Nott Lab

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Alt text: Man smiling on blue background with the quote: "We are developing a treatment that is less grueling for patients and giving hope to those who have been told that there are no further treatment options."

King’s spinout Nuclide Therapeutics is pioneering a new radioactive treatment targeting cancers that resist chemo and radiotherapy.

A £5m investment will now fund its first clinical trial in lung cancer patients.

www.kcl.ac.uk/news/kings-s...

#WorldCancerDay

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates, Alexander I.M. Sever, Rashik Ahmed, Philip Rößler, Lewis E. Kay* @lek-lab.bsky.social @utoronto.ca www.sciencedirect.com/science/arti... #NMRchat 🧲

Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...

Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work,

New paper out! Why do condensates prefer some surfaces and not others? Check it out here: doi.org/10.1063/5.02...

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles Cells chemically isolate molecules in compartments to both facilitate and regulate their interactions. In addition to membrane-encapsulated compartmen…

10 years! 🎉 Time flies. Reflecting on a decade since this was published: www.sciencedirect.com/science/arti...

Postdoctoral Research Associate in Disordered Protein Interactions

We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch!

3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...

Burton Lecture 2025 Please join us in-person and online for the annual Burton Lecture at King's College London with Professor Charlotte Williams OBE FRS.

Join us for the #BurtonLecture25! 🌟⁠

We are thrilled to welcome Prof Charlotte Williams OBE FRS, @ox.ac.uk, who will explore how polymers can be redesigned to reduce greenhouse gas emissions.

📅 3 Apr, Thu
⏰ 17.00 - 20.00
📍SE1 1UL

Register ⬇️

Puddle in a pothole reflects the Shard building

Self-healing #potholes could pave the way for sustainable roads.

Joint research by kingsnmes.bksy.social, swanseauni.bsky.social and Google Cloud is tackling the UK’s £143 million pothole problem.

👉 www.kcl.ac.uk/news/self-healing-potholes-pave-the-way-for-more-sustainable-roads
#ScienceAtKings

Molecular determinants of condensate composition Biomolecular condensates are non-stochiometric assemblies that organize cellular matter in space and time. Despite much work, many questions remain regarding what determines the recruitment and exclus...

New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions

www.cell.com/molecular-ce...

Wheatstone Lecture 2025: Professor Hagan Bayley

Join us for the Wheatstone Lecture 2025 !🌟

Prof Hagan Bayley, @ox.ac.uk, will delve into the fascinating world of nanopores – tiny protein structures revolutionising DNA sequencing and tissue engineering.

📅 26 Feb 2025
⏰17:00 - 19:30
📍Strand Campus

Register ⬇️
www.eventbrite.co.uk/e/wheatstone...

BBC Radio 4 - In Our Time, The Habitability of Planets Melvyn Bragg and guests discuss ideas about where life may begin in the universe and how.

What #chemistry is needed for life to begin? And what signs of life should we be looking for in the #universe to learn if we are alone? 🪐

Dr Saidul Islam, from @kingsnmes.bsky.social discusses the habitability of planets with @bbcradio4.bsky.social #InOurTime. 👇

www.bbc.co.uk/programmes/m...

Now That's What I Call Disordered

A look at just how disordered a disordered protein-protein pair can get. Do they even care about stereochemistry any more?