Tom Riffelmacher

A bit like spiralling publication costs we need to start having a proper discussion around lab equipment servicing costs. These are often completely disproportionate to the cost of instrument and the service that is provided and seem to serve as a cash cow for vendors.

Awesome science creativity podcast
@nightsciencepod.bsky.social

Review @natrevimmunol.nature.com
Metabolic control of innate-like T cells
www.nature.com/articles/s41...

"Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology."

LJI experts share key discoveries from the growing field of immunometabolism! 👇 #Tcells #Cd1Mr12025

Metabolic control of innate-like T cells - Nature Reviews Immunology Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...

Just in time for #Cd1Mr12025

Our Review on Innate-like T cell Metabolism is out!

Access free here: rdcu.be/eEV67

Please share with your Immunometabolism friends!

@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com

Horisberger et al separate Lupus nephritis patients in 3 groups by blood:
healthy-like, interferon-dominant and CD8 T cell-dominant.
The CD8 T cell-dominant group had the highest biopsy activity score and highest response rate after 1 year; the healthy-like the most chronic damage. 🧪 ⑂ #NephSky
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In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.

First session featuring our DGfI study groups ✅ covering innate immunity, autoimmunity, solid tumor immunology, trained immunity and CNS. Much food for thought and discussion during the coffee break☕☕☕ #IUIS25 @dgfi-org.bsky.social

Good luck with the startup!

Bittersweet farewell weeks at @kiroxford.bsky.social, a place pivotal to my growth as an independent scientist. With deep gratitude for this chapter, I'm thrilled to begin the next at @unibas.ch @biomedizin.unibas.ch, where my lab will study organelle inheritance in T cells in the context of ageing.

MTA/BTA Stelle zu besetzen bei uns im lab! Join us!

In diabetic retinopathy, microvascular damage & inflammation disrupt the blood-retina barrier, but the role of microglia was unclear

Thomas Langmann & team now show suppression of microglia-driven inflammatory responses preserves retinal integrity.

buff.ly/2k5pD5W

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Same! solving IT “issues”, like accessing university email, are my small daily wins in those days

Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD Mucosal-associated invariant T (MAIT) cells constitute a highly abundant innate-like T cell population in the human liver that is critical for immune surveillance of hepatic cancers but often dysfunct...

Very cool!

www.journal-of-hepatology.eu/article/S016...

Forget Trump & Musk's bromance...join us at Keystone's Immunometabolism Across Scales: From Cells to Systems to Healthspan!
Super science, discussions and colleagues. Be there- Vancouver, BC Jan 11-14, 2026. Keynotes: Amazing Drs. Dana Pe'er and Marcia Haigis!! Speaker line-up is GOAT!

Openness guides discovery

MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset of innate-like T cells with features of both Th1 and Th17 lineages, are increasingly recognized for their roles in mucosal immunity. Here, we identified the Collaborative-Cross CC011/Unc strain, which spontaneously develops chronic colitis, as being enriched for MAIT cells. This expansion coincides with an age-related loss of intestinal barrier permeability and colonic inflammation.

Nice paper, out today!

We also see a surge of postdoc applications of highly qualified scientist who normally would pursue their work in the US

Thank you! Sad that I missed your talk on wednesday.

A huge congratulations to LJI's Dr. Tom Riffelmacher! Tom's work has helped reveal a whole new side of T cells, and we are thrilled to see what he does next! 🎉

With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive

Thanks, Reika :) I will miss @lji.org

I am not dreaming, it’s official! I am starting my lab as Professor in the department of medicine III at @unicologne.bsky.social
We will explore the immunometabolic control of unconventional lymphocytes in cancer and cardiovascular disease.
WE ARE HIRING AT ALL LEVELS (MTA/BTA, postdoc, PHD)

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

It’s done 😮

The Professional Self: The Enemy Inside

I'd like to share this short piece on a topic I hope you will find useful. It is the result of a personl journey and many discussions with friends and peers. Let me know your thoughts.

network.febs.org/posts/the-pr...

I am honored to be part of the Gates foundation research consortium on unconventional T cells and grateful for their support.

Great time catching up with friends from near and far, and making new ones at HawAAI #AAI2025 #IMMUNOLOGY2025

HawAAI 2025 in full swing. DM me if you are here and want to catch up or get to know each other! #AAI2025 #Immunology2025 #MAIT #immunometabolism 🌺

Can't make it to #IMMUNOLOGY2025?

Brenda and Jason will be recording from Honolulu to keep you up to date!🎙️

Our first daily episode will be released on May 4. Stay tuned!

#AAI2025