Abigail Mackey

Top Cited Review Article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber

Super exciting 🤩

A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...

Our tendon enthusiasts @ccstorytime.bsky.social & @annesofieagergaard.bsky.social are in Nanjing, China for an international meeting focused on orthopedic surgery and sports medicine talking about their approach with circadian rhythms and exercise-based treatment on tackling tendinopathy ⏰🏋️‍♀️ #tendon

Safe travels and have a great trip!

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training-induced changes in muscle morphology, function and gene networks relative to placebo ingestion...

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28...

@jphysiol.bsky.social

Lovely #FluorescenceFriday

Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

From the team, Bjørk Wulff West Helge & Kenneth Mertz presented data from our studies on ultrarunners & bodybuilders show the impact of extreme training volume and severe energy restriction 🏃‍♀️💪 (2/2)

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

Looking for a PhD ? Don’t miss ⬇️
12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica !
www.euraxess.fr/jobs/375945
@themeshwork.bsky.social @matrixbiologie.bsky.social
#ECM #collagen #WoundHealing
#proteases

Can green proteins match animal protein in supporting muscle health after menopause?

Congratulations to @grithhojfeldt.bsky.social on receiving nearly DKK 4 million from the @novo-nordisk.bsky.social to investigate sustainable proteins, strength training & healthy aging in women. 👏🌱🥛🧬

This morning we have a presentation from Kenneth Mertz about relative energy deficiency in sports, the myths around the topic, the sparse literature and how they aim to investigate REDS in athletes 💪🥗🏋️‍♀️ Check out his most recent work on effect on bone 🦴
onlinelibrary.wiley.com/doi/10.1155/...

Great postdoc opportunity here👇

Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

Time to bring out the big 🔫 for this morning meeting! Prof. Michael Krogsgaard gives an insightful presentation on the problem of the ankle and highlights the unanswered scientific questions of how to best treat them through surgical means💡

We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue.

The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles:

www.biorxiv.org/content/10.1...

🧵

"thought-provoking evidence that resident adult stem cells can rejuvenate aged tissue to a more youthful state" - fascinating!

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations | Physiology | American Physiological Society From shrews to whales, mammals exhibit a range of heart rates that varies more than 100-fold. Whilst the fundamental processes of cardiac contraction are conserved, the repertoire of contractile prote...

The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations
journals.physiology.org/doi/abs/10.1...

Today’s department meeting was presented by Max Ravn Merkel on the research MAGNETOM Free.Star MRI scanner and its possibilities. We also had an introduction to what the new CPH Center for Translational Research has to offer 🤩 Lots of new tools for our researchers with enthusiastic support 👩‍🔬

Well deserved, Ask 👏

Congrats to our two winners of the @dsmb-dk.bsky.social annual meeting best oral presentation prizes! Best heparan sulfate talk sponsored by Amsbio goes to Jessica Oyie Sousa Onyeisi @gotteprof.bsky.social lab&best ECM talk sponsored by Tebubio goes to Ask Møbjerg @ismcopenhagen.bsky.social
#proudPI

At the @dsmb-dk.bsky.social Annual Meeting 2025 and PhD student Ask Møbjerg is presenting our latest work on the acute effects of exercise on ECM remodelling of human muscle-tendon tissues using snRNAseq and RNAscope 🏋️‍♀️🔬

@ismcopenhagen.bsky.social

Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training Abstract figure legend Human skeletal muscle proteome response was investigated after 10-week resistance training (RT1) followed by 10-week training cessation (i.e. detraining, DT), and finally, 10-w...

physoc.onlinelibrary.wiley.com/doi/10.1113/...

What is next for the ‘muscle memory’ conundrum? Unresolved questions and future research directions Click on the article title to read more.

The authors discuss our recent article (link in comments) and its implications. Many questions remain to be elucidated. Muscle memory research is still in its early stages.

physoc.onlinelibrary.wiley.com/doi/10.1113/...
@jphysiol.bsky.social

The state of mechanistic research in the evidence‐based medicine era: A sandwalk between triangulation and hierarchies Click on the article title to read more.

An interesting read:
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Excited to start on this study with our collaborators at University Southern Denmark and learn about bones!

Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise

@myoblue.bsky.social

Team Tendon bids farewell to @steffendanielle.bsky.social and celebrates a paper submission tonight with a lovely meal out together 🥰 We’ll miss her energy, insightful questions and friendly presence at @ismcopenhagen.bsky.social