M. Eugenio Vazquez

You’re mistaken. Ozempic (and the rest of GLP-1 peptide inhibitors) are made through solid-phase peptide synthesis. Insulin is a recombinant protein made in a totally different way.

I feel like getting the dudes who demand government issued girlfriends out of the gene pool might be one of those problems that solves itself

One thing I tell people over and over and over again is just how much luck I have had in my career... plus, you know, privilege, which is a systemic boost that makes luck more likely for some. Yes, I'm good at what I do. So are a lot of other people who have not had my luck. No shame to admit it.

As a chemist, I really, really, liked his earlier work on caged Ca2+ chelators. Really beautiful and creative stuff.

A poster that reads: you can’t spell hatred without red hat accompanied by a drawing of a red hat

Everything is awful but the creativity behind some of these handmade posters gives me a glimmer of hope in humanity.

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Elements of successful NIH grant applications | PNAS Is there a formula for a competitive NIH grant application? The Serenity Prayer may provide one: "Grant me the serenity to accept the things I cann...

The core ideas are applicable to many successful proposal types for funding beyond NIH.

www.pnas.org/doi/10.1073/...

I'm sorry. As a technology writer, I'm supposed to be telling you that this bet will some day pay off, because one day we will have shoveled so many words into the word-guessing program that it wakes up and learns how to actually do the jobs it is failing spectacularly at today. This is a proposition akin to the idea that if we keep breeding horses to run faster and faster, one of them will give birth to a locomotive. Humans possess intelligence, and machines do not. The difference between a human and a word-guessing program isn't how many words the human knows. I'm sorry. I know that when we talk about "digital sovereignty," we're obliged to talk about how we can build more data-centres that we can fill up with money-losing chips from American silicon monopolists in the hopes of destroying as many jobs as possible while blowing through our clean energy goals and enshittifying as much of our potable water as possible.

Córy Doctorow with another verbal bullseye: pluralistic.net/2026/01/13/n...

Is that the one with Darth Vader at the Death Star restaurant?

A workflow diagram: Have great idea Finish project Start project Tell everyone The finish project is missed out.

Morning

we're not going to have the craigpost become this, or the other times we've had it "break character" and do commentary on the horrible era we are living through, every week.

in this nightmare, just try and do one silly post a week.

doesn't make it less true though

This view resonates deeply with me:

⬛ Publish fewer claims and more proof

Papers need to include fewer claims and more proof to make the scientific literature more reliable

What is driving today’s ‘claims inflation’?

1/3

Near the C-terminus in the right. It looks like AI crap.

Change my mind meme with the text “Strauss waltzes at the Vienna New Year’s Concert were basically 19th-century reggaeton”

🎉 Happy new year everyone!! 🎉

How do you people find time to read so many books!?!

YouTube video by CardinalSessions Iron & Wine - Song in Stone - CARDINAL SESSIONS

I have loved Iron & Wine since his first album, and twenty years later he is still just as good (I know this is an old video, but just listen to him!)

youtu.be/z5iqugyjKas?...

US plan for $1.6m hepatitis B vaccine study in Africa called ‘highly unethical’ Experts decry ‘neocolonialist’ Guinea-Bissau study after Trump administration changed advice for US babies

At a minimum, every researcher directly or indirectly related to this trial should be barred from any research position, project, consortium or funding whatsoever in the EU @erc.europa.eu @ec.europa.eu

www.theguardian.com/society/2025...

A green lifetime biosensor for calcium that remains bright over its full dynamic range Directed evolution was used to engineer a green fluorescent biosensor for quantitative calcium imaging that remains fluorescent, yet shows a large change in lifetime in cells.

The 'Version of Record' of our paper came out on #FluorescenceFriday
elifesciences.org/articles/105...

The field of peptide therapeutics is exploding with many new approvals in the last decade. However, the manufacturing of peptide therapeutics is lagging behind. We have been investing in novel approaches to manufacture peptides since 2016.

Never forget: Elon Musk has blood on his hands.

adam.tsuris @AdamTsuris Somewhere along the way, being wrong about facts was reclassified as "having an opinion," and knowing facts was stigmatized as "having bias." It's a big part of why we're in hell now.

The pKas of both acids are quite different (2.2 main chain, 4.3 side chain), so activating the side chain carboxylic acid might be easier? 🤷🏻‍♂️

I will never forget and never forgive these actions. And there are so many, with so many people carrying these orders out while others laugh and clap and post excited selfies about it all.

Justice has to be served.

Quantifying reviewer declines in scientific publishing: twenty-one years of data from biological invasions 2002–2024 - Biological Invasions The peer review process has been fundamental to scientific publishing since the mid-twentieth century because it helps to ensure scientific rigor and integrity. However, as fewer scientists seem willi...

Quantifying reviewer declines in scientific publishing: twenty-one years of data from biological invasions 2002–2024

link.springer.com/article/10.1...

Learning to say “no” is essential for surviving academia. I’m still trying, though…

You can buy the original pigment and the matte synthetic resin binder developed for YK so the blue color maintain as much of its intensity as possible. You can get something pretty close to the original Kleins

www.adam-eshop.com/en/538-mediu...

Black-and-white album cover showing cellist Sonia Wieder-Atherton standing behind her cello with one hand on the fingerboard and the other holding the bow. The title “Bach Cello Suites Nos. 1 & 2” appears in white text at the top right, along with her name. The Alpha Classics logo sits in the bottom right corner.

Just got Sonia Wieder-Atherton’s Bach Cello Suites Nos. 1 and 2, and now my whole set of her Bach's recordings is complete. Very few recordings can compete with this beauty.