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Steve Middleton

@middletonsj.bsky.social

Post Doc • Bennett Lab • Pain and Sensory Biology • Research Fellow, @WolfsonCollege • University of Oxford • 🏳️‍🌈

54 Followers  |  97 Following  |  2 Posts  |  Joined: 20.03.2025  |  1.5319

Latest posts by middletonsj.bsky.social on Bluesky

Massive thanks to everyone involved! Especially, the Bennett group @ndcnoxford.bsky.social and the Newstead team @kavlioxford.bsky.social @oxfordbiochemistry.bsky.social. Big shout out to my co-first author @sigurbjornm.bsky.social!

21.08.2025 12:20 — 👍 2    🔁 0    💬 0    📌 0
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SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!

www.nature.com/articles/s41...

21.08.2025 12:16 — 👍 81    🔁 26    💬 4    📌 0
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SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!

21.08.2025 11:05 — 👍 17    🔁 7    💬 1    📌 0
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📣 NEW: Breakthrough discovery of a genetic link to pain co-led by NDCN's Prof David Bennett and Prof Simon Newstead @oxfordbiochemistry.bsky.social

The results of the research, published in @nature.com, could lead to a promising new target for the treatment of #chronicpain.

21.08.2025 11:11 — 👍 5    🔁 1    💬 1    📌 1

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