Bioengineer Clifford Brangwynne wins Keio Medical Science Prize Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.

these people in my lab are amazing

Awesome work Anita, congrats on an amazing paper!

Starting as an undergraduate project, an experiment reveals cells’ secrets Holly Cheng and her colleagues were the first to successfully use micropipette aspiration to measure parts from a living cell while they were still biologically active

Check out this awesome story about the work of an awesome (former) undergrad in our lab @hollycheng.bsky.social who worked closely w @zs-biophys.bsky.social‬ Howard Stone, James Roggeveen & Huan Wang. bioengineering.princeton.edu/news/2025/st...

Congrats @yoonjikim.bsky.social and co-authors!!!!!

It has been a dream come true to lead a rotation in the @mblscience.bsky.social Physiology course - thanks to the amazing Directors @gladfelterlab.bsky.social and @brangwynnelab.bsky.social, course staff, TAs, and students!

Mapping and engineering RNA-driven architecture of the multiphase nucleolus - Nature Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.

Combining sequencing and imaging, @brangwynnelab.bsky.social maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. 🧪 🧬

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

An amazing group of students this year in Brangwynne rotation @mblscience.bsky.social Physiology course!!!!

How to spy on condensates - Nature Methods Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks.

How to spy on condensates: technology feature in
@natmethods.nature.com
Our views on the topic, by Hyman,Rosen,Brangwynne, Sabari, Kappel,Xu & myself, presented here
@hymanlab.bsky.social @brangwynnelab.bsky.social @bsabari.bsky.social @kallikappel.bsky.social
www.nature.com/articles/s41...

How to spy on condensates - Nature Methods Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks.

How to spy on condensates: technology feature in @natmethods.nature.com on self-organization and collective properties of condensates with quotes from Anthony Hyman @hymanlab.bsky.social @mpi-cbg.de, @brangwynnelab.bsky.social, and many more. www.nature.com/articles/s41...

How to spy on condensates - Nature Methods Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks.

Nice article about the latest in the biomolecular condensate field, with some nice images and quotes from us. www.nature.com/articles/s41...

The one and only Manu @prakashlab.bsky.social
inspiring @mblscience.bsky.social Physiology students at this morning's lecture.

A great morning with the @mblscience.bsky.social
Physiology students after my talk today.

Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liquids do not need to be spherical!), from amazing duo @dnamystrom.bsky.social & Hongbo Zhao, w/ important contributions from co-authors Jorine Eeftens, Mikko Haataja, Andrej Kosmrlj.

Princeton's new Omenn-Darling Bioengineering Institute is hiring! New building opening this Fall, & Princeton is an awesome place to live & do amazing research at intersection of engineering & life sciences. **Please spread the word*** bioengineering.princeton.edu/join/open.

Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...

Such a wonderful symposium at UMichigan! And a fantastic opportunity to connect with our beloved benefactors (and Michiganders) Gil Omenn and Martha Darling, together with my Princeton/Omenn-Darling Bioengineering Institute colleague (& Deputy Director) @toettch.bsky.social

Very glad to contribute to this cool study of of nucleoli, led by former Princeton undergrad Holly Cheng!

P.S., we all looked much younger when we were working on this project (see picture below) 😁

Congrats to this year's Brangwynne lab new PhD Kevin Xu (co-advised with Avalos) and graduating undergrads Aya Abu-Alfa and Emmett Grover. Kevin is now CEO of a startup, Aya is off to MD/PhD program, and Emmett to medical school. Congratulations - we are so proud of you!!!!

Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social‬ &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122

Photos of Clifford Brangwynne, James Nuñez and Leoardo Morsut with the titles of the talks they will give at the 2025 Saltiel Life Sciences Symposium: "Tools for probing the assembly and function of ribosomes," "Editing the epigenomes of human cells with CRISPR," and "Synthetic signaling applications to control patterning and morphogenesis in developmental systems"

The 2025 Saltiel Life Sciences Symposium is this Thursday (5/29)!
@brangwynnelab.bsky.social will start us off with the Mary Sue and Kenneth Coleman Lecture at 9:00 AM, followed by talks from @jamesknunez.bsky.social at 9:55 and @leonardomorsut.bsky.social at 10:25.
myumi.ch/lsi-symposiu...

So grateful for our amazing inaugural advisory council for the Omenn-Darling Bioengineering Institute, who came to Princeton last week to learn about and help guide all that is happening in ODBI, the future of Bioengineering at Princeton. Thank you all!!! bioengineering.princeton.edu

Genome-wide mapping of mesoscale neuronal RNA organization and condensation Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

Lovely dinner tonight with Nathan Vardi, author of the page-turner "For Blood and Money: Billionaires, Biotech, and the Quest for a Blockbuster Drug". Nathan will speak to Princeton students in our Biotech class tomorrow, can't wait!

Cool work from some amazing Princeton colleagues!

Princeton's Omenn-Darling Bioengineering Institute is looking for a Cell Engineering facility Director. A tremendous opportunity to join our growing community, in brand-new building & brand new Institute! Please spread the word!!! bioengineering.princeton.edu. puwebp.princeton.edu/AcadHire/app...

Corelet™ Platform: Precision High Throughput Screening for Targeted Drug Discovery of Biomolecular Condensates Biomolecular condensates (BMCs) are crucial for cellular organization and function, and their dysregulation is linked to neurological, oncologic and i…

Excited about Nereid's progress in using our Corelet technology to find new drugs: Corelet™ Platform: Precision High Throughput Screening for Targeted Dr... sciencedirect.com/science/arti...

It's All about the Talent | Molecular Biology of the Cell

“… without scientific progress no amount of achievement in other directions can insure our health, prosperity, and security as a nation in the modern world." - written half a century ago, by Vannevar Bush, more relevant today than ever. see this piece by Princeton's Tilghman: doi.org/10.1091/mbc....