Barak Rotblat @barakrotblat

the paper after revisions

04.08.2025 15:18 — 👍 1 🔁 0 💬 1 📌 0

זה כמו שמעתיקים קובץ בווינדוס ולאחוז האחרון לוקח הכי הרבה זמן. לסגור מאמר זו מלחמת חפירות

04.08.2025 08:41 — 👍 3 🔁 0 💬 0 📌 0

inspiration 👇

03.08.2025 15:28 — 👍 1 🔁 0 💬 0 📌 0

sounds like good fun

03.08.2025 15:27 — 👍 1 🔁 0 💬 1 📌 0

true👇

03.08.2025 11:55 — 👍 3 🔁 0 💬 0 📌 0

nice one🧗

03.08.2025 11:54 — 👍 1 🔁 0 💬 2 📌 0

less incentives to publish crap on rxiv vs journals

01.08.2025 16:57 — 👍 1 🔁 0 💬 0 📌 0

interesting!🙏

01.08.2025 16:54 — 👍 0 🔁 0 💬 0 📌 0

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...

To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...

01.08.2025 09:06 — 👍 37 🔁 7 💬 2 📌 0

interesting 🙏

01.08.2025 16:45 — 👍 0 🔁 0 💬 0 📌 0

valid points. the q is will it be better or worse vs the average human reviewer. will it be more biased, less fair and through ext. perhaps a hybrid system?

01.08.2025 05:21 — 👍 1 🔁 0 💬 1 📌 0

👀

31.07.2025 15:25 — 👍 0 🔁 0 💬 0 📌 0

rtfm🕺

31.07.2025 15:24 — 👍 5 🔁 1 💬 0 📌 0

ai review?

31.07.2025 15:20 — 👍 2 🔁 0 💬 1 📌 0

it was fantastic!
great piece @josiegz.bsky.social
#TCTeAC

31.07.2025 03:35 — 👍 2 🔁 1 💬 1 📌 0

check it out👇

29.07.2025 15:23 — 👍 0 🔁 0 💬 0 📌 0

amazing!

29.07.2025 15:23 — 👍 0 🔁 0 💬 0 📌 0

will this be retracted?

28.07.2025 08:28 — 👍 0 🔁 0 💬 0 📌 0

משתתף בצערך איתי

21.07.2025 13:02 — 👍 2 🔁 0 💬 1 📌 0

JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols Jove

Our Journal of Visualised Experiments methods collection "Methods to assess mitochondrial biogenesis and bioenergetics" is still accepting submissions. Take a look at what is already available. Thank you to all the contributors so far #mitochondria #jove

app.jove.com/methods-coll...

21.07.2025 07:25 — 👍 1 🔁 1 💬 0 📌 0

I like a good cover

18.07.2025 14:02 — 👍 0 🔁 0 💬 0 📌 0

how I picture Editor handling my paper

18.07.2025 13:44 — 👍 2 🔁 0 💬 0 📌 0

time for ai reviews

16.07.2025 04:24 — 👍 2 🔁 1 💬 1 📌 0

cihr cv, hold my beer

11.07.2025 15:52 — 👍 3 🔁 0 💬 0 📌 0

A stress-dependent postembryonic role for the core CPA factor CFIM-1 in germline integrity Post-transcriptional processing of pre-mRNAs generates a diversity of 3’ UTR transcript isoforms that can vary in their function and stability. The differential enrichment of transcript isoforms has been implicated in diseases ranging from cancer to neurodevelopmental disorders. However, the post-embryonic developmental roles of the core ensemble of cleavage and polyadenylation (CPA) factors that mediate these post-transcriptional changes remain poorly characterized. Here, we report a stress- dependent role for the core CPA factor CFIM-1 in germline integrity in Caenorhabditis elegans. Total loss-of-function of cfim-1 elicits a temperature-sensitive sterile phenotype in hermaphrodites. These changes in brood size are accompanied by broad sperm, oocyte and germline morphology defects. Surveying the transcriptome of cfim-1(lf) worms, we uncover changes in transcript isoform abundance for dozens of genes with known functions related to the development and maintenance of these structures, consistent with a model in which post-transcriptional regulation of target genes via cfim- 1 is crucial to the development and maintenance of germline integrity. Our findings collectively define a novel post-embryonic role for a core CPA factor in tissue-specific development. ### Competing Interest Statement The authors have declared no competing interest. Canadian Institutes of Health Research, PJT 155928

If you are interested in alternative polyadenylation (APA) check out our latest pre-print on the role of the APA factor CFIM-1 (NUDT21) in the C. elegans germline. www.biorxiv.org/content/10.1...

07.07.2025 20:38 — 👍 14 🔁 6 💬 1 📌 0

Congrats Bent and co!👏

08.07.2025 11:35 — 👍 1 🔁 0 💬 1 📌 0

how cool is this? "G4-RNA forms an electron conduit enabling cathodic EET in this MHC-deficient archaeon"👇

08.07.2025 09:22 — 👍 1 🔁 0 💬 0 📌 0

spotted on the ride to work

08.07.2025 09:17 — 👍 5 🔁 0 💬 0 📌 0

אני לא יודע ויש הרבה מחקרים אבל ממה שאני כן מכיר לא מדובר במחלות שיש חשש להתפרצות מגיפה. יש מחקר על סרטן וזה לדוגמא לא יכול להתפשט. הכל מאוד מבוקר ומתועד אז אני מניח שאם היה חשש היינו יודעים מזה. אם זאת, בהחלט נפגעו מחקרים חשובים והושחט זמן יקר

02.07.2025 16:30 — 👍 7 🔁 0 💬 1 📌 0

epic indeed :)

25.06.2025 10:09 — 👍 6 🔁 1 💬 0 📌 0

Barak Rotblat

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