Sergiu P. Pasca

This looks like an impressive symposium on #organoids (h/t @sergiuppasca.bsky.social)
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html

A clever forebrain assembloid model! Congratulations!

Link here: www.annualreviews.org/content/jour...

Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience

With the great @rebeccalevymdphd.bsky.social

Midline assembloids reveal regulators of human axon guidance Organizers orchestrate cell patterning and axon guidance in the developing nervous system. Although nonhuman models have led to fundamental discoveries about floor plate (FP)–mediated midline organiza...

Article here: www.science.org/doi/10.1126/...

This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators.

A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video above).

This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells.

Our latest work is out today in @science.org: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development.

Work led by Massimo Onesto with Neal Amin in the lab

PSIDER NETWORKING MEETING: IPSC-DRIVEN THERAPEUTIC INNOVATION FOR BRAIN DISORDERS Joint meeting of the ZonMW PSIDER consortia ​ This year we organize a joint meeting of the ZonMW PSIDER consortia TAILORED and BRAINmodel, two large scientific consortia supported by ZonMW.  We...

🧠 Join us in Rotterdam for a one-day meeting focused on iPSC-Driven Therapeutic Innovation for Brain Disorders!

We’re thrilled to announce our keynote speaker @sergiuppasca.bsky.social

📅 Event date: September 19, 2025
📍 Location: Erasmus MC Rotterdam
🔗 Register now: www.neurodevdisorders.org

Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

Model organism communities are fantastic. Good work, "Drosophilists"! www.nature.com/articles/d41...

YouTube video by Yuki Miura XG prep

and a short video made by Yuki to show how to dissolve the xantham gum: www.youtube.com/shorts/hoS4e...

Scalable production of human cortical organoids using a biocompatible polymer - Nature Biomedical Engineering Addition of an inexpensive, biocompatible polymer reduces spontaneous fusions of organoids in culture.

Article here: nature.com/articles/s41...

#Organoids #StemCells #DrugScreening #Neurodevelopment #TranslationalResearch

Hoping that will be one more step toward scalable human models for brain development and drug discovery.

This enabled a single experimenter to screen all FDA-approved drugs for neuropsychiatric disorders across 2,400 organoids, identifying compounds that impair human cortical development.

In brief, this is done by simply adding the cheap food additive xantham gum!

Sharing today the latest from our lab, just published in Nature Biomedical Engineering.

As stem cell models gain traction for disease modeling and drug testing, one of the bottlenecks has been scaling up production. In work led by Yuki and Genta, we present a simple and cost-effective solution.

sto.stanfordtickets.org/ethical-and-...

Strong interest already in the upcoming Asilomar meeting on the ethical and societal implications of human neural #organoids, #assembloids, and their transplantation.

Just 10 days left to apply—details at the link below.

This should be an excellent, and (we hope) important meeting. Join us!

Participation will be limited.
Apply here before July 20 to join us:
sto.stanfordtickets.org/ethical-and-...

#Organoids #Assembloids #Neuroscience #Bioethics #ScienceAndSociety #Asilomar2026

This meeting supported by the Dana Foundation and the Stanford Brain Organogenesis Center will bring together scientists, ethicists, patient advocates, and science communicators for an open conversation.

Grateful to have such an extraordinary group joining us 👇

Excited to announce that applications are open for the Asilomar meeting on The Ethical and Societal Implications of Neural Organoids, Assembloids, and Their Transplantation!

As the technologies & applications of 3D neural models evolve, a number of ethical and societal issues are emerging.

Thrilled to introduce the newest PhD from the lab—Dr. Massimo Onesto—who successfully defended his thesis @stanfordmedicine.bsky.social.

An exciting day for an exceptional scientist!

Behind is the now-traditional “assembloids cake” we put together for the occasion.

Congratulations, Massimo!

Looking forward to a thought-provoking session today at @isscr.org in Hong Kong—discussing emerging ethical questions around neural #organoids, #assembloids, and their transplantation. Join us at 2 PM in Hall 3G.

YouTube video by StarTalk Groundbreaking Studies Recreate Human Brain Circuits in a Dish

A few weeks ago, I talked to @neildegrassetyson.com on his StarTalk Radio about our efforts to understand human brain disorders with stem cell models including #assembloids. We touched on the promise of these technologies, the challenges & the mission behind the work

www.youtube.com/watch?v=HEBj...

Article, open access, here: www.nature.com/articles/s41...

Over the past couple of weeks, several asked if I could share the individual slides summarizing our recently published framework in @nature.com on designing experiments with #organoids, #assembloids, and transplantation. Here they are—6 slides capturing the key takeaways👇