electrophysiology theory & lab skills on various techniques including patch clamp.
🧪⚡🧠🧬❤️🔬 #ionchannels

Cell Physiology Workshop 11th-22nd August 2025, Liverpool UK.
Apply by 14th April:
www.liverpool.ac.uk/life-course-...

Please repost 🙂

We are recruiting!!
If you are looking for a post-doc (ephys, slice imaging) or a PhD position (molecular neuroscience), are interested in Axon Initial Segment plasticity and want to join a nice team in a great environment, have a look!
And, that's us 👇

Not original, apparently, but here was my patch clamp starter list. I have a long way to go, please hit me up to be added.

bsky.app/profile/did:...

V2.8.0 is out! 🎉 It includes improved plotting features, a new subsample events window, and many additions and improvements. Download from www.easyelectrophysiology.com