Robin Larsson

Breastfeeding boosts immune cells that protect against breast cancer The protective, long-lived T cells can persist for decades after a woman gives birth.

Pregnancy and breastfeeding induces the accumulation of specialized immune cells that reduce the chances of breast cancer developing

go.nature.com/3Jln0Jy

Equally surprise the authors also failed to discuss this confounder, considering that physical activity/exercise is generally recommended as first line treatment for OA (and since the data is apparently available in the Osteoarthritis Initiative).

(PDF) Limited effects of non-steroidal anti-inflammatory drugs (NSAIDs) on imaging outcomes in osteoarthritis: observational data from the osteoarthritis initiative (OAI) PDF | Background Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for pain relief in osteoarthritis (OA), and their... | Find, read and cite all the research you need on Research...

"NSAID use had a modest association with reduced structural cartilage damage progression." A rather spectacular find, until you realise they didn't control for physical activity, and participants on NSAIDs were likely more active due to the analgesic effect.

pmc.ncbi.nlm.nih.gov/articles/PMC...

(Although I've since stoped using the term subacromial impingement as it's unprecise and misleading.)

Effects of eccentric exercise in patients with subacromial impingement syndrome: a systematic review and meta-analysis - BMC Musculoskeletal Disorders Background Subacromial impingement syndrome is a common problem in primary healthcare. It often include tendinopathy. While exercise therapy is effective for this condition, it is not clear which type...

Six years ago almost to the day since our paper on eccentric exercise and subacromial impingement got published. 23 000+ reads, 47+ citations, included in 2 clinical guidelines.

bmcmusculoskeletdisord.biomedcentral.com/articles/10....

Risk factors for long-term sickness absence in patients with high-impact chronic pain – a scoping review and Swedish register-based cohort study High-impact chronic pain (HICP) affects 8% of individuals worldwide. Beyond its direct consequences, HICP increases the risk of long-term sickness absence (LTSA), leading to income loss and increased ...

Advance Access in The Journal of Pain to our newly accepted cohort study of 10,552 patients investigating risk factors for long-term sickness absence in patients with high-impact chronic pain: www.jpain.org/article/S152...

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Adherence to a healthy plant-based diet, including vegetables, fruits, whole grains, nuts, and legumes, may be beneficial for breast cancer prevention, mainly in postmenopausal women, finds a study published in the Journal of Health, Population and Nutrition.
bit.ly/3YBXrsj

#MedSky #OncoSky

Do Swedish rock-climbers exhibit more eating disorder and body dissatisfaction symptoms than non-climbers? A cross-sectional study - PubMed NCT05587270.

New-ish study finds higher levels of body dissatisfaction in non-climbers, especially in men, where symptoms were three times higher than rock-climbers. pubmed.ncbi.nlm.nih.gov/39414282/

TL;DR: Low to moderate evidence suggests that taping might reduce bowstringing of the finger flexor tendons. Moderate evidence suggests that taping has no effect on MVC or muscle activation in uninjured climbers. For other outcomes more studies evaluating the effects of taping are needed.

To tape or not to tape: annular ligament (pulley) injuries in rock climbers—a systematic review - BMC Sports Science, Medicine and Rehabilitation Background Popularity of rock climbing is steadily increasing. With its inclusion in the Olympic Games this will likely continue. Injuries from rock climbing are also increasing. The most common injury is to the flexor pulley system, consisting of the finger flexors and five annular ligaments (pulleys). Treatment of this injury includes taping of affected fingers, but evaluation of this treatment was previously lacking. The aim of this review was therefore to assess whether taping is associated with better outcomes than non-taping. A secondary aim was to present treatment recommendations or areas for future research. Methods Systematic searches of PubMed, Scopus, SPORTDiscus, Cochrane Library, PEDro and CINAHL. Free text searches of Google Scholar. Citation searching. No restrictions to language, date of publication or study design. Included studies were assessed using Cochrane scale for clinical relevance, by two independent authors. Results were presented in narrative synthesis. Certainty of evidence (GRADE) was assessed by three authors. Review was done according to PICO-protocol and reported according to PRISMA-guidelines. Results After removing duplicates, 595 records were identified. Eight studies and one case report (in nine articles, one poster) were included, consisting of 206 rock climbers, four non-climbers, 23 pairs of cadaver hands. Clinical relevance ranged from 0 to 5 (median 2). Evidence of low to moderate certainty suggests that taping might reduce bowstringing of the finger flexor tendons by 15–22%. Evidence regarding pain, time for return to sports, shearing forces against pulleys, pulley ruptures and maximum voluntary contraction (MVC) were all regarded as “very low”, “very low to low” or “low”, and were not considered reliable. Evidence of moderate certainty suggests that taping has no effect on MVC or muscle activation in uninjured rock climbers. No adverse effects of taping were reported. Conclusion Low to moderate evidence suggests that taping might reduce bowstringing of the finger flexor tendons. Moderate evidence suggests that taping has no effect on MVC or muscle activation in uninjured climbers. For other outcomes more studies evaluating the effects of taping are needed. Trial registration: PROSPERO CRD42021241271, date of registration: 18-04-2021.

ICYMI: Here is our systematic review on taping of pulley injuries in rock climbers (open access)!

bmcsportsscimedrehabil.biomedcentral.com/articles/10....

Rookie scientists make research teams more innovative Papers from research teams with a substantial number of beginners are highly disruptive and innovative, study shows.

Papers from research teams with a substantial number of beginners are highly disruptive and innovative

go.nature.com/4nrEvqg

Then again, when climbing interventions were compared to waitlist or individual interventions, it proved superior - and when it was compared to other group interventions, there were no between group differences - clearly highlighting the importance of group interactions and feelings of belonging.

Hard to say, in general, being part of open supportive community clearly has therapeutic merit -we discuss this confunder of group cohesiveness in discussions-section- but in included trials, the climbing intervention was delivered by medical personnel & exposure to climbing community might be less.

Dietary creatine intake and mental health among the Korean population Several population-based studies suggest that dietary creatine may benefit depression and cognitive function, but no research has examined overall mental health in a non-U.S. population or included...

Higher dietary creatine intake may have modest protective effects against depression, suicidality, and anxiety.

www.tandfonline.com/doi/full/10....

TL;DR: Indoor rock climbing, particularly bouldering (combined with mindfulness exercises), appears to be an effective, clinically meaningful, safe, and sustainable adjunctive intervention for adults with moderate depression.

Effectiveness of indoor rock climbing and bouldering as treatment for depression – a systematic review - BMC Psychiatry Introduction Depression is one of the most prevalent disorders worldwide. In addition to psychotherapy, cognitive behavioural therapy and antidepressants, exercise therapy is frequently recommended, with emerging evidence highlighting the unique characteristics of rock climbing, including its potential to promote mindfulness, making it a promising therapy. This review aimed to assess whether rock climbing reduces symptoms of depression, the magnitude of effect, and whether effects are sustained long-term. Methods Systematic review conducted according to PICO framework and reported according to PRISMA-statement. Eligible studies were controlled trials assessing indoor rock climbing versus any comparator, including adults with moderate depression, with symptoms reduction on validated depression scales as outcome. Systematic searches were conducted in PubMed, Scopus, and Web of Science (inception to January 2025), with no language or publication date restrictions. Screening (via Rayyan), data extraction, and methodological quality assessment (using PEDro scale) were performed independently and in duplicate. Clinical relevance was assessed using minimal clinically important difference (MCID). Due to heterogeneity of interventions and comparators, findings were narratively synthesized. Certainty of evidence was rated using GRADE. Results Out of 1,832 identified records, seven studies (reported in 10 articles) including 471 participants, met PICO-criteria. Included studies were conducted between 2015 and 2023, in Germany/Austria. Methodological quality was generally good (median PEDro score 6/10). Indoor bouldering (combined with mindfulness exercises) significantly reduced symptoms of depression from moderate to mild (e.g. -8.3 points on MADRS, exceeding MCID of 5 points), indicating a clinically meaningful improvement compared to no intervention (high certainty evidence). Longer duration interventions (8–10 weeks) were needed for effects to persist at 6–12 months (high certainty evidence). Four weeks of top-rope climbing also reduced symptoms of depression from moderate to mild, were sustained long-term, but did not exceed MCID (low certainty evidence). No adverse events were reported. Conclusions Indoor rock climbing, particularly bouldering (combined with mindfulness exercises), appears to be an effective, clinically meaningful, safe, and sustainable adjunctive intervention for adults with moderate depression. However, further high-quality trials are needed to isolate the effects of rock climbing from co-interventions and to compare it with established treatments such as antidepressants and aerobic exercise. Trial registration PROSPERO: CRD42024468119, date of registration: 24-01-2024.

Our #systematicreview on the effectiveness of indoor rock climbing and bouldering as treatment for depression just published in BMC Psychiatry (@bmc.springernature.com)

bmcpsychiatry.biomedcentral.com/articles/10....

World's first AI-designed viruses a step towards AI-generated life Nature - Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

Scientists have created the first ever viruses designed by AI, and they’re capable of hunting down and killing strains of E. coli

go.nature.com/4nA8E6p

Saw in patient journal today that colleague had ordered a shoulder x-ray for a patient, just in case there might be some degenerative changes... the patient was 80+ yo.

Dear Americans, welcome to the thrilling game of ‘Did this dictator die or just disappear for a day?’ We’ve been playing it with Putin and Lukashenko for decades. Enjoy the suspense.

Peer reviewers more likely to approve articles that cite their own work Nature - Preprint examines how citations can influence the review process.

Reviewers are more likely to approve a manuscript if their own work is cited

go.nature.com/4oOf3MI

Figure. SPIRIT 2025 Diagram of the Schedule of Enrollment, Interventions, and Assessments

📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research.

ja.ma/4fzMVZS

I Am Taking a GLP-1 Weight-Loss Medication—What Should I Know? This JAMA Internal Medicine Patient Page describes how glucagon-like peptide-1 (GLP-1) receptor agonists work and what behaviors to adopt while using them.

From @jamainternalmed.com: This JAMA patient page covers #GLP1 weight-loss medications, focusing on food craving reduction, blood glucose control, dietary strategies, exercise for muscle retention, and lifestyle changes to prevent weight regain.


ja.ma/3TQnEQU

YouTube video by Medlife Crisis Doctor Reveals THAT ONE WEIRD TRICK to Make Line Go Up 📈 🤑🫀🚀🚀

This top tier by @medcrisis.bsky.social
Get yours today it can't be beat

youtu.be/IwqZy-r3dIU?...

Eight US states seek to outlaw chemtrails – even though they aren’t real States introduce chemtrail-coded legislation as conspiracy theories take root in some US chambers

Make America Stupid Again

www.theguardian.com/us-news/2025...

The active piriformis test evaluates for piriformis syndrome with a sensitivity of 78%, specificity of 80%!

Watch: www.youtube.com/watch?v=l_Xi...

Read: wikism.org/Active_Pirif...

#sportsmed #sportsmedicine #medicine #sports #foamSM #MedEd #FOAMed #ortho #medtwitter #OrthoTwitter #medschool

First they came for the undocumented workers and we doom-scrolled.
Then they came for members of the trans community and we doom-scrolled.
Then they terminated signal transduction and transgenic grants and ...

"Gender-affirming communication can preserve the sacredness of patient-clinician relationships."

This Viewpoint discusses how clinicians can use affirming language and actions to support transgender patients.

#MedSky #MedEd

ja.ma/44dnKbv

Can a pill replace exercise? Swigging this molecule gives mice benefits of working out The compound betaine, which becomes more abundant in men who take up jogging, could confer some of the anti-ageing advtanages of physical activity.

The compound betaine, which becomes more abundant in men who take up jogging, could confer some of the anti-ageing advtanages of physical activity

https://go.nature.com/3TGRKpS

People are told meat is good for them, but I want to challenge these lies. Meat is violence, raises the risk of chronic diseases, destroys the environment & fuels zoonotic diseases.

Students must see animals as sentient beings, not commodities.

Picture at Columbia University.
#vegan