Gina DeNicola

Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social

Hot science and hot temperatures at the FASEB Ferroptosis conference start tonight. Seriously the highs are 110F here 🥵 but it's beautiful!

To distract from your own stress responses (!!!), check out this awesome new study from the Commisso lab linking metabolic stress to regulation of the pancreatic tumor microenvironment! ✨

It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃

IMPORTANT IMPORTANT IMPORTANT IMPORTANT

Please watch the workshop video and COMMENT by 5:00 Monday 7/14

This is the source of the "no more model organism only grants in NIH-funded research" decree.

New work from @karrethlab.bsky.social!

FRA1 drives melanoma metastasis through an actionable transcriptional network https://www.biorxiv.org/content/10.1101/2025.06.07.658418v1

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress respon...

Unravelling cysteine-deficiency-associated rapid weight loss

www.nature.com/articles/s41...

Great work by @rushika-perera.bsky.social!

gumball and anais from the amazing world of gumball are sitting at a table ALT: gumball and anais from the amazing world of gumball are sitting at a table

REMINDER.....REMINDER......REMINDER

3 DAYS LEFT TO COMMENT ON SCHEDULE F

1/n

Samantha Lewis

Our latest ‘Cell Scientist to Watch’ is Samantha Lewis. We caught up with Samantha to discuss her career path, the challenges for working on the ‘neglected’ mitochondrial genome and the exciting new frontiers in mitochondrial research.
journals.biologists.com/jcs/article/...
#JCSMitoSI

So excited for this!

Spatial mapping of the brain metabolome lipidome and glycome - Nature Communications Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed reg...

MALDI imaging of lipids, metabolites and glycans all on the same section! From Ramon Sun and colleagues. www.nature.com/articles/s41...

Figure showing that mitochondrial subpopulations proximal to endosomes and lipid droplets have similar proteomes, but both are significantly different from an average mitochondrial proteome.

In their Tools & Resources article, Corey Cunningham @cnfxc.bsky.social Jared Rutter @rutterlab.bsky.social @uofubiochem.bsky.social & team present their dual-purification system to isolate mitochondrial subpopulations.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #Mitochondria

I am so very proud of Amanda for what she has accomplished in this study, of manuscript she wrote, and of her fearlessness in science. She is a superstar 🌟 I would also like to give a shoutout to our newest lab member Basma Yasseen who carried the revisions over the finish line 💪

Now came the real surprise! Tumors could form lacking both GSR and TXNRD1. Cytosolic disulfide reductase activity is necessary for the reduction of protein disulfides, cystine, and other molecules so how this is possible is still a mystery - and the focus on ongoing work!

Amanda found GSR deletion impaired tumor initiation, regardless of NRF2 status, while TXNRD1 deletion impaired progression to the adenoma stage specifically in NRF2 mutant tumors. This suggested they had non-overlapping roles at these stages.

NRF2 regulates both glutathione and thioredoxin recycling via glutathione reductase (GSR) and thioredoxin reductase 1 (TXNRD1), which have unique and overlapping disulfide targets. Amanda wondered whether these enzymes would be redundant or would they both be required for tumorigenesis?

Distinct roles for the thioredoxin and glutathione antioxidant systems in Nrf2-Mediated lung tumor initiation and progression Redox regulators are emerging as critical mediators of lung tumorigenesis. NRF2 and its negative regulator KEAP1 are commonly mutated in human lung ca…

🚨New paper alert! Led by former undergrad Amanda Sherwood @tophinogenesis.bsky.social (now PhD student at Northwestern), Amanda asked whether the glutathione or thioredoxin systems are necessary for NRF2's tumor-promoting effects in the lung. www.sciencedirect.com/science/arti...

...Michele Hartsough, Nicole Lopanik, Thekla Cordes, Gloria Asantewaa, Christina Adams, Tim Wang, Feroza Choudhury, Brad Mills, and Brad Smith! See you next year!

also thanks to all the workshop panelists, including @lyssiotislab.bsky.social @airdlab.bsky.social @colofflab.com @naama-kanarek.bsky.social @marasherman.bsky.social @louisefets.bsky.social @jcmunger.bsky.social @faubert.bsky.social @kristabledsoe.bsky.social ...

thanks to co-organizers @rushika-perera.bsky.social @muirlab.bsky.social @lydiafinley.bsky.social Dan Tennant, Dirk Brenner and Kristin Brown.

That's a wrap on the 2025 Cancer Metabolism Showcase. With everything going on it was so great to hear a fantastic career keynote from Jeff Rathmell and awesome talks and posters from students and postdocs! Hats off to @harrislab.bsky.social for running the show.

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

The Department of Human Genetics at the University of Utah is sponsoring the Rising Stars in Genetics and Genomics symposium!

- We are seeking nominations bu June 1.
- September 18-19, 2025
- Please share with the star postdocs that you know.

docs.google.com/forms/d/e/1F...

#FOLSCR is a new conference exploring all aspects of a form of cell death that results from iron accumulation and lipid peroxidation. Hear keynotes @ginadenicola.bsky.social and @brentstockwell.bsky.social with organizers Scott Dixon and @olzmannlab.bsky.social. Save your space: buff.ly/MmJsYQq

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids Wang et al. advance bacteria-based metabolic therapy by developing DL@SFEc+ through dual-selection evolution. The evolved SFEc+ significantly enhances CySS uptake and desulfhydrase activity. Combined ...

Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids: Cell Metabolism www.cell.com/cell-metabol...

Discovery of a gut-joint axis pathway and the salutary role of GLP-1 for "wear and tear" arthritis.
New @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...