VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution
Protein-protein interactions underlie core brain functions, including neurotransmitter release, receptor activation, and intracellular signaling essential for learning, memory, and cognition. Here, we systematically map conserved brain protein interactions across five vertebrate species-rabbit, chicken, dolphin, pig, and mouse-using co-fractionation and immunoprecipitation mass spectrometry. From 2,197 biochemical fractions, we identify over 82,000 high-confidence interactions among 6,108 conserved proteins. This interaction map (VerteBrain) reveals both regulatory and structural complexes, including extensive synaptonemal protein associations likely involved in inter-neuronal coordination. Conservation across species underscores essential roles in neuronal and glial function, as well as in additional tissues for more widely expressed complexes. The VerteBrain dataset also uncovers candidate disease mechanisms, including roles for ARHGEF1 in short stature syndromes, synaptic vesicle trafficking complexes in epilepsy, and RELCH in congenital deafness. VerteBrain provides a publicly accessible framework for investigating brain protein interactions and their relevance to human neurological disorders.
(BioRxiv All) VerteBrain reveals novel neural and non-neural protein assemblies conserved across vertebrate evolution: Protein-protein interactions underlie core brain functions, including neurotransmitter release, receptor activation, and intracellular signaling essential for⦠#BioRxiv #MassSpecRSS
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EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...
28.05.2025 15:52 β π 44 π 19 π¬ 0 π 1
Congrats Ben!
27.11.2024 20:35 β π 2 π 0 π¬ 0 π 0
Systems biology | Bioinformatics | Cancer | Genetic interactions
https://cancerdata.ucd.ie/
(he / him)
Old person forgetting everything they ever knew about proteomics at speeds in excess of 270 Hz...
Proteomics software for analyzing high-resolution mass-spectrometry data.
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Free to download: https://www.maxquant.org/maxquant/.
Assistant Professor @ UdeM/CR-CHUM
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Scientist for Humanityπ¨βπ¬
Proteomics , EVs, and Machine Learning π¬
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Professor in Biomolecular Mass Spectrometry and Proteomics, Utrecht University, the Netherlands
Finished just outside the top 3 Most Responsible Person in our 4 person household for a record 13 years.
A multi-disciplinary research cluster studying the machinery of microbial life - from their fine molecular structure to interactions with their hosts and the environment.
https://www.sheffield.ac.uk/biosciences/research/areas/molecular-microbiology
Retired biochemist. Technologically overstimulated ex-scientist. π΄σ §σ ’σ ·σ ¬σ ³σ Ώ Proudly a FLSW, currently VP STEMM π΄σ §σ ’σ ·σ ¬σ ³σ Ώ
Keen π· of mostly π¦. See Bird pics: http://rjbwild.smugmug.com
Inventor of Zwitter!
Web site: http://www.phbuffers.org
Laboratory for Immunochemical Circuits at the La Jolla Institute for Immunology. Dept. of Pharmacology and Moore's Cancer Center, UCSD. Global Autoimmune Institute Assistant Professor. samyerslab.org
PhD student in biochemistry
University of SΓ£o Paulo π§π·
Proteomics| Mass spectrometry| Proteolysis
Chief Product Officer at IonOpticks | Separator of peptides and proteoforms | Proteomics
Virologist, bioinformatician, NGS, photographer.
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Post doc in the Emmott Labπ©π»βπ¬π©π»βπ»
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rebee.co.uk
Born in Glasgow. Live in Edinburgh. Scientist. Celtic Fan, LGBT Ally. All views are my own.
