Jacob Wolfe

It's the American Peptide Society Conference, this character limit is rough.
aps2025.org

Excited to present a flash talk and poster at the APS 2025 Conference!

🎤Flash Talk Info
📅 Date: Sunday, June 15, 2025
⏰ Time: 1:00 PM - 3:45 PM PST (Exact 10 min Slot, TBA)

🖼️ Poster Number P-047, Poster Session 1
📅 Date: Monday, June 16, 2025
⏰ Time: 12:30 PM - 2:00 PM PST

#ChemSky #PCJC

Streamlined Identification of Metallopeptides for Intracellular Catalysis Using Positionally Addressable Combinatorial Libraries The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface of Chemistry and Biology. Current approaches rely on time-...

We're excited to share our latest paper, just accepted in ACS Catalysis! 🎉 in which we describe how positionally addressable peptide libraries (SPOT libraries) can be used to discover artificial metallopeptide catalysts that work inside living cells. 👇 #ChemSky

pubs.acs.org/doi/full/10....

#ChemSky #PCJC #Peptide #AcademicSky #BioSky

Started a LinkedIn newsletter aggregating the titles of peptide papers for anyone who wants to stay up to date on the literature

Link to Article - www.linkedin.com/pulse/202504...

Not to shamelessly self-promote, but this first article in the series goes into a little more depth on the topic. It's cited in the new one but I'll leave it here too 🙂https://www.linkedin.com/pulse/alphafold3-best-practices-how-analyze-interpret-af3-jacob-wolfe-5eute

LinkedIn Article Title: Alpha Fold 3 Best Practices - How to Confidently Present an AF3 Structure (With Code!) The image is a two panel, on the left is a bar graph displaying triplicate mean and standard deviation values from 3 independent AlphaFold refolding simulations for the protein GB1, it's reversed sequence, and a scrambled sequence. On the right shows 4 ChimeraX visualizations of the models from that analysis. The original crystal structure 1PGA is color coded grey, other 3 models (GB1, Reversed, and Scramble) are color coded by Ca pLDDT scores. The reversed and scramble sequences have much lower scores.

I have been writing a series of LinkedIn articles summarizing #AlphaFold 3 best practices. Hopefully they're a good resource for everyone on here too.

Link to New Article- www.linkedin.com/pulse/alphaf...

#BioSky #Chemsky #PharmaSky #ProteinDesign #StructuralBiology #Biochemistry

Really feels like De Novo Miniprotein bunders are the future of peptide therapeutics #BioSky #MedSky #ChemSky

H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration - Communications Medicine Bernardo-Colón et al. evaluate small peptides derived from the neurotrophic region of pigment epithelium-derived factor (PEDF) as potential therapeutics for retinitis pigmentosa using mouse models and...

👁️💧 NEW RESEARCH!

Kernardo- Colón et al. prevent vision loss in mice and human retinal cells using the small peptide H105A in eye drops to promote photoreceptor survival in the eye.

#Medsky #academicsky 🩺⚕️👀

Read more here: www.nature.com/articles/s43...

Green chemistry doesn't get the love it deserves. With more peptide drugs being developed every day, it's great to see researchers working to make that process more sustainable!

#ChemSky #BioSky

Miniprotein Design: Past, Present, and Prospects ConspectusThe design and study of miniproteins, that is, polypeptide chains <40 amino acids in length that adopt defined and stable 3D structures, is resurgent. Miniproteins offer possibilities for re...

Excellent question! So the term "peptide" is defined by sequence length generally <50 aa's, regardless of structure. Miniproteins have a discreet tertiary folded structure, so they can place sidechains in 3D space more like a protein and less like a peptide flexible. pubs.acs.org/doi/full/10....

Miniproteins are a potential therapeutic modality, and multimeric mini-proteins are a clever way to obtain a high degree of structural complexity with only 30-60 amino acids. Always exciting to expand the toolkit of amino acids available to increase their thermodynamic stability! #ChemSky #BioSky

Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

The new HHS Secretary -in charge of nearly every major biomedical research funding agency in the US- was finalized today.

If you want to know how your Senators voted and adjust your vote accordingly, you can get that information here.

#NIH #CDC #NSF #AcademicSky #ChemSky

Renowned scientific integrity investigator endows fund to support fellow sleuths Microbiologist Elisabeth Bik donates $200,000 to support training, travel

Many #researchintegrity sleuths are volunteers with little financial support for their often-daunting work to uncover #scientificfraud. One of the most prominent, Elisabeth Bik, has now provided money to change that. @elisabethbik.bsky.social @science.org www.science.org/content/arti...

How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

This is the most relevant article to NIH and research cuts I’ve seen.

Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”

globalnews.ca/news/9793403...

@aclu.org @aclum.bsky.social @aclupa.org Would love to hear your thoughts

Background on Unlawful Impoundment in President Trump’s Executive Orders Impoundment—unilateral action taken by the executive branch to delay or cancel appropriations enacted into law—has always been unlawful.

#LawSky #AcademicSky Grad student here, can someone explain to me like I'm 5 years old how a researcher would pursue legal action for the illegal impoundment of funds allocated to them by congress?

Most R01 schools have good lawyers, but making the info public right now would be good

NIH slashes overhead payments for research, sparking outrage Move to cut indirect cost rate to 15% could cost universities billions of dollars

The latest from your government, brought to you by @science.org.bsky.social NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...

What's Happening Inside the NIH and NSF

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.

www.science.org/content/blog...

😆

Just thought about Steve Mayo as well www.bbe.caltech.edu/people/steph...

Happy Black History Month! I’m trying to compile a list of contemporary black chemists and I could only think of 20 off the top of my head. Drop some names please. Thank you!

Squire Booker was probably already on your list :) sites.psu.edu/sjbookerlab/...

@blackinbiophys.bsky.social If you're looking for researchers with a good social media presence (and if Biophysicists are chemists -definitely depends on who you ask)

So like, if I write something and use ChatGPT to edit it for like grammar and punctuation like I would use MicrosoftWord that's not protected?

I've run that through one of those "Is this AI generated?" checkers before and it gives a low confidence that it is

PNAS provides free access to journal content and publication fee waivers for researchers in over 120 lower-income countries, promoting inclusivity and advancing global scientific discovery. This map highlights countries in which researchers can benefit from these initiatives. Image credit: Celerate.

PNAS is committed to advancing global scientific equity.

We provide free access to journal content dating back to 1915 and waive publication fees for researchers in over 120 lower-income countries, removing barriers to knowledge and discovery. Learn more: www.pnas.org/post/update/...

Lmao, thanks Lewis! 😆 For anyone who isn't aware, there are great science communicators and science journals to follow on this app. More and more papers are open access than ever

@drdre4000.bsky.social
@compoundchem.com
@pubs.acs.org
@natureportfolio.bsky.social

Come to mind for chemistry :)