The BrainPOP research team (left to right): Professor Kate Drummond, Dr Jim Whittle, Dr Saskia Freytag, Dr Sarah Best
Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas.
🔗 www.wehi.edu.au/news/world-f...
22.08.2025 22:31 — 👍 12 🔁 6 💬 1 📌 0
@sarahannbest.bsky.social @saskiafreytag.bsky.social afreytag.bsky.social @jimwhittle.bsky.social whittle.bsky.social @natmed.nature.com edicine.bsky.social @wehi-research.bsky.social @petermaccc.bsky.social
22.08.2025 21:51 — 👍 0 🔁 0 💬 0 📌 0
We would like to thank our amazing team, especially Kate Drummond, clinical and research collaborators and the patients in this trial. We are excited to expand our expertise and dive more deeply into what is driving response.
8/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
Yes! Our collaborators @Florey performed patch clamp electrophysiology on fresh tissue pre- and post-treatment and found a reduction in synaptic activity.
This is consistent with recently published results in a clinical trial of another mIDH inhibitor, where patients reported fewer seizures!
7/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
Spatially, neurons in the leading edge of tumours seemed to have a decrease in synaptic signalling pathway expression.
Could the mIDH inhibitor, or the resulting reduction in the metabolite 2-HG, be impacting neuronal activity?
6/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
A central question in neuro-oncology is whether therapies penetrate the tumour and exert a biological effect.
@jimwhittle.bsky.social and colleagues developed BrainPOP, a perioperative clinical trial platform and our lab had the pleasure of leading the translational research.
1/8
22.08.2025 21:51 — 👍 0 🔁 0 💬 1 📌 0
Next: what happens transcriptionally when mIDH is inhibited? @montanaspiteri.bsky.social investigated the impacts on a single-cell level and found that the progenitor population became less differentiated following treatment.
5/8
22.08.2025 21:41 — 👍 0 🔁 0 💬 0 📌 0
Our first answer: the drug gets in! We can see from the spatial distribution of metabolite biomarker 2-HG that mIDH treatment markedly reduces 2-HG abundance throughout the tumour using spatial metabolomics with @sai22vinod.bsky.social and colleagues.
4/8
22.08.2025 21:41 — 👍 0 🔁 0 💬 1 📌 0
Clinical trial design
IDH-mutant glioma patients underwent a pre-treatment biopsy followed by one cycle of treatment and surgical resection of tumour.
We coordinated multi-omic analyses to interrogate drug activity in LGG, focusing on transcriptomic and metabolomic impacts of the drug, using the paired samples.
3/8
22.08.2025 21:41 — 👍 0 🔁 0 💬 1 📌 0
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