Timothy Watkins

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Great article by @nobelprize.bsky.social laureate @ardemp.bskyverified.social outlining the health, economic and national security benefits of US biomedical research, and the devastation of government efforts to destroy our leading edge.

www.cnn.com/2025/04/09/h...

Firing 10,000 health experts doesn’t make America healthier—it makes us sicker. This purge guts disease response, disrupts life-saving research, and leaves us vulnerable to outbreaks.

Who benefits from weaker public health? Not the American people.

Watkins, @ellenfoxman.bsky.social et al. reveal that high burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. https://buff.ly/4jRFC18

📘 Host–Microbe Interactions 👉 https://buff.ly/40XMv8r

Salvage treatment of multi-refractory primary immune thrombocytopenia with CD19 CAR T cells Primary immune thrombocytopenia is an autoimmune disease in which autoreactive B cells play a crucial role in pathogenesis by producing autoantibodies primarily directed against platelet surface glycoproteins (eg, glycoprotein IIb/IIIa; fibrinogen receptor) that trigger platelet destruction, resulting in severe thrombocytopenia. The annualised incidence of primary immune thrombocytopenia is approximately 3·3 cases per 100 000 people among adults.1 Despite several treatment options, including approved thrombopoietin receptor agonists and commonly used antibody-reducing approaches—such as B-cell depletion with the anti-CD20 monoclonal antibody rituximab, BTK inhibitors, SYK inhibitors, corticosteroids, and splenectomy—a subset of patients develop refractory immune thrombocytopenia.

'The success of CD19 CAR T-cell therapy is based on the deep B-cell depletion they can induce. Tissue-resident B cells in lymphoid organs can be completely eliminated by CAR T cells, but not by monoclonal antibodies'
#Immunology #Immunotherapy #Immunosky

www.thelancet.com/journals/lan...

The measles vaccine is given as a shot but it is surprisingly good at inducing protective immunity in the respiratory tract (mucosal IgA). Our new study provides some clues about why...a thread (1/8) #IDSky #MedSky #lungs #immunology #ImmunoSky academic.oup.com/jid/advance-...

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