João Paulo Capela

The EU is relying on Science based facts!
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Uso de paracetamol durante a gravidez mantém-se inalterado na UE Infarmed

As autoridades de saúde Portuguesas e Europeias estão a funcionar bem. Triste caso este da FDA nos EUA associar paracetamol com autismo, descredibilizando a ciência. Na EU e em Portugal acreditamos na Ciência!
www.infarmed.pt/web/infarmed...
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Discover Toxicology Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and ...

Discover Toxicology, journal published by Springer Nature invites you to submit full-length or review articles on the “Toxicity of New Psychoactive Substances (NPS)”. Full fee waiver if your article is submitted by the end of October 2025.
Please DM me for questions.
link.springer.com/journal/44339

Discover Toxicology Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and ...

Aligning with this year's World Environment Day theme “End Plastic Pollution," Discover Toxicology has launched a topical Collection: Toxicological Impacts of Microplastics in Freshwater Ecosystems. Submission Deadline: 31 Oct 2025!

Nature’s global survey of PhD students

Have you taken part in Nature’s global survey of PhD students? We’ve had thousands of responses so far and would love to hear from you too. It should take no more than 15 mins and you can opt into a prize draw at the end. Survey closes 11 June. http://spklr.io/63320hAcC
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The European Drug Report 2025 is out.
Cannabis remains by far the most commonly consumed illicit drug in EU, which is followed by Cocaine.
Synthetic cathinones, which I study, are increasingly integrated into EU drug market.
www.euda.europa.eu/publications...

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World Environment Day 2025 Celebrating World Environment Day by showcasing our Discover Toxicology content on environmental toxicology and calling for papers

To support World Environment Day, the journal Discover Toxicology has selected four articles related to environmental toxicology that discuss human impact on the environment. See them at:
communities.springernature.com/posts/world-...
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I don’t think AI can help in reviewing, and more importantly manny journals do not allow it for some very good reasons. I rejected a paper recently because it was found that it was clearly AI written! However, using AI to fine tune English should be fine.

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EU medicines agency quits X, moves to Bluesky The European Medicines Agency (EMA) said on Monday it would no longer post on X and would use rival Bluesky instead, becoming the latest organisation to quit a social media platform that some have criticised for its content.

More one among manny in the EU!

www.reuters.com/world/europe...

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I'm writing about amphetamine therapeutic use on obesity. I mean d-amphetamine or the racemic mixture, not other amphetamine-like drug. Can anyone tell if amphetamine is still approved in any country for obesity or weight loss? Thanks!
#Amphetamine
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Clinical trials back then agreed in a minor, but statistically significant effect. The problems are the adverse events like cardiovascular and potential abuse.

I'm writing about amphetamine therapeutic use on obesity. I mean d-amphetamine or the racemic mixture, not other amphetamine-like drug. Can anyone tell if amphetamine is still approved in any country for obesity or weight loss? Thanks!
#Amphetamine
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#ToxSky
#MedSky
#NeuroSky
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Our latest on Melatonin in food supplements and Medicines in Portugal. Up to 2mg is considered a food supplement, above a medicine! Food supplements contain melatonin and plant extracts and should be more carefully studied.
www.scielo.br/j/bjps/a/5t5...

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More one good news for science 🧪

Vera Marisa Costa no LinkedIn: É com grande orgulho que recebi, no dia 18 de dezembro de 2024, o Prémio… É com grande orgulho que recebi, no dia 18 de dezembro de 2024, o Prémio Nunes Correa Verdades de Faria, atribuído pela Santa Casa da Misericórdia de Lisboa…

Congratulations Vera for receiving this prestigious scientific career recognition prize!

Muitos parabéns Vera por este merecido prémio de reconhecimento da tua carreira científica!

🤗🤗🤗🎉🎉🎉

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pt.linkedin.com/posts/vera-m...

Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

Good day for Science! Drugs should be used following solid proof of efficacy without serious adverse events.

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www.science.org/content/arti...

Trippy Science Unravels the Mystery of Psychedelics’ Antianxiety Effects Researchers mimic the antianxiety effects of psychedelics by identifying and activating specific brain regions in an important step towards developing therapeutics that do not cause hallucinations.

For those interested in the anxiolytic effect of psychedelics I leave an interesting read. It seems interesting the possibility to dissociate the antianxiety effect of psychedelics from their hallucinogenic ones.

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www.the-scientist.com/trippy-scien...

MDMA pharmacokinetics: A population and physiologically based pharmacokinetics model‐informed analysis Midomafetamine (3,4-methylenedioxymethamphetamine [MDMA]) is under the U.S. Food and Drug Administration review for treatment of post-traumatic stress disorder in adults. MDMA is metabolized by CYP2D...

Found this recent study on MDMA #ecstasy pharmacokinetics in humans. For those interested in the therapeutic prospects in PSTD, MDMA is a potent CYP2D6 inhibitor it can have relevant drug–drug interactions.
ascpt.onlinelibrary.wiley.com/doi/full/10....

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That brings me back good memories, when I stayed until late hours I the lab✌️🧠🧪

Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview - Molecular Neurobiology “Ecstasy” [(±)-3,4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse. Several reports raised the concern that ...

Here is a paper, already with some years, that reviews the potential neurotoxicity of MDMA.

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link.springer.com/article/10.1...

MDMA could be helpful in PSTD or other brain disorders. There should be clinical trials not only showing effectiveness but also safety, not only in the short but also in the long term. Caution is required due to the potential neurotoxicity and hepatotoxic actions of MDMA and it’s metabolites. 🧪

Concordo plenamente com a hipocrisia social. A nível universitário, por exemplo, há muita publicidade e patrocínios de bebidas alcoólicas, que a meu ver deviam ser repensados a favor da saúde pública.

Mais uma investigadora de renome a dizer o óbvio! O financiamento da FCT no próxima OE vai baixar e seguramente no ano seguinte será igual. Se já estávamos com um nível baixo de financiamento da FCT, vamos ficar ainda pior!

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

“For scientists the network is starting to look like home.”
Strongly agree. I never had so many scientist interacting with my posts like I do now in Bluesky.

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www.science.org/content/arti...

Great. Add me, thanks.

Thanks for your interest. Bit amphetamine and methylphenidate are used in ADHD. So in controlled doses and settings they can be therapeutically useful. The major problem with these two drugs are cardiovascular, and trials reveal no major adverse effects that could undermine its use.

I understand your concerns regarding the cardiovascular adverse effects, which no doubt should be given attention. The clinical trails did not show that adverse effects under control doses and settings were a problem. They did reveal mixed results, some improved others detailed no improvement.

Thanks for your interest in our work. In fact regarding the brain it makes sense the use of stimulants for this neurological disorders. In particular methylphenidate, that is used to treat ADHD, has been given more attention for stroke or TBI.

Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review The prevalence of stroke and traumatic brain injury is increasing worldwide. However, current treatments do not fully cure or stop their progression, acting mostly on symptoms. Amphetamine and methylp...

For those in the field, look at our latest review article on:
"Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review"

www.degruyter.com/document/doi...

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