Elias Adriaenssens

Atomic models of the Toxoplasma cell invasion machinery Nature Structural & Molecular Biology, Published online: 09 December 2025; doi:10.1038/s41594-025-01728-wZeng et al. applied single-particle cryo-electron microscopy to native samples isolated from the human parasite Toxoplasma gondii, determining multiple structures of key components of the conoid, a cone-shaped organelle essential for host cell invasion.

New online: Atomic models of the Toxoplasma cell invasion machinery

Don't miss out on attending the Mar 15-20th 2026 GRC on #Autophagy in Ventura, California! All the latest findings from the field - check out the program and come tell us about your amazing science.
www.grc.org/autophagy-in...

Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB

We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics

With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...

Congratulations @elliottlab.bsky.social ! Fantastic to see this beautiful work out!

📣 Last mito911 webinar of 2025! Join us for @micharapelab.bsky.social on Dec 11th 8am PST.
Register here: us06web.zoom.us/webinar/regi...

Skin deep: Unconventional autophagy eats away TNF-driven skin inflammation Tumor necrosis factor (TNF), type I interferons (IFNs), and autophagy are important biological processes, but their interactions in inflammation have not been explored. In this issue of Immunity, Prie...

ATG9A-mediated autophagy curbs skin inflammation by suppressing STING activation and ZBP1-dependent cell death @cp-immunity.bsky.social
preview www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

See you all Thursday at MITOchats!! @mitotalks.bsky.social @mito-news.bsky.social @mitowomen.bsky.social @mitoworld.bsky.social

✨New preprint!

🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬

🔗👇

A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses Increased activity of leucine-rich repeat kinase 2 (LRRK2) is an important risk factor for Parkinson’s disease. LRRK2 localizes to lysosomal membranes, and changes in lysosome physiology are emerging ...

New research led by Devin Clegg that defines how lysosome swelling and lysosome deacidification evoke distinct routes for LRRK2 activation: doi.org/10.1101/2025...

SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.

A cellular cross-species RNA-seq atlas captures the transcriptional dynamics of myogenesis Skeletal muscle formation and regeneration is a tightly regulated process involving extensive transcriptional reprogramming as proliferating myoblasts fuse into mature myotubes. However, a comparative...

🚨 New #MyoBlue preprint: Today, we report a cellular cross-species RNA-seq atlas of myogenesis - using mouse & human cell culture models combined with in vivo snRNA-seq from muscle we provide a comprehensive resource for investigating #SkeletalMuscle differentiation.

www.biorxiv.org/content/10.6...

Here, we critically review the structures of the mitochondrial pyruvate carrier (MPC) in apo and ligand-bound states, highlighting controversies with regard to the orientation in the inner membrane, interpretation of the transport states, and modelling of the inhibitors.
doi.org/10.1016/j.ti...

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p6...

Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Michael Rape, PhD, from the University of California.

👇 Reserve your spot using the link below.

📅 December 11
⏰ 11:00 AM EST
RSVP: bit.ly/44jzLeP

@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/...

📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

Structure and mechanism of the mitochondrial calcium transporter NCLX - Nature Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for the...

Structure and mechanism of the mitochondrial calcium transporter NCLX.

YouTube video by Schmidt Ocean Collaboration for Understanding | Searching for the Asgards

And ‘Searching for the Asgards’ the movie: www.youtube.com/watch?v=mgmE...

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵

Systematic discovery of TIR-based immune signaling systems in bacteria Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...

I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life.

www.biorxiv.org/content/10.6...

In ISSUE 23
Highligh: IL-26 - no guts, no glory
Review: initiating autophagy by selective receptors
Method: 3D-SPARK for spatial mapping of DNA synthesis
Resource: senotypes across aging human and mouse tissues
Cover: Sachin Kotak et al @spindlebehavior.bsky.social
link.springer.com/journal/4431...

Pharmacological activation of AMPK rescues mitophagy defects in models of FBXL4-related mitochondrial DNA depletion syndrome https://www.biorxiv.org/content/10.64898/2025.12.03.692069v1

Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation Nature Structural & Molecular Biology, Published online: 03 December 2025; doi:10.1038/s41594-025-01726-yMitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy, the authors show that TAs bind to the 5′ untranslated region of their target transcript to position mitoribosomes for initiation.

New online: Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation

Freaking wild videos - go watch all of them! I cannot decide which one I love more! Radler et al. "Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)" Very creative live-microscopy work #testthymetagenomichypotheses
www.biorxiv.org/content/10.1...

ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity @natgenet.nature.com @stanforduniversity.bsky.social
www.nature.com/articles/s41...

Last MitoTALK of 2025!

Ewa Warczak
@bomba_ewa

From Synthesis to Stability: Understanding the Lifecycle of Mitochondrial Proteins

Thursday, December 4, usual time.

See you there?
mitotalks.org

VAPB is a critical regulating factor in cGAS-STING–mediated innate immune responses
www.science.org/doi/10.1126/...

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.