Mike Lange

Fantastic! Congratulations Gunes!!!

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis Ferroptosis, a regulated form of cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic target in cancer. Ferroptosis suppressor protein 1 (FSP1) is a critical regul...

Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis.
www.biorxiv.org/content/10.1...

The count down has begun! 1-week until the 1st FASEB Ferroptosis conference! Looking forward to seeing everyone at the meeting. Get excited!! 🤩
events.faseb.org/event/11797f...

My third paper from grad school is out on Biorxiv! This was a fun collaboration with @olzmannlab.bsky.social where we show that Ferroptosis Suppressor Protein-1 is a better target than GPX4 because it disrupts Treg function while leaving effector T cell function intact.

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity A burgeoning approach to treat cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting anti-ferroptotic pathways in the broader tumor microe...

New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩
www.biorxiv.org/content/10.1...

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...

Yes!

The world is small... Randomly found out that @mikelangelipid.bsky.social and I are both in Osaka, so we met up for some drinks and #lipidtime talk.

It was fun hanging out! Come again!

It's out! Amazing! Congratulations!!!!

this is such a fantastic paper! Congrats to all these exciting findings!

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Here is the exciting original publication: www.nature.com/articles/s41...

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Rapid Response Bridge Funding Program In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

**Rapid Response Bridge Funding Program** -- $25,000 grants earmarked for early-career researchers whose NSF-funded research on STEM and education has just been terminated.

www.spencer.org/grant_types/...

hub.jhu.edu/2025/04/28/j...

Thanks @lizneeley.bsky.social !

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Join us next week: Bits and Bites on May 8, from 9-1pm, on Zoom. Registration and payment here: na.eventscloud.com/ereg/index.p... We will present and discuss the best practice for #Quality Control and Quality Assurance. #metabolomics #NMR #GC-MS #LC-MS @mikelangelipid.bsky.social @crick.ac.uk

Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform

A Lancet Editorial: “American chaos: standing up for health and medicine”

“...to care is an act not of weakness, but of strength.”

The Lancet response: bit.ly/4jRb5Av

RIP any human subjects methods section: women, gender, female, excluded

RIP math/stats: biases, marginalise, equality, inequality, group, inclusive

RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural

This is not just evil it is also SO VERY DUMB

list of banned keywords

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.

I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!

Pls repost 🙏❤️

Amazing review! Congrats to all authors!!

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

Thank you André!

Thank you Bianca!

Thank you Alex!

I am excited to report the preprint of my postdoc work in the @olzmannlab.bsky.social! We have discovered the first lipid droplet quality control pathway with broad implications for lipid physiology and diseases associated with LD accumulation and oxidative stress! #lipidtime

shorturl.at/2HqFd

That's awesome! Congratulations Mike!